Gene Review:
GATA4 - GATA binding protein 4
Homo sapiens
Synonyms:
ASD2, GATA-binding factor 4, TACHD, TOF, Transcription factor GATA-4, ...
Srivastava,
Butler,
Eapen,
Garg,
Benson,
Kasahara,
Hirayama-Yamada,
Joo,
Rothrock,
King,
Schluterman,
Cohen,
Kathiriya,
Matsuoka,
Barnes,
- Histone modifications silence the GATA transcription factor genes in ovarian cancer. Caslini, C., Capo-chichi, C.D., Roland, I.H., Nicolas, E., Yeung, A.T., Xu, X.X. Oncogene (2006)
- Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Bai, Y., Akiyama, Y., Nagasaki, H., Yagi, O.K., Kikuchi, Y., Saito, N., Takeshita, K., Iwai, T., Yuasa, Y. Mol. Carcinog. (2000)
- GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. Pehlivan, T., Pober, B.R., Brueckner, M., Garrett, S., Slaugh, R., Van Rheeden, R., Wilson, D.B., Watson, M.S., Hing, A.V. Am. J. Med. Genet. (1999)
- GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Garg, V., Kathiriya, I.S., Barnes, R., Schluterman, M.K., King, I.N., Butler, C.A., Rothrock, C.R., Eapen, R.S., Hirayama-Yamada, K., Joo, K., Matsuoka, R., Cohen, J.C., Srivastava, D. Nature (2003)
- GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Hellebrekers, D.M., Lentjes, M.H., van den Bosch, S.M., Melotte, V., Wouters, K.A., Daenen, K.L., Smits, K.M., Akiyama, Y., Yuasa, Y., Sanduleanu, S., Khalid-de Bakker, C.A., Jonkers, D., Weijenberg, M.P., Louwagie, J., van Criekinge, W., Carvalho, B., Meijer, G.A., Baylin, S.B., Herman, J.G., de Bruïne, A.P., van Engeland, M. Clin. Cancer Res. (2009)
- A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Molkentin, J.D., Lu, J.R., Antos, C.L., Markham, B., Richardson, J., Robbins, J., Grant, S.R., Olson, E.N. Cell (1998)
- Differentiation of embryonic stem cells is induced by GATA factors. Fujikura, J., Yamato, E., Yonemura, S., Hosoda, K., Masui, S., Nakao, K., Miyazaki Ji, J., Niwa, H. Genes Dev. (2002)
- Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Crispino, J.D., Lodish, M.B., Thurberg, B.L., Litovsky, S.H., Collins, T., Molkentin, J.D., Orkin, S.H. Genes Dev. (2001)
- Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Charron, F., Tsimiklis, G., Arcand, M., Robitaille, L., Liang, Q., Molkentin, J.D., Meloche, S., Nemer, M. Genes Dev. (2001)
- Hypermethylation of the GATA gene family in esophageal cancer. Guo, M., House, M.G., Akiyama, Y., Qi, Y., Capagna, D., Harmon, J., Baylin, S.B., Brock, M.V., Herman, J.G. Int. J. Cancer (2006)
- Protein Kinase C Regulates Internal Initiation of Translation of the GATA-4 mRNA following Vasopressin-induced Hypertrophy of Cardiac Myocytes. Sharma, A., Masri, J., Jo, O.D., Bernath, A., Martin, J., Funk, A., Gera, J. J. Biol. Chem. (2007)
- A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Xin, M., Davis, C.A., Molkentin, J.D., Lien, C.L., Duncan, S.A., Richardson, J.A., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Liang, Q., Wiese, R.J., Bueno, O.F., Dai, Y.S., Markham, B.E., Molkentin, J.D. Mol. Cell. Biol. (2001)
- Myocardin Sumoylation Transactivates Cardiogenic Genes in Pluripotent 10T1/2 Fibroblasts. Wang, J., Li, A., Wang, Z., Feng, X., Olson, E.N., Schwartz, R.J. Mol. Cell. Biol. (2007)
- SUMO-1 modification activated GATA4-dependent cardiogenic gene activity. Wang, J., Feng, X.H., Schwartz, R.J. J. Biol. Chem. (2004)
- Follicle-stimulating hormone-induced activation of gata4 contributes in the up-regulation of cyp19 expression in rat granulosa cells. Kwintkiewicz, J., Cai, Z., Stocco, C. Mol. Endocrinol. (2007)
- Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization). White, R.A., Dowler, L.L., Pasztor, L.M., Gatson, L.L., Adkison, L.R., Angeloni, S.V., Wilson, D.B. Genomics (1995)
- Deletion of a 5-cM region at chromosome 8p23 is associated with a spectrum of congenital heart defects. Giglio, S., Graw, S.L., Gimelli, G., Pirola, B., Varone, P., Voullaire, L., Lerzo, F., Rossi, E., Dellavecchia, C., Bonaglia, M.C., Digilio, M.C., Giannotti, A., Marino, B., Carrozzo, R., Korenberg, J.R., Danesino, C., Sujansky, E., Dallapiccola, B., Zuffardi, O. Circulation (2000)
