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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats.

Recent reports have demonstrated effectiveness of melanocortin antagonists as potent analgesics, and have suggested that the spinal melanocortin 4 receptor (MC4-R) mediates their effects on pain transmission. These findings prompted us to investigate the changes in MC4-R mRNA level in the spinal cord and dorsal root ganglia (DRG) of neuropathic animals at different time points after sciatic nerve injury by quantitative real-time PCR. The spinal MC4-R mRNA level was not affected by sciatic nerve injury. In contrast, down-regulation of MC4-R mRNA in DRG developed 2 weeks after the injury and was parallel with the attenuated effectiveness of MC4-R ligands in neuropathic animals. The MC4-R adaptation in DRG observed in neuropathic rats indicates their important role in presynaptic modulation of activity of the primary afferents in neuropathic pain.[1]

References

  1. Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats. Starowicz, K., Bilecki, W., Sieja, A., Przewlocka, B., Przewlocki, R. Neurosci. Lett. (2004) [Pubmed]
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