- Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. Aoyama, T., Okamoto, T., Nagayama, S., Nishijo, K., Ishibe, T., Yasura, K., Nakayama, T., Nakamura, T., Toguchida, J. J. Biol. Chem. (2004)