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Gene Review

NCAM1  -  neural cell adhesion molecule 1

Homo sapiens

Synonyms: CD56, MSK39, N-CAM-1, NCAM, NCAM-1, ...
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Disease relevance of NCAM1


Psychiatry related information on NCAM1


High impact information on NCAM1


Chemical compound and disease context of NCAM1

  • Neuroprotection mediated by subtoxic dose of NMDA in SH-SY5Y neuroblastoma cultures: activity-dependent regulation of PSA-NCAM expression [14].
  • By combining intranuclear bromodeoxyuridine (BrdU) staining and analysis of CD56 marker intensity, statistically higher percentages of BrdU(+) cells were found among the CD56(bright) subset than the CD56(dim) subset after 6 days of stimulation with BCG [15].
  • Up to now, no systematic analysis of the expression pattern of CD56 in formalin fixed paraffin embedded bone marrow biopsies of acute leukemias has been performed [16].
  • We immunohistochemically studied the expression of CD56 in a series of 141 bone marrow biopsies fixed in Sublimat Mercury II Chloride (SUSA) including 100 cases of AML FAB M0-M7, 11 cases of AML not further specified, 3 cases of biphenotypical leukemia, 20 cases of acute lymphoblastic leukemia (ALL) and 7 cases of reactive bone marrow biopsies [16].
  • Similar CD56+ luminal cell clusters were also observed in cases of chronic pancreatitis, whereas they were scarce in normal adult and diabetic tissues [17].

Biological context of NCAM1


Anatomical context of NCAM1


Associations of NCAM1 with chemical compounds


Physical interactions of NCAM1

  • Furthermore, ST8Sia IV was able to add polysialic acid to oligosialylated oligosaccharides and unpolysialylated antennas in N-glycans attached to NCAM, even when polysialic acid was attached to at least one of the other antennas [27].
  • GFRalpha1 lacking its N-terminal domain was still able to potentiate GDNF binding to NCAM and assemble into a tripartite receptor complex but showed a reduced capacity to attenuate NCAM-mediated cell adhesion [28].

Enzymatic interactions of NCAM1

  • The MAP kinase activation was sustained, because ERK1 and ERK2 were phosphorylated in PC12-E2 cells and primary hippocampal neurons even after 24 hr of cultivation on NCAM-expressing fibroblasts [29].
  • We examined normal and Huntington's disease (HD) human striatum with specific monoclonal antibodies to nonphosphorylated (SMI 32) and phosphorylated (SMI 31) neurofilament and neural cell adhesion molecule (NCAM) [30].

Regulatory relationships of NCAM1


Other interactions of NCAM1


Analytical, diagnostic and therapeutic context of NCAM1

  • Both fractions thus obtained were subjected to immunoblotting using an anti-N-CAM monoclonal antibody [19].
  • These findings suggest that ligation of FGFR1 by CD56 may contribute to the interaction between NK cells and T cells that we have postulated in our previous studies [21].
  • This was done using a coculture system consisting of PC12-E2 cells grown on fibroblasts, with or without NCAM expression, allowing NCAM-NCAM interactions resulting in neurite outgrowth [29].
  • NCAM was measured in the sera of 70 control subjects and 43 DAT patients (with different severity of cognitive impairment, GDS), employing Western blot and densitometric quantification [7].
  • Immunoprecipitation of a panel of SCLC cell lines by monoclonal antibodies (mAbs) specific for N-CAM detects mainly the 145-kDa isoform [36].


