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Gene Review

Dhcr7  -  7-dehydrocholesterol reductase

Rattus norvegicus

Synonyms: 7-DHC reductase, Sterol Delta(7)-reductase
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Disease relevance of Dhcr7

  • In this paper, we also observed liver cell-specific sterol-mediated Dhcr7 gene induction in vitro by sterol depletion in rat hepatoma cells, suggesting the presence of sterol-mediated regulatory elements in the Dhcr7 gene [1].
  • The cDNA encoding the 471-amino acid rat 7-dehydrocholesterol reductase (DHCR), an enzyme that has been implicated in both cholesterol biosynthesis and developmental abnormalities (e.g. Smith-Lemli-Opitz syndrome) in mammals, has been cloned and sequenced, and the primary structure of the enzyme has been deduced [2].
  • In previous studies, early administration of the 7DHC-reductase inhibitor AY9944 to pregnant rats resulted in a high frequency of holoprosencephaly, relevant to craniofacial anomalies of SLOS [3].

Psychiatry related information on Dhcr7


High impact information on Dhcr7


Biological context of Dhcr7

  • Interestingly, human Dhcr7 gene in HepG2 cells produced no detectable isoform while mouse Dhcr7 gene in L929 cells produced three isoforms, suggesting a difference in alternative splicing between species [6].
  • Unexpectedly, we have found the occurrence of at least five isoforms of Dhcr7, designated as Dhcr7-AS (alternatively spliced)-1 (1474 nts), -2 (1595 nts), -3 (1602 nts), -4 (1723 nts) and -5 (1287 nts), which was believed to be caused by alternative usage of three 5' noncoding exons [6].
  • We previously reported that the Dhcr7 proximal promoter (-179 to +1), which contains CpG islands, is responsible for sterol-mediated expression of the rat gene [7].
  • In the present study, we examined whether methylation of this region affects the transcriptional activity of the Dhcr7 gene [7].
  • In vitro DNA methylation of the Dhcr7 promoter and luciferase-reporter assays showed that DNA methylation of the CpG islands suppressed transcription [7].

Anatomical context of Dhcr7


Associations of Dhcr7 with chemical compounds


Other interactions of Dhcr7


  1. Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression. Kim, J.H., Lee, J.N., Paik, Y.K. J. Biol. Chem. (2001) [Pubmed]
  2. Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. Bae, S.H., Lee, J.N., Fitzky, B.U., Seong, J., Paik, Y.K. J. Biol. Chem. (1999) [Pubmed]
  3. Abnormal cholesterol biosynthesis as in Smith-Lemli-Opitz syndrome disrupts normal skeletal development in the rat. Kolf-Clauw, M., Chevy, F., Ponsart, C. J. Lab. Clin. Med. (1998) [Pubmed]
  4. Smith-Lemli-Opitz syndrome: the first malformation syndrome associated with defective cholesterol synthesis. Battaile, K.P., Steiner, R.D. Mol. Genet. Metab. (2000) [Pubmed]
  5. DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis. Anbalagan, M., Yashwanth, R., Jagannadha Rao, A. Mol. Cell. Endocrinol. (2004) [Pubmed]
  6. Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene. Lee, J.N., Bae, S.H., Paik, Y.K. Biochim. Biophys. Acta (2002) [Pubmed]
  7. Methylation of CpG islands in the rat 7-dehydrocholesterol reductase promoter suppresses transcriptional activation. Kim, J.H., Hwang, E.H., Park, H.J., Paik, Y.K., Shim, Y.H. Mol. Cells (2005) [Pubmed]
  8. The role of sterol carrier protein 2 in stimulation of steroidogenesis in rat adrenal mitochondria by adrenal cytosol. McNamara, B.C., Jefcoate, C.R. Arch. Biochem. Biophys. (1989) [Pubmed]
  9. Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome. Gofflot, F., Kolf-Clauw, M., Clotman, F., Roux, C., Picard, J.J. Am. J. Med. Genet. (1999) [Pubmed]
  10. Dietary alpha-tocopherol affects differential gene expression in rat testes. Rota, C., Barella, L., Minihane, A.M., Stöcklin, E., Rimbach, G. IUBMB Life (2004) [Pubmed]
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