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Gene Review

Camk4  -  calcium/calmodulin-dependent protein...

Rattus norvegicus

Synonyms: CaM kinase-GR, CaMK IV, Calcium/calmodulin-dependent protein kinase type IV, Calspermin, Ccdpk, ...
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Disease relevance of Camk4

  • When cDNA for rat brain CaM-kinase IV was expressed in Escherichia coli, the enzyme was produced in a good yield, but it did not show significant activity [1].
  • Antisense CCDPK ODN treatment at 2 wk after injury resulted in a significant inhibition of intima hyperplasia, compared with untreated vessels [2].
  • CONCLUSION: SPD protected striatal neurons against ischemic injury and antagonized the inhibitory action on CCDPK activity induced by ischemia [3].
  • RESULTS: Under anoxia for 30 min, the CCDPK II activity decreased to 29.2% and 27.0% of the control in rat hippocampal and striatal slices, respectively [4].

Psychiatry related information on Camk4


High impact information on Camk4

  • Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription [6].
  • Calcium-dependent dendritic growth is suppressed by CaM kinase inhibitors, a constitutively active form of CaM kinase IV induces dendritic growth in the absence of extracellular stimulation, and a kinase-dead form of CaM kinase IV suppresses dendritic growth induced by calcium influx [6].
  • These mechanisms, which implicate CaM kinase IV and CREB in the control of BDNF expression, are likely to be centrally involved in activity-dependent plasticity during development [7].
  • The portion of sequence that extended from the hypothesized calmodulin-binding domain to the carboxyl terminus of the protein was identical at both the amino acid and nucleotide level to the noncatalytic, calmodulin-binding protein calspermin from rat testis [8].
  • The deduced amino acid sequence was confirmed by comparison with the peptide sequence from purified CaM kinase Gr [8].

Chemical compound and disease context of Camk4


Biological context of Camk4


Anatomical context of Camk4


Associations of Camk4 with chemical compounds


Enzymatic interactions of Camk4

  • In parallel fashion to its activation, CaM kinase IV is phosphorylated in a CaM kinase Ia kinase-, Ca(2+)-CaM-, and MgATP-dependent manner [17].
  • Present study revealed that CaMKK also phosphorylated CaM kinase IV associated with the activation of its activity [20].

