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Gene Review

Vent1  -  ventricular size 1

Mus musculus

Synonyms: Vent8a
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Disease relevance of Vent1

  • We show that Vent DNA polymerase produces correct, blunt-ended primer extension products with substantially higher efficiency than Thermus aquaticus (Taq) DNA polymerase or modified T7 DNA polymerase (Sequenase) [1].
  • The present and previous studies suggest that subarachnoid fibrosis is an important factor in the disturbance of the spatial learning ability of rats, whereas ventricular size is less important [2].

High impact information on Vent1


Biological context of Vent1


Anatomical context of Vent1


Associations of Vent1 with chemical compounds

  • Qualitative analysis of ventricular size was performed on sections cut in the coronal plane of embryos at the 15th (E15) and 18th (E18) embryonic days, and postnatal mice aged 4 days (P4) [9].

Other interactions of Vent1

  • At this time of development, aberrant behaviors that mimic certain symptoms of schizophrenia also appeared in ckr mice suggesting that structural changes in ventricular size predates the onset of psychotic-like behaviors [10].

Analytical, diagnostic and therapeutic context of Vent1


  1. Effects of different DNA polymerases in ligation-mediated PCR: enhanced genomic sequencing and in vivo footprinting. Garrity, P.A., Wold, B.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Disturbed spatial learning of rats after intraventricular administration of transforming growth factor-beta 1. Nakazato, F., Tada, T., Sekiguchi, Y., Murakami, K., Yanagisawa, S., Tanaka, Y., Hongo, K. Neurol. Med. Chir. (Tokyo) (2002) [Pubmed]
  3. Noninvasive, in utero imaging of mouse embryonic heart development with 40-MHz echocardiography. Srinivasan, S., Baldwin, H.S., Aristizabal, O., Kwee, L., Labow, M., Artman, M., Turnbull, D.H. Circulation (1998) [Pubmed]
  4. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. Bloch, O., Auguste, K.I., Manley, G.T., Verkman, A.S. J. Cereb. Blood Flow Metab. (2006) [Pubmed]
  5. Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size. Popović, Z.B., Sun, J.P., Yamada, H., Drinko, J., Mauer, K., Greenberg, N.L., Cheng, Y., Moravec, C.S., Penn, M.S., Mazgalev, T.N., Thomas, J.D. J. Physiol. (Lond.) (2005) [Pubmed]
  6. Quantitative trait loci modulate ventricular size in the mouse brain. Zygourakis, C.C., Rosen, G.D. J. Comp. Neurol. (2003) [Pubmed]
  7. Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Cheng, Z., Lin, C., Hwang, T., Teng, C. Biochem. Pharmacol. (2001) [Pubmed]
  8. Nitric oxide synthase 2 and pressure-overload-induced left ventricular remodelling in mice. Hataishi, R., Rodrigues, A.C., Morgan, J.G., Ichinose, F., Derumeaux, G., Bloch, K.D., Picard, M.H., Scherrer-Crosbie, M. Exp. Physiol. (2006) [Pubmed]
  9. Chronologic changes of cerebral ventricular size in a transgenic model of hydrocephalus. Hayashi, N., Leifer, D.W., Cohen, A.R. Pediatric neurosurgery. (2000) [Pubmed]
  10. Ventricular size mapping in a transgenic model of schizophrenia. Torres, G., Meeder, B.A., Hallas, B.H., Spernyak, J.A., Mazurchuk, R., Jones, C., Gross, K.W., Horowitz, J.M. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  11. Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. Xiao, H.D., Fuchs, S., Campbell, D.J., Lewis, W., Dudley, S.C., Kasi, V.S., Hoit, B.D., Keshelava, G., Zhao, H., Capecchi, M.R., Bernstein, K.E. Am. J. Pathol. (2004) [Pubmed]
  12. Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Kohane, D.S., Plesnila, N., Thomas, S.S., Le, D., Langer, R., Moskowitz, M.A. Brain Res. (2002) [Pubmed]
  13. Nitrogen-13 ammonia cardiac positron emission tomography in mice: effects of clonidine-induced changes in cardiac work on myocardial perfusion. Inubushi, M., Jordan, M.C., Roos, K.P., Ross, R.S., Chatziioannou, A.F., Stout, D.B., Dahlbom, M., Schelbert, H.R. Eur. J. Nucl. Med. Mol. Imaging (2004) [Pubmed]
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