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Gene Review

Gata4  -  GATA binding protein 4

Rattus norvegicus

Synonyms: DNA-binding protein GATA-GT2, GATA-binding factor 4, Transcription factor GATA-4
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Disease relevance of Gata4


High impact information on Gata4


Associations of Gata4 with chemical compounds


Analytical, diagnostic and therapeutic context of Gata4

  • Analysis of these sites, using electrophoretic mobility shift assays, revealed that Gata4 and another unknown factor bound within these regions [6].


  1. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. Pikkarainen, S., Tokola, H., Majalahti-Palviainen, T., Kerkela, R., Hautala, N., Bhalla, S.S., Charron, F., Nemer, M., Vuolteenaho, O., Ruskoaho, H. J. Biol. Chem. (2003) [Pubmed]
  2. Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart. Tenhunen, O., Sármán, B., Kerkelä, R., Szokodi, I., Papp, L., Tóth, M., Ruskoaho, H. J. Biol. Chem. (2004) [Pubmed]
  3. Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells. Tremblay, J.J., Viger, R.S. J. Biol. Chem. (2003) [Pubmed]
  4. Dietary alpha-tocopherol affects differential gene expression in rat testes. Rota, C., Barella, L., Minihane, A.M., Stöcklin, E., Rimbach, G. IUBMB Life (2004) [Pubmed]
  5. Pressure overload increases GATA4 binding activity via endothelin-1. Hautala, N., Tokola, H., Luodonpää, M., Puhakka, J., Romppanen, H., Vuolteenaho, O., Ruskoaho, H. Circulation (2001) [Pubmed]
  6. Gata4 regulates testis expression of Dmrt1. Lei, N., Heckert, L.L. Mol. Cell. Biol. (2004) [Pubmed]
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