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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells.

Munc-18-interacting (Mint) proteins are adaptors involved in regulation of synaptic vesicle exocytosis. We have investigated expression and cellular localization of Mint1 in pancreatic islets with special reference to insulin-secreting beta-cells. Western blotting showed that Mint1 was expressed in hamster (HIT-T15) and rat (RINm5F) beta-cell lines. Mint1 immunoreactivity was preferentially localized to the periphery of individual islet cells. RT-PCR analysis revealed that apart from Mint1, RINm5F cells and rat islets also transcribed the mRNAs for Mint2 and Mint3. Expression of Mint proteins in pancreatic beta-cells suggests a functional role for these proteins in insulin granule exocytosis.[1]


  1. Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells. Zhang, W., Lilja, L., Bark, C., Berggren, P.O., Meister, B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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