- Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Tissot van Patot, M.C., Bendrick-Peart, J., Beckey, V.E., Serkova, N., Zwerdlinger, L. Am. J. Physiol. Lung Cell Mol. Physiol. (2004)