- A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production. Grosenbach, D.W., Schlom, J., Gritz, L., Gómez Yafal, A., Hodge, J.W. Cell. Immunol. (2003)