Disease relevance of Cysticercosis

• Cysticercosis was diagnosed in 12 US citizens who had no history of travel to countries considered traditionally endemic for Taenia solium taeniasis/cysticercosis [1].
• We assessed the following possible risk factors: arterial hypertension, diabetes, cardiopathy, high levels of cholesterol and triglycerides, smoking, alcohol abuse, and cerebral cysticercosis [2].
• Moreover, simultaneous administration of praziquantel and cimetidine could improve further the efficacy of the single-day therapy for cysticercosis and other parasitic diseases, such as schistosomiasis [3].
• Sequential expression of the neuropeptides substance P and somatostatin in granulomas associated with murine cysticercosis [4].
• The H. nana ELISA had a high rate of cross-reactions with sera from patients with cysticercosis (8 of 29 [28%]) and hydatidosis (8 of 23 [35%]) [5].

Psychiatry related information on Cysticercosis

• Time-response curve of oxfendazole in the treatment of swine cysticercosis [6].

High impact information on Cysticercosis

• In countries where cysticercosis is endemic, the proportion of epilepsy due to cysticercosis is not well documented [7].
• False-positive tuberculostearic acid tests in cysticercosis [8].
• Cerebral cysticercosis treated biphasically with dexamethasone and praziquantel [9].
• Here, Marshall Lightowlers and colleagues review the substantial progress that has been made towards developing practical vaccines against hydatid disease in sheep and cysticercosis in sheep and cattle [10].
• In BALB/cAnN x (C57BL/6J x BALB/cAnN)F1 and BALB/cAnN x (BALB/cJ x BALB/cAnN)F1 backcrosses, the expression of Qa-2 antigen correlated with resistance to cysticercosis [11].

Chemical compound and disease context of Cysticercosis

• Praziquantel and albendazole have been recently described as effective drugs for treating cysticercosis of the brain [12].
• We identified seven major glycoprotein bands that are commonly recognized by virtually all serum and/or CSF samples from patients with confirmed cysticercosis [13].
• Five hundred patients with cysticercosis of the nervous system were evaluated by scanning that used anti-Cysticercus antibodies labeled with indium 113 [14].
• METHODS: In this open-label, randomized, prospective follow-up study, 97 patients with new-onset seizures and a single enhancing computed tomography (CT)-detected lesion of cysticercosis were randomly divided in two groups to receive either antiepileptic monotherapy alone (n = 48) or antiepileptic monotherapy with prednisolone (n = 49) [15].
• Effective, single-dose treatment or porcine cysticercosis with oxfendazole [16].

Biological context of Cysticercosis

• Cross-reactions to the 8-, 16-, and 21-kDa bands occurred, respectively, in 12, 4, and 4% of sera from patients with cysticercosis [17].
• Human cysticercosis, an infection caused by larvae of Taenia solium, is a major public health problem in many developing countries [18].
• The implications of the results to the epidemiology of human hydatid diseases caused by Echinococcus granulosus and E. multilocularis as well as of T. solium cysticercosis are discussed [19].
• This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis [20].
• First, we followed the kinetics of antibody responses against these two diagnostic proteins in pigs with cysticercosis that were treated with oxfendazole [21].

Anatomical context of Cysticercosis

• Central nervous system cysticercosis is common in countries where Taenia solium occurs in pigs and the level of hygiene and sanitation is low [22].
• Dot-immunogold-silver staining (Dot-IGSS) and Dot-ELISA were used, with Taenia solium cyst fluid antigen, to detect specific antibodies in the sera of patients with cysticercosis [23].
• CONCLUSION: Corticosteroids should be given in addition to albendazole in the treatment of orbital cysticercosis when cysts are in close proximity to the optic nerve [24].

Gene context of Cysticercosis

• Thus, early granulomas in cysticercosis are predominantly associated with a Th1 response, whereas later granulomas, in which parasite destruction is complete, have a mixture of Th1 and IL-4 [25].
• Thus, the Th1-type immune response plays a fundamental role in protection against Taenia crassiceps cysticercosis, whereas Th2, at least through IL-10, favors parasite establishment [26].
• Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis [27].
• These results suggest a role for both IL-6 and MIF genes in sex-associated susceptibility in murine T. crassiceps cysticercosis [28].
• Do interleukin-6 and macrophage-migration inhibitory factor play a role during sex-associated susceptibility in murine cysticercosis [28]?

Analytical, diagnostic and therapeutic context of Cysticercosis

• Taenia crassiceps recombinant antigens KETc1 and KETc12 have been shown to induce high level of protection against experimental murine T. crassiceps cysticercosis, an experimental model successfully used to test candidate antigens for use in vaccination against porcine Taenia solium cysticercosis [29].
• Ninety of 100 participants identified with active epilepsy underwent a neurologic examination, video-electroencephalography (video-EEG), brain computed tomography (CT) scan, and serum enzyme-linked immunoelectrotransfer blot (EITB) for cysticercosis [30].
• This study examined the seroprevalence and serum antibody isotype profile for Taenia solium cysticercosis in an Amerindian community in the Amazonas state of Venezuela [31].
• A Western blot assay for identification of 26 kDa and/or 8 kDa antigens in a crude saline extract (CSE) of Taenia solium metacestodes, previously developed for human cysticercosis, was evaluated for use with pigs [32].
• A population-based, case-control study of Taenia solium taeniasis and cysticercosis [33].

References