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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Apba1  -  amyloid beta (A4) precursor protein...

Rattus norvegicus

Synonyms: Adapter protein X11alpha, Amyloid beta A4 precursor protein-binding family A member 1, Mint-1, Mint1, Neuron-specific X11 protein, ...
 
 
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Disease relevance of Apba1

 

High impact information on Apba1

  • The three proteins are: (1) CASK, a protein related to MAGUKs (membrane-associated guanylate kinases); (2) Mint1, a putative vesicular trafficking protein; and (3) Veli1, -2, and -3, vertebrate homologs of C. elegans LIN-7 [2].
  • In a series of biochemical experiments, we demonstrate a specific association of the cytosolic carboxyl terminus of the N-type Ca(2+) channel pore-forming alpha(1B) subunit with the modular adaptor proteins Mint1 and CASK [3].
  • We propose that Munc-18 represents a dynamic link between syntaxin-related and Mint1-related mechanisms, both involved in the control of LDCV exocytosis in neuroendocrine cells [4].
  • Expression of Mint proteins in pancreatic beta-cells suggests a functional role for these proteins in insulin granule exocytosis [5].
  • We have investigated expression and cellular localization of Mint1 in pancreatic islets with special reference to insulin-secreting beta-cells [5].
 

Chemical compound and disease context of Apba1

 

Biological context of Apba1

 

Anatomical context of Apba1

  • In contrast, animals from seizure-free period (silent group) and during spontaneous seizures phase (chronic group) showed increased Mint1 immunostaining in all hippocampal subfields, mainly in the dentate gyrus, when compared to the control group [1].
 

Other interactions of Apba1

  • Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells [5].
  • RT-PCR analysis revealed that apart from Mint1, RINm5F cells and rat islets also transcribed the mRNAs for Mint2 and Mint3 [5].
 

Analytical, diagnostic and therapeutic context of Apba1

References

  1. Levels of the synaptic protein X11 alpha/mint1 are increased in hippocampus of rats with epilepsy. Scorza, C.A., Garrido, Y.d.e.l. .C., Arida, R.M., Amado, D., Cavalheiro, E.A., Naffah-Mazzacoratti, M.d.a. .G. Epilepsy Res. (2003) [Pubmed]
  2. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Butz, S., Okamoto, M., Südhof, T.C. Cell (1998) [Pubmed]
  3. Association of neuronal calcium channels with modular adaptor proteins. Maximov, A., Südhof, T.C., Bezprozvanny, I. J. Biol. Chem. (1999) [Pubmed]
  4. A dual function for Munc-18 in exocytosis of PC12 cells. Schütz, D., Zilly, F., Lang, T., Jahn, R., Bruns, D. Eur. J. Neurosci. (2005) [Pubmed]
  5. Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells. Zhang, W., Lilja, L., Bark, C., Berggren, P.O., Meister, B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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