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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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GATA proteins are potential negative regulators of HDC gene expression in the gastric epithelium.

In this study, we used the gastric epithelial cell line AGS-G(R) to investigate the role of GATA transcription factors in the regulation of both basal and gastrin- stimulated L-histidine decarboxylase ( HDC) gene transcription. Using reporter gene technology, we compared the transcriptional activity of a construct, hHDC503, which contained the 5'-flanking region of the human HDC gene with that of similar constructs lacking selected GATA consensus sequences. We demonstrated the expression of GATA-4 and GATA-6 proteins within the AGS-G(R) cells and found evidence that these transcription factors can negatively regulate HDC gene expression.[1]

References

  1. GATA proteins are potential negative regulators of HDC gene expression in the gastric epithelium. Watson, F., Kiernan, R.S., Dimaline, R. Biochim. Biophys. Acta (2002) [Pubmed]
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