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Gene Review

Cldn1  -  claudin 1

Rattus norvegicus

Synonyms: Claudin-1
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Disease relevance of Cldn1


High impact information on Cldn1

  • These novel results provide direct evidence of the pivotal role of the claudin family in generating the paracellular physical barrier of tight junctions necessary for spermatogenesis and normal CNS function [3].
  • In the pancreas, claudin 2 is only detected in junctions of the duct epithelia, claudin 5 only in junctions of acinar cells, whereas claudin 3 and 4 are in both [4].
  • Among differences in the gut are a crypt-to-villus decrease in claudin 2, a highly restricted expression of claudin 4 to colonic surface cells, and the finding that some claudins can be junctional, lateral, or show a gradient in junctional vs. lateral localization along the crypt-to-villus surface axis [4].
  • Exogenously expressed JEAP co-localized with ZO-1 and occludin at TJs in polarized Madin-Darby canine kidney cells, but not with claudin-1, JAM, or ZO-1 in L cells [5].
  • Neighboring cells formed tight and gap junctions characteristic of epididymal cells in vivo and expressed tight (occludin and claudin-1, -3, and -4) and gap junctional proteins (connexin-26, -30.3, -32, and -43) [6].

Biological context of Cldn1


Anatomical context of Cldn1


Associations of Cldn1 with chemical compounds


Regulatory relationships of Cldn1


Other interactions of Cldn1


Analytical, diagnostic and therapeutic context of Cldn1


  1. Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis. Asaoka, D., Miwa, H., Hirai, S., Ohkawa, A., Kurosawa, A., Kawabe, M., Hojo, M., Nagahara, A., Minoo, T., Ohkura, R., Ohkusa, T., Sato, N. J. Gastroenterol. (2005) [Pubmed]
  2. Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver. Kojima, T., Yamamoto, T., Murata, M., Lan, M., Takano, K., Go, M., Ichimiya, S., Chiba, H., Sawada, N. Cell Commun. Adhes. (2003) [Pubmed]
  3. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Gow, A., Southwood, C.M., Li, J.S., Pariali, M., Riordan, G.P., Brodie, S.E., Danias, J., Bronstein, J.M., Kachar, B., Lazzarini, R.A. Cell (1999) [Pubmed]
  4. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Rahner, C., Mitic, L.L., Anderson, J.M. Gastroenterology (2001) [Pubmed]
  5. JEAP, a novel component of tight junctions in exocrine cells. Nishimura, M., Kakizaki, M., Ono, Y., Morimoto, K., Takeuchi, M., Inoue, Y., Imai, T., Takai, Y. J. Biol. Chem. (2002) [Pubmed]
  6. Characterization of a novel rat epididymal cell line to study epididymal function. Dufresne, J., St-Pierre, N., Viger, R.S., Hermo, L., Cyr, D.G. Endocrinology (2005) [Pubmed]
  7. Tight junctions in differentiating ameloblasts and odontoblasts differentially express ZO-1, occludin, and claudin-1 in early odontogenesis of rat molars. João, S.M., Arana-Chavez, V.E. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2004) [Pubmed]
  8. Bile canalicular barrier function and expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation. Takakuwa, Y., Kokai, Y., Sasaki, K., Chiba, H., Tobioka, H., Mori, M., Sawada, N. Cell Tissue Res. (2002) [Pubmed]
  9. p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes. Yamamoto, T., Kojima, T., Murata, M., Takano, K., Go, M., Hatakeyama, N., Chiba, H., Sawada, N. J. Hepatol. (2005) [Pubmed]
  10. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. Chen, S.P., Zhou, B., Willis, B.C., Sandoval, A.J., Liebler, J.M., Kim, K.J., Ann, D.K., Crandall, E.D., Borok, Z. J. Appl. Physiol. (2005) [Pubmed]
  11. Heterogeneity in expression and subcellular localization of tight junction proteins, claudin-10 and -15, examined by RT-PCR and immunofluorescence microscopy. Inai, T., Sengoku, A., Guan, X., Hirose, E., Iida, H., Shibata, Y. Arch. Histol. Cytol. (2005) [Pubmed]
  12. Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands. Peppi, M., Ghabriel, M.N. J. Anat. (2004) [Pubmed]
  13. Heterogeneity of claudin expression by alveolar epithelial cells. Wang, F., Daugherty, B., Keise, L.L., Wei, Z., Foley, J.P., Savani, R.C., Koval, M. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  14. Developmental changes in proximal tubule tight junction proteins. Haddad, M., Lin, F., Dwarakanath, V., Cordes, K., Baum, M. Pediatr. Res. (2005) [Pubmed]
  15. Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB. Brown, R.C., Mark, K.S., Egleton, R.D., Huber, J.D., Burroughs, A.R., Davis, T.P. J. Cell. Sci. (2003) [Pubmed]
  16. Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Yi, X., Wang, Y., Yu, F.S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  17. Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C. Lippoldt, A., Liebner, S., Andbjer, B., Kalbacher, H., Wolburg, H., Haller, H., Fuxe, K. Neuroreport (2000) [Pubmed]
  18. Regional differences in blood-nerve barrier function and tight-junction protein expression within the rat dorsal root ganglion. Hirakawa, H., Okajima, S., Nagaoka, T., Kubo, T., Takamatsu, T., Oyamada, M. Neuroreport (2004) [Pubmed]
  19. Functional analysis for peripheral myelin protein PASII/PMP22: is it a member of claudin superfamily? Takeda, Y., Notsu, T., Kitamura, K., Uyemura, K. Neurochem. Res. (2001) [Pubmed]
  20. Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells. Liebner, S., Kniesel, U., Kalbacher, H., Wolburg, H. Eur. J. Cell Biol. (2000) [Pubmed]
  21. Effects of flutamide in the rat testis on the expression of occludin, an integral member of the tight junctions. Gye, M.C., Ohsako, S. Toxicol. Lett. (2003) [Pubmed]
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