- Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor but does not depend on endothelial NO synthase. Kilic, E., Kilic, U., Matter, C.M., Lüscher, T.F., Bassetti, C.L., Hermann, D.M. Stroke (2005)