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MeSH Review

Blood-Nerve Barrier

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Disease relevance of Blood-Nerve Barrier


High impact information on Blood-Nerve Barrier


Chemical compound and disease context of Blood-Nerve Barrier


Biological context of Blood-Nerve Barrier


Anatomical context of Blood-Nerve Barrier


Associations of Blood-Nerve Barrier with chemical compounds

  • Nerve water content and the permeability-surface area product (PA) to [3H]-or [14C]sucrose at the blood-nerve barrier were determined in unanesthetized control rats fed a normal diet and in rats fed galactose with or without an aldose reductase inhibitor (Statil or AL 1576) or a thromboxane synthetase inhibitor (CGS 12970) [2].
  • In galactosemic rats, the mean PA to sucrose at the blood-nerve barrier, calculated from nerve dry weight, was twofold higher than in control rats [2].
  • The mechanism of transfer of glucose across the blood-nerve barrier is unclarified [18].
  • To study the blood-nerve barrier, fluorescein isothiocyanate-labelled albumin was given intravenously after intraneural injection [19].
  • CONCLUSION: A breakdown in the blood-nerve barrier as observed on gadolinium-enhanced MR serves as a marker for nerve root pathology in the unoperated lumbosacral spine, which may have clinical relevance in certain clinical situations [20].

Gene context of Blood-Nerve Barrier


  1. Paraproteinaemic neuropathies. Steck, A.J., Erne, B., Gabriel, J.M., Schaeren-Wiemers, N. Brain Pathol. (1999) [Pubmed]
  2. Prevention of nerve edema and increased blood-nerve barrier permeability-surface area product in galactosemic rats by aldose reductase or thromboxane synthetase inhibitors. Wadhwani, K.C., Caspers-Velu, L.E., Murphy, V.A., Smith, Q.R., Kador, P.F., Rapoport, S.I. Diabetes (1989) [Pubmed]
  3. Reduced thrombomodulin in human peripheral nerve microvasculature. Hafer-Macko, C.E., Ivey, F.M., Gyure, K.A., Sorkin, J.D., Macko, R.F. Muscle Nerve (2002) [Pubmed]
  4. A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Baumgartner, S., Littleton, J.T., Broadie, K., Bhat, M.A., Harbecke, R., Lengyel, J.A., Chiquet-Ehrismann, R., Prokop, A., Bellen, H.J. Cell (1996) [Pubmed]
  5. Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. Auld, V.J., Fetter, R.D., Broadie, K., Goodman, C.S. Cell (1995) [Pubmed]
  6. Passive transfer of demyelination by serum or IgG from chronic inflammatory demyelinating polyneuropathy patients. Yan, W.X., Taylor, J., Andrias-Kauba, S., Pollard, J.D. Ann. Neurol. (2000) [Pubmed]
  7. Activated T cells of nonneural specificity open the blood-nerve barrier to circulating antibody. Pollard, J.D., Westland, K.W., Harvey, G.K., Jung, S., Bonner, J., Spies, J.M., Toyka, K.V., Hartung, H.P. Ann. Neurol. (1995) [Pubmed]
  8. Matrix metalloproteinase expression during experimental autoimmune neuritis. Hughes, P.M., Wells, G.M., Clements, J.M., Gearing, A.J., Redford, E.J., Davies, M., Smith, K.J., Hughes, R.A., Brown, M.C., Miller, K.M. Brain (1998) [Pubmed]
  9. In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: effect of ischemia and intrathecal hyperbaric 5% lidocaine. Benveniste, H., Qui, H., Hedlund, L.W., Hüttemeier, P.C., Steele, S.M., Johnson, G.A. Regional anesthesia and pain medicine. (1999) [Pubmed]
  10. FK506 promotes functional recovery in crushed rat sciatic nerve. Lee, M., Doolabh, V.B., Mackinnon, S.E., Jost, S. Muscle Nerve (2000) [Pubmed]
  11. Developmental and lesion-induced changes in the distribution of the glucose transporter Glut-1 in the central and peripheral nervous system. Stark, B., Carlstedt, T., Cullheim, S., Risling, M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2000) [Pubmed]
  12. Comparison of nerve regeneration in vascularized and conventional grafts: nerve electrophysiology, norepinephrine, prostacyclin, malondialdehyde, and the blood-nerve barrier. Shupeck, M., Ward, K.K., Schmelzer, J.D., Low, P.A. Brain Res. (1989) [Pubmed]
  13. Macrophage apolipoprotein synthesis and endoneurial distribution as a response to segmental demyelination. Gelman, B.B., Goodrum, J., Bouldin, T.W. J. Neuropathol. Exp. Neurol. (1991) [Pubmed]
  14. Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus. Rechthand, E., Smith, Q.R., Latker, C.H., Rapoport, S.I. J. Neuropathol. Exp. Neurol. (1987) [Pubmed]
  15. Cell-specific localization of glucose transporter proteins in mammalian lung. Devaskar, S.U., deMello, D.E. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  16. Hematopoietic cell transplantation after administration of high-dose busulfan in murine globoid cell leukodystrophy (the twitcher mouse). Yeager, A.M., Shinohara, M., Shinn, C. Pediatr. Res. (1991) [Pubmed]
  17. P-glycoprotein expression in capillary endothelial cells of the 7th and 8th nerves of guinea pig in relation to blood-nerve barrier sites. Saito, T., Zhang, Z.J., Shibamori, Y., Ohtsubo, T., Noda, I., Yamamoto, T., Saito, H. Neurosci. Lett. (1997) [Pubmed]
  18. Facilitated transport of glucose from blood into peripheral nerve. Rechthand, E., Smith, Q.R., Rapoport, S.I. J. Neurochem. (1985) [Pubmed]
  19. Effect of rhTNF-alpha injection into rat sciatic nerve. Uncini, A., Di Muzio, A., Di Guglielmo, G., De Angelis, M.V., De Luca, G., Lugaresi, A., Gambi, D. J. Neuroimmunol. (1999) [Pubmed]
  20. MR of enhancing nerve roots in the unoperated lumbosacral spine. Jinkins, J.R. AJNR. American journal of neuroradiology. (1993) [Pubmed]
  21. Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Poduslo, J.F., Curran, G.L. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  22. Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila. Banerjee, S., Pillai, A.M., Paik, R., Li, J., Bhat, M.A. J. Neurosci. (2006) [Pubmed]
  23. Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila. Schulte, J., Tepass, U., Auld, V.J. J. Cell Biol. (2003) [Pubmed]
  24. Loss and recovery of the blood-nerve barrier in the rat sciatic nerve after crush injury are associated with expression of intercellular junctional proteins. Hirakawa, H., Okajima, S., Nagaoka, T., Takamatsu, T., Oyamada, M. Exp. Cell Res. (2003) [Pubmed]
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