- Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy. Davis, F.J., Gupta, M., Camoretti-Mercado, B., Schwartz, R.J., Gupta, M.P. J. Biol. Chem. (2003)