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Gene Review

GATA6  -  GATA binding protein 6

Homo sapiens

Synonyms: GATA-binding factor 6, Transcription factor GATA-6
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Disease relevance of GATA6


High impact information on GATA6


Biological context of GATA6


Anatomical context of GATA6


Associations of GATA6 with chemical compounds


Physical interactions of GATA6


Regulatory relationships of GATA6


Other interactions of GATA6

  • Both SF1 and GATA-6 were positive regulators of SULT2A1 promoter constructs [20].
  • Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells [21].
  • We propose that NFY recruits HDACs to the VWF promoter, which may result in deacetylation of GATA6 as well as of histones in non-endothelial cells, thus leading to promoter inactivation [8].
  • The inhibin alpha promoter contains two GATA-binding motifs that can be activated by GATA4 or GATA6 [22].
  • Both GATA4 and GATA6 strongly synergized with LRH-1 [22].

Analytical, diagnostic and therapeutic context of GATA6


  1. Histone modifications silence the GATA transcription factor genes in ovarian cancer. Caslini, C., Capo-chichi, C.D., Roland, I.H., Nicolas, E., Yeung, A.T., Xu, X.X. Oncogene (2006) [Pubmed]
  2. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Akiyama, Y., Watkins, N., Suzuki, H., Jair, K.W., van Engeland, M., Esteller, M., Sakai, H., Ren, C.Y., Yuasa, Y., Herman, J.G., Baylin, S.B. Mol. Cell. Biol. (2003) [Pubmed]
  3. Hypermethylation of the GATA genes in lung cancer. Guo, M., Akiyama, Y., House, M.G., Hooker, C.M., Heath, E., Gabrielson, E., Yang, S.C., Han, Y., Baylin, S.B., Herman, J.G., Brock, M.V. Clin. Cancer Res. (2004) [Pubmed]
  4. Transcription factors GATA-6, SF-1, and cell proliferation in human adrenocortical tumors. Kiiveri, S., Liu, J., Arola, J., Heikkilä, P., Kuulasmaa, T., Lehtonen, E., Voutilainen, R., Heikinheimo, M. Mol. Cell. Endocrinol. (2005) [Pubmed]
  5. GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. Lepore, J.J., Mericko, P.A., Cheng, L., Lu, M.M., Morrisey, E.E., Parmacek, M.S. J. Clin. Invest. (2006) [Pubmed]
  6. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Xin, M., Davis, C.A., Molkentin, J.D., Lien, C.L., Duncan, S.A., Richardson, J.A., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Histone H1-like protein participates in endothelial cell-specific activation of the von Willebrand factor promoter. Wang, X., Peng, Y., Ma, Y., Jahroudi, N. Blood (2004) [Pubmed]
  8. The NFY transcription factor inhibits von Willebrand factor promoter activation in non-endothelial cells through recruitment of histone deacetylases. Peng, Y., Jahroudi, N. J. Biol. Chem. (2003) [Pubmed]
  9. Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells. Ho, C.K., Wood, J.R., Stewart, D.R., Ewens, K., Ankener, W., Wickenheisser, J., Nelson-Degrave, V., Zhang, Z., Legro, R.S., Dunaif, A., McAllister, J.M., Spielman, R., Strauss, J.F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  10. Expression of GATA6 in the human and mouse central nervous system. Kamnasaran, D., Guha, A. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  11. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Gao, X., Sedgwick, T., Shi, Y.B., Evans, T. Mol. Cell. Biol. (1998) [Pubmed]
  12. GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis. Jimenez, P., Saner, K., Mayhew, B., Rainey, W.E. Endocrinology (2003) [Pubmed]
  13. The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. Wood, J.R., Nelson, V.L., Ho, C., Jansen, E., Wang, C.Y., Urbanek, M., McAllister, J.M., Mosselman, S., Strauss, J.F. J. Biol. Chem. (2003) [Pubmed]
  14. Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans. Kiiveri, S., Siltanen, S., Rahman, N., Bielinska, M., Lehto, V.P., Huhtaniemi, I.T., Muglia, L.J., Wilson, D.B., Heikinheimo, M. Mol. Med. (1999) [Pubmed]
  15. GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. Abe, M., Hasegawa, K., Wada, H., Morimoto, T., Yanazume, T., Kawamura, T., Hirai, M., Furukawa, Y., Kita, T. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  16. Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription. Wada, H., Hasegawa, K., Morimoto, T., Kakita, T., Yanazume, T., Abe, M., Sasayama, S. J. Cell Biol. (2002) [Pubmed]
  17. Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha. Umetani, M., Mataki, C., Minegishi, N., Yamamoto, M., Hamakubo, T., Kodama, T. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  18. GATA proteins are potential negative regulators of HDC gene expression in the gastric epithelium. Watson, F., Kiernan, R.S., Dimaline, R. Biochim. Biophys. Acta (2002) [Pubmed]
  19. GATA-6 induces p21(Cip1) expression and G1 cell cycle arrest. Perlman, H., Suzuki, E., Simonson, M., Smith, R.C., Walsh, K. J. Biol. Chem. (1998) [Pubmed]
  20. Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal. Saner, K.J., Suzuki, T., Sasano, H., Pizzey, J., Ho, C., Strauss, J.F., Carr, B.R., Rainey, W.E. Mol. Endocrinol. (2005) [Pubmed]
  21. Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells. Huang, N., Dardis, A., Miller, W.L. Mol. Endocrinol. (2005) [Pubmed]
  22. LRH-1/NR5A2 cooperates with GATA factors to regulate inhibin alpha-subunit promoter activity. Robert, N.M., Miyamoto, Y., Taniguchi, H., Viger, R.S. Mol. Cell. Endocrinol. (2006) [Pubmed]
  23. The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals. Suzuki, E., Evans, T., Lowry, J., Truong, L., Bell, D.W., Testa, J.R., Walsh, K. Genomics (1996) [Pubmed]
  24. Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation. Kimchi, E.T., Posner, M.C., Park, J.O., Darga, T.E., Kocherginsky, M., Karrison, T., Hart, J., Smith, K.D., Mezhir, J.J., Weichselbaum, R.R., Khodarev, N.N. Cancer Res. (2005) [Pubmed]
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