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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Dietary alpha-tocopherol affects differential gene expression in rat testes.

Gene-chip technology was employed to study the effect of dietary vitamin E (VE) on gene expression in rat testes. Male albino rats were fed with either a diet deficient in VE or a standard diet containing VE. Differential gene expression was monitored at five individual time-points over a period of 14 months with all animals individually profiled. Low VE intake resulted in the consistent up-regulation of 7-dehydrocholesterol reductase and GATA binding protein 4, both involved in testosterone synthesis. Cyclin D3, important in cell cycle progression and Wilms tumor 1, related to cancer development, were also up-regulated in the vitamin E deficient animals. This study demonstrates that low dietary VE intake has long-term effects on gene expression in the testes. Our data provides insights into the possible molecular mechanisms underlying the beneficial effects of vitamin E on the male reproductive organ.[1]


  1. Dietary alpha-tocopherol affects differential gene expression in rat testes. Rota, C., Barella, L., Minihane, A.M., Stöcklin, E., Rimbach, G. IUBMB Life (2004) [Pubmed]
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