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Gene Review

Ocln  -  occludin

Rattus norvegicus

Synonyms: Occludin
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Disease relevance of Ocln


High impact information on Ocln


Chemical compound and disease context of Ocln


Biological context of Ocln


Anatomical context of Ocln


Associations of Ocln with chemical compounds


Regulatory relationships of Ocln

  • In conclusion, in vitro BBB model studies revealed that the pericyte-derived multimeric angiopoietin-1/Tie-2 pathway induces occludin expression [11].
  • Introduction of occludin by transfection induced clear junctional expression of occludin with few or no changes of expression of E-cadherin and ZO-1 [20].
  • Continuous intracerebroventricular infusion of an antisense morpholino oligonucleotide targeted to occludin mRNA reversed n-3 PUFA-induced insensitivity to peripherally administered leptin [21].

Other interactions of Ocln


Analytical, diagnostic and therapeutic context of Ocln

  • Transfilter co-culture with TR-AST4 cells, and exposure to conditioned medium of TR-AST4 cells (AST-CM) or TR-PCT1 cells (PCT-CM) increased occludin mRNA in TR-BBB13 cells [11].
  • An apparent increase of occludin mRNA expression was detected in livers after 6 h ligation, whereas the expression of claudin-1, -2, and -3 was not influenced by ligation [12].
  • Confocal microscopy demonstrated continuous expression of both occludin and JAM-1, each co-localizing with ZO-1 [24].
  • At 8 days (D8) after the first dose, testicular expression of the occludin, claudin-1, and -11 was analyzed by semiquantitative RT-PCR [25].
  • Furthermore, we found that the anti-chicken occludin mAb, Oc-3, did not recognize the predominant lower Mr bands of occludin (non- or less phosphorylated form) but was specific to the higher Mr bands (phosphorylated form) on immunoblotting [8].


  1. Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis. Asaoka, D., Miwa, H., Hirai, S., Ohkawa, A., Kurosawa, A., Kawabe, M., Hojo, M., Nagahara, A., Minoo, T., Ohkura, R., Ohkusa, T., Sato, N. J. Gastroenterol. (2005) [Pubmed]
  2. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Mark, K.S., Davis, T.P. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  3. Regional differences in blood-nerve barrier function and tight-junction protein expression within the rat dorsal root ganglion. Hirakawa, H., Okajima, S., Nagaoka, T., Kubo, T., Takamatsu, T., Oyamada, M. Neuroreport (2004) [Pubmed]
  4. Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity. Schmitt, M., Kubitz, R., Lizun, S., Wettstein, M., Häussinger, D. Hepatology (2001) [Pubmed]
  5. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Antonetti, D.A., Barber, A.J., Khin, S., Lieth, E., Tarbell, J.M., Gardner, T.W. Diabetes (1998) [Pubmed]
  6. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. Li, D., Mrsny, R.J. J. Cell Biol. (2000) [Pubmed]
  7. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. Yamamoto, T., Harada, N., Kano, K., Taya, S., Canaani, E., Matsuura, Y., Mizoguchi, A., Ide, C., Kaibuchi, K. J. Cell Biol. (1997) [Pubmed]
  8. Possible involvement of phosphorylation of occludin in tight junction formation. Sakakibara, A., Furuse, M., Saitou, M., Ando-Akatsuka, Y., Tsukita, S. J. Cell Biol. (1997) [Pubmed]
  9. Experimental colitis increases small intestine permeability in the rat. Fries, W., Mazzon, E., Squarzoni, S., Martin, A., Martines, D., Micali, A., Sturniolo, G.C., Citi, S., Longo, G. Lab. Invest. (1999) [Pubmed]
  10. Cerebral ischemia enhances tyrosine phosphorylation of occludin in brain capillaries. Kago, T., Takagi, N., Date, I., Takenaga, Y., Takagi, K., Takeo, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  11. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. Hori, S., Ohtsuki, S., Hosoya, K., Nakashima, E., Terasaki, T. J. Neurochem. (2004) [Pubmed]
  12. Bile canalicular barrier function and expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation. Takakuwa, Y., Kokai, Y., Sasaki, K., Chiba, H., Tobioka, H., Mori, M., Sawada, N. Cell Tissue Res. (2002) [Pubmed]
  13. S-methylation of 2-mercaptopyrazine in rat liver microsomes and cytosol. Lee, D.H., Kim, D.H. Xenobiotica (1999) [Pubmed]
  14. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. Antonetti, D.A., Barber, A.J., Hollinger, L.A., Wolpert, E.B., Gardner, T.W. J. Biol. Chem. (1999) [Pubmed]
  15. Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands. Peppi, M., Ghabriel, M.N. J. Anat. (2004) [Pubmed]
  16. Tight junctions in differentiating ameloblasts and odontoblasts differentially express ZO-1, occludin, and claudin-1 in early odontogenesis of rat molars. João, S.M., Arana-Chavez, V.E. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2004) [Pubmed]
  17. cAMP perturbs inter-Sertoli tight junction permeability barrier in vitro via its effect on proteasome-sensitive ubiquitination of occludin. Lui, W.Y., Lee, W.M. J. Cell. Physiol. (2005) [Pubmed]
  18. The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosa. Hussar, P., Tserentsoodol, N., Koyama, H., Yokoo-Sugawara, M., Matsuzaki, T., Takami, S., Takata, K. Chem. Senses (2002) [Pubmed]
  19. Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression. Chehade, J.M., Haas, M.J., Mooradian, A.D. Neurochem. Res. (2002) [Pubmed]
  20. Occludin regulates actin cytoskeleton in endothelial cells. Kuwabara, H., Kokai, Y., Kojima, T., Takakuwa, R., Mori, M., Sawada, N. Cell Struct. Funct. (2001) [Pubmed]
  21. Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain. Oh-I, S., Shimizu, H., Sato, T., Uehara, Y., Okada, S., Mori, M. Cell metabolism. (2005) [Pubmed]
  22. Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction. Calabria, A.R., Weidenfeller, C., Jones, A.R., de Vries, H.E., Shusta, E.V. J. Neurochem. (2006) [Pubmed]
  23. The temporospatial expression of peripheral myelin protein 22 at the developing blood-nerve and blood-brain barriers. Roux, K.J., Amici, S.A., Notterpek, L. J. Comp. Neurol. (2004) [Pubmed]
  24. Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain. Brooks, T.A., Ocheltree, S.M., Seelbach, M.J., Charles, R.A., Nametz, N., Egleton, R.D., Davis, T.P. Brain Res. (2006) [Pubmed]
  25. Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions. Gye, M.C., Ohsako, S. Toxicol. Lett. (2003) [Pubmed]
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