Regulatory relationships of Camk4


Other interactions of Camk4


Analytical, diagnostic and therapeutic context of Camk4


  1. Requirement of brain extract for the activity of brain calmodulin-dependent protein kinase IV expressed in Escherichia coli. Okuno, S., Fujisawa, H. J. Biochem. (1993) [Pubmed]
  2. Prevention of intima hyperplasia by mitogen-activated protein kinase antisense oligodeoxynucleotide. Huang, S.L., Ding, B., Shan, B., Yu, Q.S., Guo, Z.G. Acta Pharmacol. Sin. (2000) [Pubmed]
  3. Antagonistic effect of l-stepholidine on striatal ischemic injury in rat. Tang, F.M., Ding, Y.M., Chen, Y.T., Sun, Y.F., Wang, R., Zhang, G.Y., Jin, G.Z. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999) [Pubmed]
  4. Protection of dopaminergic antagonists against anoxia-induced inhibition of Ca(2+)-calmodulin dependent protein kinase II activity in rat brain. Hou, X.Y., Zhang, G.Y. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999) [Pubmed]
  5. Effects of voluntary ethanol intake on the expression of Ca(2+) /calmodulin-dependent protein kinase IV and on CREB expression and phosphorylation in the rat nucleus accumbens. Misra, K., Roy, A., Pandey, S.C. Neuroreport (2001) [Pubmed]
  6. Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Redmond, L., Kashani, A.H., Ghosh, A. Neuron (2002) [Pubmed]
  7. Identification of a signaling pathway involved in calcium regulation of BDNF expression. Shieh, P.B., Hu, S.C., Bobb, K., Timmusk, T., Ghosh, A. Neuron (1998) [Pubmed]
  8. Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene. Ohmstede, C.A., Bland, M.M., Merrill, B.M., Sahyoun, N. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  9. Comparison of Ca2+/calmodulin-dependent protein kinase IV from rat brain, expressed in insect cells, and expressed in Escherichia coli. Kitani, T., Okuno, S., Fujisawa, H. J. Biochem. (1995) [Pubmed]
  10. A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. Means, A.R., Cruzalegui, F., LeMagueresse, B., Needleman, D.S., Slaughter, G.R., Ono, T. Mol. Cell. Biol. (1991) [Pubmed]
  11. Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase. Tokumitsu, H., Brickey, D.A., Glod, J., Hidaka, H., Sikela, J., Soderling, T.R. J. Biol. Chem. (1994) [Pubmed]
  12. Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein. Ono, T., Slaughter, G.R., Cook, R.G., Means, A.R. J. Biol. Chem. (1989) [Pubmed]
  13. Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene. Sun, Z., Means, R.L., LeMagueresse, B., Means, A.R. J. Biol. Chem. (1995) [Pubmed]
  14. Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex. Pandey, S.C., Roy, A., Mittal, N. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  15. Effects of estrogen treatment on expression of brain-derived neurotrophic factor and cAMP response element-binding protein expression and phosphorylation in rat amygdaloid and hippocampal structures. Zhou, J., Zhang, H., Cohen, R.S., Pandey, S.C. Neuroendocrinology (2005) [Pubmed]
  16. Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study. Nakamura, Y., Okuno, S., Kitani, T., Otake, K., Sato, F., Fujisawa, H. Neurosci. Lett. (1996) [Pubmed]
  17. Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. Selbert, M.A., Anderson, K.A., Huang, Q.H., Goldstein, E.G., Means, A.R., Edelman, A.M. J. Biol. Chem. (1995) [Pubmed]
  18. Full activation of brain calmodulin-dependent protein kinase IV requires phosphorylation of the amino-terminal serine-rich region by calmodulin-dependent protein kinase IV kinase. Okuno, S., Kitani, T., Fujisawa, H. J. Biochem. (1995) [Pubmed]
  19. Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades. Tiraboschi, E., Tardito, D., Kasahara, J., Moraschi, S., Pruneri, P., Gennarelli, M., Racagni, G., Popoli, M. Neuropsychopharmacology (2004) [Pubmed]
  20. Ca2+/calmodulin-dependent protein kinase kinase cascade. Sugita, R., Mochizuki, H., Ito, T., Yokokura, H., Kobayashi, R., Hidaka, H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  21. Antisense Ca(2+)-calmodulin dependent protein kinase oligonucleotide inhibits bFGF-induced proliferation of rat vascular smooth muscle cells. Huang, S.L., Ding, B., Li, J., Yu, Q.S., Guo, Z.G. Acta Pharmacol. Sin. (2000) [Pubmed]
  22. Activation of Ca2+/calmodulin-dependent protein kinase I in cultured rat hippocampal neurons. Uezu, A., Fukunaga, K., Kasahara, J., Miyamoto, E. J. Neurochem. (2002) [Pubmed]
  23. High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. Lankisch, T.O., Nozu, F., Owyang, C., Tsunoda, Y. Eur. J. Cell Biol. (1999) [Pubmed]
  24. Platelet-derived growth factor stimulated vascular smooth muscle cell proliferation and its molecular mechanism. Li, J., Huang, S.L., Guo, Z.G. Acta Pharmacol. Sin. (2000) [Pubmed]
  25. Regulation of CBP-mediated transcription by neuronal calcium signaling. Hu, S.C., Chrivia, J., Ghosh, A. Neuron (1999) [Pubmed]
  26. Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain. Okuno, S., Kitani, T., Fujisawa, H. J. Biochem. (1996) [Pubmed]
  27. Effect of PKC-zeta mediating Ang II-stimulated activation of CCDPK on rat cardiac fibroblast proliferation. Ding, B., Huang, S.L., Zhang, S.Q., Li, Y.X. Acta Pharmacol. Sin. (2000) [Pubmed]
  28. Preparation and characterization of calmodulin-dependent protein kinase IV (CaM-kinase IV) free of CaM-kinase IV kinase from rat cerebral cortex. Kameshita, I., Fujisawa, H. J. Biochem. (1995) [Pubmed]
  29. Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat T cells. Pahlavani, M.A., Vargas, D.M. Proc. Soc. Exp. Biol. Med. (2000) [Pubmed]
  30. Estrogen affects the expression of Ca2+/calmodulin-dependent protein kinase IV in amygdala. Zhou, J., Cohen, R.S., Pandey, S.C. Neuroreport (2001) [Pubmed]
  31. Immunohistochemical localization of Ca2+/calmodulin-dependent protein kinase type IV in the mature and developing rat retina. Sakagami, H., Kondo, H. Brain Res. (1996) [Pubmed]
  32. Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy. Ji, R.R., Shi, T.J., Xu, Z.Q., Zhang, Q., Sakagami, H., Tsubochi, H., Kondo, H., Hökfelt, T. Brain Res. (1996) [Pubmed]
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