  1. Identification and characterization of TPARM gene in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
  2. Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer. Tanaka, F., Otake, Y., Nakagawa, T., Kawano, Y., Miyahara, R., Li, M., Yanagihara, K., Nakayama, J., Fujimoto, I., Ikenaka, K., Wada, H. Cancer Res. (2000) [Pubmed]
  3. Retinoic acid-induced changes in polysialyltransferase mRNA expression and NCAM polysialylation in human neuroblastoma cells. Seidenfaden, R., Hildebrandt, H. J. Neurobiol. (2001) [Pubmed]
  4. CD56: a useful marker for diagnosing Merkel cell carcinoma. Kurokawa, M., Nabeshima, K., Akiyama, Y., Maeda, S., Nishida, T., Nakayama, F., Amano, M., Ogata, K., Setoyama, M. J. Dermatol. Sci. (2003) [Pubmed]
  5. Correlations among neural cell adhesion molecule, nerve growth factor, and its receptors, TrkA, TrkB, TrkC, and p75, in perineural invasion by basal cell and cutaneous squamous cell carcinomas. Chen-Tsai, C.P., Colome-Grimmer, M., Wagner, R.F. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2004) [Pubmed]
  6. Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals. Arai, M., Itokawa, M., Yamada, K., Toyota, T., Arai, M., Haga, S., Ujike, H., Sora, I., Ikeda, K., Yoshikawa, T. Biol. Psychiatry (2004) [Pubmed]
  7. Neural cell adhesion molecule in human serum. Increased levels in dementia of the Alzheimer type. Todaro, L., Puricelli, L., Gioseffi, H., Guadalupe Pallotta, M., Lastiri, J., Bal de Kier Joffé, E., Varela, M., Sacerdote de Lustig, E. Neurobiol. Dis. (2004) [Pubmed]
  8. Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X-linked hydrocephalus. Rosenthal, A., Jouet, M., Kenwrick, S. Nat. Genet. (1992) [Pubmed]
  9. Reduced reactivity to novelty, impaired social behavior, and enhanced basal synaptic excitatory activity in perforant path projections to the dentate gyrus in young adult mice deficient in the neural cell adhesion molecule CHL1. Morellini, F., Lepsveridze, E., Kähler, B., Dityatev, A., Schachner, M. Mol. Cell. Neurosci. (2007) [Pubmed]
  10. Cell-adhesion molecules, glucocorticoids and long-term-memory formation. Rose, S.P. Trends Neurosci. (1995) [Pubmed]
  11. The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion. Freigang, J., Proba, K., Leder, L., Diederichs, K., Sonderegger, P., Welte, W. Cell (2000) [Pubmed]
  12. X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Jouet, M., Rosenthal, A., Armstrong, G., MacFarlane, J., Stevenson, R., Paterson, J., Metzenberg, A., Ionasescu, V., Temple, K., Kenwrick, S. Nat. Genet. (1994) [Pubmed]
  13. Alternative splicing generates a secreted form of N-CAM in muscle and brain. Gower, H.J., Barton, C.H., Elsom, V.L., Thompson, J., Moore, S.E., Dickson, G., Walsh, F.S. Cell (1988) [Pubmed]
  14. Neuroprotection mediated by subtoxic dose of NMDA in SH-SY5Y neuroblastoma cultures: activity-dependent regulation of PSA-NCAM expression. Singh, J., Kaur, G. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  15. Human CD56bright and CD56dim natural killer cell subsets respond differentially to direct stimulation with Mycobacterium bovis bacillus Calmette-Guérin. Batoni, G., Esin, S., Favilli, F., Pardini, M., Bottai, D., Maisetta, G., Florio, W., Campa, M. Scand. J. Immunol. (2005) [Pubmed]
  16. The expression pattern of CD56 (N-CAM) in human bone marrow biopsies infiltrated by acute leukemia. Khanlari, B., Buser, A., Lugli, A., Tichelli, A., Dirnhofer, S. Leuk. Lymphoma (2003) [Pubmed]
  17. CD56-positive cells with or without synaptophysin expression are recognized in the pancreatic duct epithelium: a study with adult and fetal tissues and specimens from chronic pancreatitis. Fujisawa, M., Notohara, K., Tsukayama, C., Mizuno, R., Okada, S. Acta Med. Okayama (2003) [Pubmed]
