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Albano, C. et al.

Albano, Platteau, Nogueira, Cortvrindt, Smitz, Devroey,

Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction.

OBJECTIVE: To evaluate the effect of supernumerary preovulatory follicular reduction as an approach to avoid multiple pregnancies in ovulation induction or superovulation cycles. DESIGN: Retrospective study. SETTING: Tertiary referral center. PATIENT(S): In 26 cycles, 24 patients underwent ovulation induction or superovulation with either clomiphene citrate or hMG. INTERVENTION(S): Selective follicle aspiration was performed before hCG administration. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate and numbers of multiple pregnancies. RESULT(S): A mean number of 4.5 follicles with a diameter > or =15 mm and a mean number of 4.5 follicles with a diameter < or =14 mm were observed before hCG administration. A mean number of 2.3 follicles with a diameter > or =15 mm and a mean number of 1.8 follicles with a diameter < or =14 mm were aspirated before the hCG administration. Seven singleton pregnancies (26.9% per cycle) ensued from the treatment. CONCLUSION(S): Aspiration of supernumerary follicles after ovulation induction or superovulation seems to be a valid approach to avoid multiple pregnancies without affecting pregnancy rate.[1]

References

Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction. Albano, C., Platteau, P., Nogueira, D., Cortvrindt, R., Smitz, J., Devroey, P. Fertil. Steril. (2001) [Pubmed]

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