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Disease relevance of Superovulation


High impact information on Superovulation

  • Aged female Bax-/- mice fail to become pregnant when housed with young adult males; however, metaphase II oocytes can be retrieved from, and corpora lutea form in, ovaries of aged Bax-/- females following superovulation with exogenous gonadotropins, and some oocytes are competent for in vitro fertilization and early embryogenesis [6].
  • Hsf2(-/-) females also display hormone response defects, that can be rescued by superovulation treatment, and exhibit abnormal rates of luteinizing hormone receptor mRNAs [7].
  • Further studies showed that superovulation caused a dramatic increase in the expression of mouse ovastacin, indicating that the production of this enzyme is under hormonal regulation [8].
  • These criteria should help clinicians in managing ovarian responses during IVF superovulation stimulation treatment [9].
  • These results represent the first demonstration that an attenuated LH surge is obtained in normally cycling women during superovulation induction with sequential clomiphene/pulsatile hMG treatment [10].

Chemical compound and disease context of Superovulation


Biological context of Superovulation

  • Timing and superovulation were induced by an injection of pregnant mares' serum on the first morning of the estrus cycle, followed by injection of human chorionic gonadotropin (HCG) in the evening of the fourth day [12].
  • Superovulation of red deer hinds with eCG causes premature luteal regression by inducing follicular hypersecretion of estrogen that activates the luteolytic mechanism [13].
  • The uptake and retention of 3H-estradiol by the ovine corpus luteum (induced by superovulation) was maximal through days 8-12 of the cycle with little or no uptake and retention during luteinization or regression [14].
  • The rapidity and reproducibility of this serum estrogen assay make it suitable for office use in monitoring ovulation induction and superovulation in in vitro fertilization-embryo transfer programs [15].
  • Infertility in these cases, which is due to a functional tubal factor, is best treated with IVF-ET rather than superovulation and intrauterine insemination treatments [16].

Anatomical context of Superovulation


Associations of Superovulation with chemical compounds

  • Alteration of the serum follicle-stimulating hormone to luteinizing hormone ratio in the cyclic hamster treated with antiluteinizing hormone: relationship to serum estradiol, free antiluteinizing hormone, and superovulation [22].
  • Antiluteinizing hormone: chronic influence on steroid and gonadotropin levels and superovulation in the pregnant hamster [23].
  • During the induction of superovulation with PMS and hCG, the values of PdGl increased significantly (P less than 0.0005; by Student's t test) from 2.08 +/- 0.97 to 3.99 +/- 2.55 ng/ml (mean +/- SD) at the time of corpus luteum formation [24].
  • When tested in vivo the ER-sparing antiprogestins were as effective as RU486 in suppressing superovulation [25].
  • In this study, proliferation of the OSE was quantified in response to superovulation induced by ip injection of pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG) in immature 27-d-old CD1 mice using bromodeoxyuridine (BrdU) [26].

