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Gene Review

Cldn5  -  claudin 5

Rattus norvegicus

Synonyms: Claudin-5
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Disease relevance of Cldn5


High impact information on Cldn5


Biological context of Cldn5

  • This suggests that reduced expression of claudin-5 plays a crucial role in the increased ovarian vascular permeability seen in OHSS and that its expression can be modulated by GnRHa treatment [1].

Anatomical context of Cldn5


Associations of Cldn5 with chemical compounds

  • To clarify the biological significance of this site in regulation of endothelial barrier functions, we established rat lung endothelial (RLE) cells expressing doxycycline (Dox)-inducible wild-type claudin-5 and a mutant with a substitution of Ala for Thr(207) (CL5T207A) [4].
  • We show that induction of wild-type claudin-5 is sufficient to reconstitute the paracellular barrier against inulin (5 kDa), but not mannitol (182 Da), in leaky RLE cells [4].
  • Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5 [1].

Regulatory relationships of Cldn5


Other interactions of Cldn5

  • Presumably, some of these proteins (e.g., occludin, claudin-5 and ZO-1) could be considered sensitive indicators of normal and also of disturbed functional state of the BBB [10].
  • This study investigates the effect in the rat of chronic CdCl2 intoxication (500 microg Cd2+/kg, daily i.p. injection for 5 days) on renal function and the changes in tight junction proteins claudin-2, claudin-3, and claudin-5 present in rat kidney [11].
  • Alteration of BBB related genes, such as those encoding p-glycoprotein, aquaporin-4, and claudin-5, was assessed at the protein and mRNA levels in the brain after local exposure of the head to EMF at 0, 2, and 6 W/kg specific energy absorption rates (SARs) for 90 min/day for 1 or 2 weeks [12].

Analytical, diagnostic and therapeutic context of Cldn5


  1. Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5. Kitajima, Y., Endo, T., Nagasawa, K., Manase, K., Honnma, H., Baba, T., Hayashi, T., Chiba, H., Sawada, N., Saito, T. Endocrinology (2006) [Pubmed]
  2. Regional differences in blood-nerve barrier function and tight-junction protein expression within the rat dorsal root ganglion. Hirakawa, H., Okajima, S., Nagaoka, T., Kubo, T., Takamatsu, T., Oyamada, M. Neuroreport (2004) [Pubmed]
  3. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., Tsukita, S. J. Cell Biol. (2003) [Pubmed]
  4. Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP. Soma, T., Chiba, H., Kato-Mori, Y., Wada, T., Yamashita, T., Kojima, T., Sawada, N. Exp. Cell Res. (2004) [Pubmed]
  5. Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction. Calabria, A.R., Weidenfeller, C., Jones, A.R., de Vries, H.E., Shusta, E.V. J. Neurochem. (2006) [Pubmed]
  6. Amyloid beta-peptide1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells. Marco, S., Skaper, S.D. Neurosci. Lett. (2006) [Pubmed]
  7. Reversible disruption of tight junction complexes in the rat blood-brain barrier, following transitory focal astrocyte loss. Willis, C.L., Leach, L., Clarke, G.J., Nolan, C.C., Ray, D.E. Glia (2004) [Pubmed]
  8. Heterogeneity of claudin expression by alveolar epithelial cells. Wang, F., Daugherty, B., Keise, L.L., Wei, Z., Foley, J.P., Savani, R.C., Koval, M. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  9. Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C. Lippoldt, A., Liebner, S., Andbjer, B., Kalbacher, H., Wolburg, H., Haller, H., Fuxe, K. Neuroreport (2000) [Pubmed]
  10. Immunogold localization of tight junctional proteins in normal and osmotically-affected rat blood-brain barrier. Dobrogowska, D.H., Vorbrodt, A.W. J. Mol. Histol. (2004) [Pubmed]
  11. Zinc protects renal function during cadmium intoxication in the rat. Jacquillet, G., Barbier, O., Cougnon, M., Tauc, M., Namorado, M.C., Martin, D., Reyes, J.L., Poujeol, P. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  12. Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats. Kuribayashi, M., Wang, J., Fujiwara, O., Doi, Y., Nabae, K., Tamano, S., Ogiso, T., Asamoto, M., Shirai, T. Bioelectromagnetics. (2005) [Pubmed]
  13. Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Barber, A.J., Antonetti, D.A. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
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