Fatal fulminant hypereosinophilic syndrome with a petechial rash in a 16-year-old girl.
Peripheral blood eosinophilia and eosinophilic tissue infiltration characterize the hypereosinophilic syndrome, which if untreated can be fatal. Its manifestations are protean. Often a diagnosis of exclusion, it presents diagnostic challenges. A fatal case of hypereosinophilic syndrome in a 16-year-old girl with petechiae, edema, urticaria, and diffuse erythema unfolded over 2 weeks. The histopathology of the petechiae demonstrated an eosinophilic and mixed cell interstitial and perivascular infiltrate and microthrombi in vessels. There was no evidence of T-cell clonality. Despite treatment with cyclosporine and methylprednisolone, she died. The age group; fulminant, fatal course without neoplasia; striking eosinophilia; and petechial rash are notable.[1]References
- Fatal fulminant hypereosinophilic syndrome with a petechial rash in a 16-year-old girl. Scheinfeld, N. J. Pediatr. Hematol. Oncol. (2003) [Pubmed]
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