  18. Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. Nakayama, J., Fukuda, M.N., Fredette, B., Ranscht, B., Fukuda, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. Evidence for the presence of N-CAM 180 on astrocytes from rat cerebellum and differences in glycan structures between N-CAM 120 and N-CAM 140. Sasaki, T., Endo, T. Glia (1999) [Pubmed]
  20. Gangliogenesis in the enteric nervous system: Roles of the polysialylation of the neural cell adhesion molecule and its regulation by bone morphogenetic protein-4. Faure, C., Chalazonitis, A., Rh??aume, C., Bouchard, G., Sampathkumar, S.G., Yarema, K.J., Gershon, M.D. Dev. Dyn. (2007) [Pubmed]
  21. Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56. Kos, F.J., Chin, C.S. Immunol. Cell Biol. (2002) [Pubmed]
  22. Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX. Angata, K., Suzuki, M., Fukuda, M. J. Biol. Chem. (1998) [Pubmed]
  23. A Novel {alpha}-Helix in the First Fibronectin Type III Repeat of the Neural Cell Adhesion Molecule Is Critical for N-Glycan Polysialylation. Mendiratta, S.S., Sekulic, N., Hernandez-Guzman, F.G., Close, B.E., Lavie, A., Colley, K.J. J. Biol. Chem. (2006) [Pubmed]
  24. Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase. Requirement of core alpha1,6-linked fucose and a polypeptide chain for polysialylation. Kojima, N., Tachida, Y., Yoshida, Y., Tsuji, S. J. Biol. Chem. (1996) [Pubmed]
  25. Molecular dissection of the ST8Sia IV polysialyltransferase. Distinct domains are required for neural cell adhesion molecule recognition and polysialylation. Angata, K., Chan, D., Thibault, J., Fukuda, M. J. Biol. Chem. (2004) [Pubmed]
  26. Identification of sequences in the polysialyltransferases ST8Sia II and ST8Sia IV that are required for the protein-specific polysialylation of the neural cell adhesion molecule, NCAM. Foley, D.A., Swartzentruber, K.G., Colley, K.J. J. Biol. Chem. (2009) [Pubmed]
  27. ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes. Angata, K., Suzuki, M., Fukuda, M. J. Biol. Chem. (2002) [Pubmed]
  28. Insights into GFRalpha1 regulation of neural cell adhesion molecule (NCAM) function from structure-function analysis of the NCAM/GFRalpha1 receptor complex. Sjöstrand, D., Ibáñez, C.F. J. Biol. Chem. (2008) [Pubmed]
  29. Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. Kolkova, K., Novitskaya, V., Pedersen, N., Berezin, V., Bock, E. J. Neurosci. (2000) [Pubmed]
  30. Neurofilament and neural cell adhesion molecule immunocytochemistry of Huntington's disease striatum. Nihei, K., Kowall, N.W. Ann. Neurol. (1992) [Pubmed]
  31. A neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention. Secher, T., Novitskaia, V., Berezin, V., Bock, E., Glenthøj, B., Klementiev, B. Neuroscience (2006) [Pubmed]
  32. Clinical and biological significance of CD56 antigen expression in acute promyelocytic leukemia. Ito, S., Ishida, Y., Oyake, T., Satoh, M., Aoki, Y., Kowata, S., Uchiyama, T., Enomoto, S., Sugawara, T., Numaoka, H., Suzuki, K., Murai, K. Leuk. Lymphoma (2004) [Pubmed]
  33. Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. Ong, E., Yeh, J.C., Ding, Y., Hindsgaul, O., Fukuda, M. J. Biol. Chem. (1998) [Pubmed]
  34. Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells. Kim, B.W., Son, H. Exp. Mol. Med. (2006) [Pubmed]
  35. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. Angata, K., Suzuki, M., McAuliffe, J., Ding, Y., Hindsgaul, O., Fukuda, M. J. Biol. Chem. (2000) [Pubmed]
  36. Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line. Saito, S., Tanio, Y., Tachibana, I., Hayashi, S., Kishimoto, T., Kawase, I. Lung Cancer (1994) [Pubmed]
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