- Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. Xiao, H.D., Fuchs, S., Campbell, D.J., Lewis, W., Dudley, S.C., Kasi, V.S., Hoit, B.D., Keshelava, G., Zhao, H., Capecchi, M.R., Bernstein, K.E. Am. J. Pathol. (2004)