- The human Cx40 promoter polymorphism -44G-->A differentially affects transcriptional regulation by Sp1 and GATA4. Firouzi, M., Bierhuizen, M.F., Kok, B., Teunissen, B.E., Jansen, A.T., Jongsma, H.J., Groenewegen, W.A. Biochim. Biophys. Acta (2006)
- Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Gao, X., Sedgwick, T., Shi, Y.B., Evans, T. Mol. Cell. Biol. (1998)
- A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function. Su, K., Li, X., Edberg, J.C., Wu, J., Ferguson, P., Kimberly, R.P. J. Immunol. (2004)
- The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. Dai, Y.S., Cserjesi, P., Markham, B.E., Molkentin, J.D. J. Biol. Chem. (2002)
- Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes. Takahashi, T., Lord, B., Schulze, P.C., Fryer, R.M., Sarang, S.S., Gullans, S.R., Lee, R.T. Circulation (2003)
- CCAAT/enhancer-binding protein alpha (C/EBPalpha) activates transcription of the human microsomal epoxide hydrolase gene (EPHX1) through the interaction with DNA-bound NF-Y. Zhu, Q.S., Qian, B., Levy, D. J. Biol. Chem. (2004)
- Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. van Wering, H.M., Bosse, T., Musters, A., de Jong, E., de Jong, N., Hogen Esch, C.E., Boudreau, F., Swain, G.P., Dowling, L.N., Montgomery, R.K., Grand, R.J., Krasinski, S.D. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- Prostaglandin E2 increases cyp19 expression in rat granulosa cells: Implication of GATA-4. Cai, Z., Kwintkiewicz, J., Young, M.E., Stocco, C. Mol. Cell. Endocrinol. (2007)
- GATA-4 binds to an upstream element of the human alpha2(I) collagen gene (COL1A2) and inhibits transcription in fibroblasts. Wang, L., Tanaka, S., Ramirez, F. Matrix Biol. (2005)
- Upregulations of Gata4 and oxytocin receptor are important in cardiomyocyte differentiation processes of P19CL6 cells. Uchida, S., Fuke, S., Tsukahara, T. J. Cell. Biochem. (2007)
- Regulation of human microsomal epoxide hydrolase gene (EPHX1) expression by the transcription factor GATA-4. Zhu, Q.S., Qian, B., Levy, D. Biochim. Biophys. Acta (2004)
- Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. Yamagata, T., Nishida, J., Sakai, R., Tanaka, T., Honda, H., Hirano, N., Mano, H., Yazaki, Y., Hirai, H. Mol. Cell. Biol. (1995)
- Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. Escaffit, F., Boudreau, F., Beaulieu, J.F. J. Cell. Physiol. (2005)
- GATA-4 is a granulosa cell factor employed in inhibin-alpha activation by the TGF-beta pathway. Anttonen, M., Parviainen, H., Kyrönlahti, A., Bielinska, M., Wilson, D.B., Ritvos, O., Heikinheimo, M. J. Mol. Endocrinol. (2006)
- GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors. Kyrönlahti, A., Rämö, M., Tamminen, M., Unkila-Kallio, L., Butzow, R., Leminen, A., Nemer, M., Rahman, N., Huhtaniemi, I., Heikinheimo, M., Anttonen, M. Endocrinology (2008)
- Identification and validation of an ERBB2 gene expression signature in breast cancers. Bertucci, F., Borie, N., Ginestier, C., Groulet, A., Charafe-Jauffret, E., Adélaïde, J., Geneix, J., Bachelart, L., Finetti, P., Koki, A., Hermitte, F., Hassoun, J., Debono, S., Viens, P., Fert, V., Jacquemier, J., Birnbaum, D. Oncogene (2004)
- Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies. Kasahara, H., Benson, D.W. Cardiovasc. Res. (2004)
- Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes. Takaya, T., Kawamura, T., Morimoto, T., Ono, K., Kita, T., Shimatsu, A., Hasegawa, K. J. Biol. Chem. (2008)
- Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect. Hirayama-Yamada, K., Kamisago, M., Akimoto, K., Aotsuka, H., Nakamura, Y., Tomita, H., Furutani, M., Imamura, S., Takao, A., Nakazawa, M., Matsuoka, R. Am. J. Med. Genet. A (2005)
- Regulation of Ncx1 Expression: IDENTIFICATION OF REGULATORY ELEMENTS MEDIATING CARDIAC-SPECIFIC EXPRESSION AND UP-REGULATION. Xu, L., Renaud, L., M??ller, J.G., Baicu, C.F., Bonnema, D.D., Zhou, H., Kappler, C.S., Kubalak, S.W., Zile, M.R., Conway, S.J., Menick, D.R. J. Biol. Chem. (2006)