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Jayakumar, P.N. et al.

Jayakumar, Srikanth, Chandrashekar, Kovoor, Shankar, Anandh,

Pyruvate: an in vivo marker of cestodal infestation of the human brain on proton MR spectroscopy.

PURPOSE: To study intracranial cestodal cysts using in vivo proton magnetic resonance spectroscopy ((1)H MRS) in an effort to identify metabolite(s) that may help in recognizing the parasitic etiology and, perhaps, viability of such tapeworm cysts. Cestodal infestations of the human central nervous system (CNS)-cysticercosis and hydatidosis-are not rare. Identification of a scolex is considered diagnostic of cysticercosis on imaging. In its absence, however, the features are non-specific. MATERIALS AND METHODS: Three patients with intracranial hydatid cysts and 13 patients with intracranial cysticercal cysts (four intraventricular, seven parenchymal, and two subarachnoid racemose cysts) were studied on a 1.5-T MR system. In vivo (1)H MRS was performed by multivoxel two-dimensional hybrid chemical shift imaging technique (TE = 135 msec). In vitro (1)H NMR and mass spectroscopy (matrix assisted laser desorption/ionization [MALDI]) were performed on excised cysticercal and hydatid cyst fluid. MALDI spectra for pyruvate and succinate were also obtained. RESULTS: Alanine, pyruvate, and acetate were seen in all the three hydatid cysts. Lactate was seen in racemose cysticercal cysts. A large resonance at 2.4 ppm, confirmed as pyruvate at mass spectroscopy, was seen in 13 cestodal cysts. Pyruvate was not seen in one each of racemose, intraventricular, and parenchymal cysticercal cysts. CONCLUSION: Pyruvate is the predominant metabolite in cestodal cysts infesting the human CNS. It may be a marker of parasitic etiology and perhaps that of viability of such intracranial cysts.[1]

References

Pyruvate: an in vivo marker of cestodal infestation of the human brain on proton MR spectroscopy. Jayakumar, P.N., Srikanth, S.G., Chandrashekar, H.S., Kovoor, J.M., Shankar, S.K., Anandh, B. Journal of magnetic resonance imaging : JMRI. (2003) [Pubmed]

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