Gene context of Superovulation


Analytical, diagnostic and therapeutic context of Superovulation


  1. Effect of superovulation with human menopausal gonadotropins on growth hormone levels in women. Wilson, E.E., Word, R.A., Byrd, W., Carr, B.R. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  2. Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis: a controlled randomized study. Fedele, L., Bianchi, S., Marchini, M., Villa, L., Brioschi, D., Parazzini, F. Fertil. Steril. (1992) [Pubmed]
  3. Ovarian hyperstimulation syndrome after superovulation using GnRH agonists for IVF and related procedures. Rizk, B., Smitz, J. Hum. Reprod. (1992) [Pubmed]
  4. The use of gonadotrophin releasing hormone agonists for in vitro fertilization and other assisted procreation techniques: experience from three centres. Smitz, J., Ron-El, R., Tarlatzis, B.C. Hum. Reprod. (1992) [Pubmed]
  5. Effects of gossypol from cottonseed meal and dietary vitamin E on the reproductive characteristics of superovulated beef heifers. Velasquez-Pereira, J., Aréchiga, C.F., McDowell, L.R., Hansen, P.J., Chenoweth, P.J., Calhoun, M.C., Risco, C.A., Batra, T.R., Williams, S.N., Wilkinson, N.S. J. Anim. Sci. (2002) [Pubmed]
  6. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Perez, G.I., Robles, R., Knudson, C.M., Flaws, J.A., Korsmeyer, S.J., Tilly, J.L. Nat. Genet. (1999) [Pubmed]
  7. Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice. Kallio, M., Chang, Y., Manuel, M., Alastalo, T.P., Rallu, M., Gitton, Y., Pirkkala, L., Loones, M.T., Paslaru, L., Larney, S., Hiard, S., Morange, M., Sistonen, L., Mezger, V. EMBO J. (2002) [Pubmed]
  8. Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. Quesada, V., Sánchez, L.M., Alvarez, J., López-Otín, C. J. Biol. Chem. (2004) [Pubmed]
  9. An analysis of plasma estradiol concentrations during clomiphene citrate-human menopausal gonadotropin stimulation in an in vitro fertilization-embryo transfer program. Okamoto, S., Healy, D.L., Howlett, D.T., Rogers, P.A., Leeton, J.F., Trounson, A.O., Wood, E.C. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  10. Endogenous luteinizing hormone surge during superovulation induction with sequential use of clomiphene citrate and pulsatile human menopausal gonadotropin. Messinis, I.E., Templeton, A., Baird, D.T. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  11. Ovulation stimulation and induction. Blacker, C.M. Endocrinol. Metab. Clin. North Am. (1992) [Pubmed]
  12. Timing of meiotic stages in oocytes of the Syrian hamster (Mesocricetus auratus) and analysis of induced chromosome aberrations. Basler, A. Hum. Genet. (1978) [Pubmed]
  13. Premature luteal regression induced by equine chorionic gonadotropin and estrogen is suppressed by administration of exogenous interferon in red deer (Cervus elaphus). Bainbridge, D.R., Deakin, D., Jabbour, H.N. Biol. Reprod. (1998) [Pubmed]
  14. Modulation of the uptake and retention of estradiol-17beta in the ovine corpus luteum by luteinizing hormone. Sheridan, P.J., Phillips, J.L., Simmons, K.R., Caffrey, J.L., Abel, J.H., Niswender, G.D. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  15. A rapid serum estrogen assay suitable for office use in monitoring follicular maturation. Kaseki, H., Schmidt, G., Friedman, C.I., Kim, M.H. Obstetrics and gynecology. (1987) [Pubmed]
  16. Chronic cough and infertility: a report of two cases. McLean, L., Claman, P. Fertil. Steril. (2000) [Pubmed]
  17. Effects of an antiandrogen, flutamide, on oocyte quality and embryo development in rats superovulated with pregnant mare's serum gonadotropin. Yun, Y.W., Yuen, B.H., Moon, Y.S. Biol. Reprod. (1988) [Pubmed]
  18. Programming in vitro fertilization for a 5- or 3-day week. Dimitry, E.S., Bates, S.A., Oskarsson, T., Margara, R., Winston, R.M. Fertil. Steril. (1991) [Pubmed]
  19. Immunohistochemical localization of prostaglandin H synthase in the embryo and uterus of the mouse from ovulation through implantation. Marshburn, P.B., Shabanowitz, R.B., Clark, M.R. Mol. Reprod. Dev. (1990) [Pubmed]
  20. Serum inhibin B correlates with successful ovulation in infertile women. Luisi, S., Palumbo, M., Calonaci, G., De Leo, V., Razzi, S., Inaudi, P., Cobellis, G., Petraglia, F. J. Assist. Reprod. Genet. (2003) [Pubmed]
  21. Non-fertility in cows: influence of PGF, PMSG followed by PGF, progesterone and light. Zaayer, D., van der Horst, C.J. Cytobios (1984) [Pubmed]
  22. Alteration of the serum follicle-stimulating hormone to luteinizing hormone ratio in the cyclic hamster treated with antiluteinizing hormone: relationship to serum estradiol, free antiluteinizing hormone, and superovulation. Terranova, P.F., Greenwald, G.S. Endocrinology (1981) [Pubmed]
  23. Antiluteinizing hormone: chronic influence on steroid and gonadotropin levels and superovulation in the pregnant hamster. Terranova, P.F., Greenwald, G.S. Endocrinology (1979) [Pubmed]
  24. The measurement of steroid glucuronides in urine from mice to monitor gonadal function. I. Pregnanediol-3 alpha-glucuronide as an index of progestogen output. Tyler, J.P., Edwards, W.R., Collins, W.P. Endocrinology (1978) [Pubmed]
  25. Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. Sathya, G., Jansen, M.S., Nagel, S.C., Cook, C.E., McDonnell, D.P. Endocrinology (2002) [Pubmed]
  26. Gonadotropin-induced superovulation drives ovarian surface epithelia proliferation in CD1 mice. Burdette, J.E., Kurley, S.J., Kilen, S.M., Mayo, K.E., Woodruff, T.K. Endocrinology (2006) [Pubmed]
  27. The role for the uterine insulin-like growth factor I in early embryonic loss after superovulation in the rat. Katagiri, S., Moon, Y.S., Yuen, B.H. Fertil. Steril. (1996) [Pubmed]
  28. Development of infertility at young adult age in a mouse model of human Sandhoff disease. Juneja, S.C. Reprod. Fertil. Dev. (2002) [Pubmed]
  29. Diversification of cyclooxygenase-2-derived prostaglandins in ovulation and implantation. Matsumoto, H., Ma , W., Smalley, W., Trzaskos, J., Breyer, R.M., Dey, S.K. Biol. Reprod. (2001) [Pubmed]
  30. Maternal serum beta-HCG and alpha-fetoprotein concentrations in singleton pregnancies following assisted reproduction. Perheentupa, A., Ruokonen, A., Tuomivaara, L., Ryynänen, M., Martikainen, H. Hum. Reprod. (2002) [Pubmed]
  31. Oestradiol-17beta, progesterone, FSH and LH in prepubertal calves induced to superovulate. Testart, J., Kann, G., Saumande, J., Thibier, M. J. Reprod. Fertil. (1977) [Pubmed]
  32. The effect of progesterone supplementation around the time of oocyte recovery in patients superovulated for in vitro fertilization. Trounson, A., Howlett, D., Rogers, P., Hoppen, H.O. Fertil. Steril. (1986) [Pubmed]
  33. Heterotopic pregnancies after in vitro fertilization and embryo transfer. Rizk, B., Tan, S.L., Morcos, S., Riddle, A., Brinsden, P., Mason, B.A., Edwards, R.G. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  34. Short versus long gonadotropin-releasing hormone analogue suppression protocols for superovulation in patients > or = 40 years old undergoing intracytoplasmic sperm injection. Sbracia, M., Farina, A., Poverini, R., Morgia, F., Schimberni, M., Aragona, C. Fertil. Steril. (2005) [Pubmed]
  35. Superovulation strategy before in vitro fertilization. Hillier, S.G., Afnan, A.M., Margara, R.A., Winston, R.M. Clinics in obstetrics and gynaecology. (1985) [Pubmed]
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