Disease relevance of Subitex

• Degradation of 2-sec-butyl-4,6-dinitrophenol (dinoseb) by Clostridium bifermentans KMR-1 [1].
• Effects in mice of high and low environmental temperature on the maternal and fetal toxicity of 2-sec-butyl-4,6-dinitrophenol (dinoseb) and on disposition of [14C]-dinoseb(12) [2].
• Severe irritant contact dermatitis from Cypress spurge [3].
• Plant dermatitis. Irritant plants in the spurge family (Euphorbiaceae) [4].

High impact information on Subitex

• The Mediterranean spurge Euphorbia dendroides L. afforded a series of 10 closely related jatrophane polyesters, nine of which are new, which served as a base for the establishment of structure-activity relationships within this class of P-glycoprotein inhibitors [5].
• Purification and properties of two lectins from the latex of the euphorbiaceous plants Hura crepitans L. (sand-box tree) and Euphorbia characias L. (Mediterranean spurge) [6].
• (Mediterranean spurge), two lectins were purified by affinity chromatography on acid-treated Sepharose 6B followed by elution with D-galactose [6].
• Subtractive cDNA libraries identify differentially expressed genes in dormant and growing buds of leafy spurge (Euphorbia esula) [7].
• Cloning and characterization of cold-regulated glycine-rich RNA-binding protein genes from leafy spurge (Euphorbia esula L.) and comparison to heterologous genomic clones [8].

Biological context of Subitex

• Two subtractive cDNA libraries were developed to study genes associated with bud dormancy (reverse library) and initiation of shoot growth (forward library) in leafy spurge [7].
• Cuticular hydrocarbons of the flea beetles, Aphthona lacertosa and Aphthona nigriscutis, biocontrol agents for leafy spurge (Euphorbia esula) [9].
• Spurge infestation can reduce cattle carrying capacity by 50 to 75 percent [1] [10].
• This paper reports an HPLC-UV and HPLC-positive-ESI-MS analysis of the diterpenoid fraction of caper spurge seed oil before and after selective hydrolysis of ingenol-based L-factors [11].
• University of Wyoming Entomology doctoral candidate Vonny Barlow is conducting research in the area of biological control of leafy spurge via the Aphthona nigriscutis Foudras flea beetle [10].

Anatomical context of Subitex

• Biochemical mechanisms of cytotoxicity induced by the herbicides paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride), dinoseb (2-sec-butyl-4,6-dinitrophenol) and 2,4-D (2,4-dichlorophenoxyacetic acid) were investigated in freshly isolated rat hepatocytes [12].
• We present results of phylogenetic analyses of mitochondrial, nuclear, and plastid data showing that Rafflesiaceae are derived from within Euphorbiaceae, the spurge family [13].

Associations of Subitex with other chemical compounds

• Total activity was significantly (p less than 0.05) increased over vehicle controls in both grouped and individual subjects by A, F, and D following dermal administration [14].
• Sorption of two dinitrophenolic herbicides, 4,6-dinitro-o-cresol (DNOC) and 4,6-dinitro-2-sec-butylphenol (DINOSEB) to smectite was studied using FTIR, HPLC, and quantum chemical methods [15].
• Changes in metabolism of Japanese medaka (Oryzias latipes) embryos exposed to dinoseb (2-sec-butyl-4,6-dinitrophenol), a substituted dinitrophenol herbicide, were determined by in vivo (31)P NMR, high-pressure liquid chromatography (HPLC)-UV, and (1)H NMR metabolomics [16].

Gene context of Subitex

• Dietary cancer risk from conditional cancerogens (tumor promoters) in produce of livestock fed on species of spurge (Euphorbiaceae). V. Skin irriitant and tumor-promoting diterpene ester toxins of the tigliane and ingenane type in the herbs Euphorbia nubica and Euphorbia helioscopia contaminating fodder of livestock [17].
• Leafy spurge (Euphorbia esula L.), a plant introduced into the Great Plains of North America from Europe, has become a serious economic and ecological threat to the productivity of agricultural and natural areas [18].
• The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris) [19].

Analytical, diagnostic and therapeutic context of Subitex

• A strain of Clostridium bifermentans, KMR-1, degraded 2-sec-butyl-4,6-dinitrophenol (dinoseb) to a level below the limit of detection by high-performance liquid chromatography (0.5 mg/liter) within 96 h, with no accumulation of aromatic intermediates [1].
• Acute kerato-uveitis associated with topical self-administration of the sap of the Petty Spurge (Euphorbia peplus) [20].

References