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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Regional differences in blood-nerve barrier function and tight-junction protein expression within the rat dorsal root ganglion.

To elucidate blood-nerve barrier function and tight-junction protein expression in the dorsal root ganglion (DRG), we analyzed the vascular permeability in the rat DRG by i.v. administration of fluorescent Evans-blue albumin (EBA) and compared it with the localization of claudin-1, claudin-5, and occludin by immunoconfocal microscopy. In the cell body-rich area within the DRG, extravascular leakage of EBA was noted and claudin-5 but neither claudin-1 nor occludin was detected. Conversely, in the nerve fiber-rich area within the DRG, no extravascular leakage of EBA was observed and both claudin-5 and occludin but no claudin-1 were detected in the blood vessel. These results demonstrate regional differences in the blood-nerve barrier function and tight-junction protein expression within the DRG.[1]

References

  1. Regional differences in blood-nerve barrier function and tight-junction protein expression within the rat dorsal root ganglion. Hirakawa, H., Okajima, S., Nagaoka, T., Kubo, T., Takamatsu, T., Oyamada, M. Neuroreport (2004) [Pubmed]
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