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Tojo, M. et al.

Tojo, Zheng, Yanagihori, Oyama, Takahashi, Nakamura, Kaneko,

Detection of herpes virus genomes in skin lesions from patients with BehÃ§et's disease and other related inflammatory diseases.

Although the aetiology of BehÃ§et's disease is still poorly understood, viral infection has long been postulated as one of the factors. To investigate the relationship between herpes viruses and BehÃ§et's disease, we used polymerase chain reaction to detect herpes simplex virus 1 (HSV-1) and 2 (HSV-2), and human herpes virus 6 (HHV-6) and 7 (HHV-7) DNA in samples of lesional tissues from patients with BehÃ§et's disease and other related inflammatory disorders. Four cases were positive for HSV-1; 1 of 11 BehÃ§et's disease cases, 2 of 3 Sweet's disease cases and 1 of 3 erythema nodosum cases. Two cases were positive for both HSV-1 and HSV-2; one BehÃ§et's disease and one erythema nodosum. All cases were negative for HHV-6 and HHV-7. These findings indicate that there might be some relationship between BehÃ§et's disease and the presence of HSV-1 and/or HSV-2 DNA and that HHV-6 and HHV-7 do not seem to be involved in the pathogenesis of BehÃ§et's disease. However, HSV-1 and HSV-2 DNAs were also detected in non-BehÃ§et's disease lesions, suggesting that HSV-1/2 is not correlated to the direct pathogenesis of BehÃ§et's disease.[1]

References

Detection of herpes virus genomes in skin lesions from patients with Behçet's disease and other related inflammatory diseases. Tojo, M., Zheng, X., Yanagihori, H., Oyama, N., Takahashi, K., Nakamura, K., Kaneko, F. Acta Derm. Venereol. (2003) [Pubmed]

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