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Tarazona, R. et al.

NK-associated receptors on CD8 T cells from treatment-naive HIV-infected individuals: defective expression of CD56.

OBJECTIVES: This study addresses the detailed expression of natural killer (NK)- associated receptors on CD8 T lymphocytes in treatment-naive HIV-infected individuals. DESIGN: Experimental study analysing the expression of NK-associated receptors on peripheral blood T lymphocytes from HIV-infected individuals compared with healthy controls. METHODS: Flow cytometry was used to analyse the expression of CD56, CD16, CD94, NKG2A, NKB1, CD161, CD244, and perforin, according to the CD28 phenotype, on CD8(bright) T cells obtained from treatment-naive HIV-infected individuals and from healthy controls. RESULTS: The results showed that CD8(bright) T cells from treatment-naive HIV-infected individuals had a decreased expression of CD56 and that CD8(bright)CD56 cell numbers correlated with CD4 cell counts. NK-associated markers were preferentially expressed on CD8(bright)CD28 negative T cells, both in healthy controls and HIV-infected individuals. An increased expression of CD94, CD244, and perforin, which was the consequence of the expansion of the CD8(bright)CD28 negative T-cell subset, was also observed in HIV infection. CONCLUSIONS: As the CD8(bright)CD56 T cells are the mature cytolytic effector cells, the defective expression of CD56 on CD8(bright) T cells shown in HIV-infected individuals could be involved in the decreased peripheral blood T-cell cytotoxicity found in HIV infection.[1]

References

NK-associated receptors on CD8 T cells from treatment-naive HIV-infected individuals: defective expression of CD56. Tarazona, R., DelaRosa, O., Casado, J.G., Torre-Cisneros, J., Villanueva, J.L., Galiani, M.D., Peña, J., Solana, R. AIDS (2002) [Pubmed]

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