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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

AHP2 is required for bivalent formation and for segregation of homologous chromosomes in Arabidopsis meiosis.

A new Arabidopsis meiotic mutant has been isolated. Homozygous ahp2-1 (Arabidopsis homologue pairing 2) plants were sterile because of failure of both male and female gametophyte development. Fluorescent in situ hybridisation showed that in ahp2-1 male meiocytes, chromosomes did not form bivalents during prophase I and instead seemed to associate indiscriminately. Chromosome fragmentation, chromatin bridges and unbalanced segregation were seen in anaphase I and anaphase II. The ahp2-1 mutation was caused by a T-DNA insertion in an Arabidopsis homologue of meu13+, which has been implicated in homologous chromosome pairing during meiosis in Schizosaccharomyces pombe. Our results suggest that meu13+ function is conserved in higher eukaryotes and support the idea that Arabidopsis, yeast and mouse share a pairing pathway that is not present in Drosophila melanogaster and Caenorhabditis elegans.[1]

References

  1. AHP2 is required for bivalent formation and for segregation of homologous chromosomes in Arabidopsis meiosis. Schommer, C., Beven, A., Lawrenson, T., Shaw, P., Sablowski, R. Plant J. (2003) [Pubmed]
 
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