Gene Review:
Plg - plasminogen
Mus musculus
Synonyms:
AI649309, Pg, Plasminogen
Lijnen,
Shipley,
Arcaroli,
Senior,
Liu,
Stoop,
Green,
Gukovskaya,
Craik,
Nielsen,
Diaz,
French,
Pandol,
Werb,
Lemmens,
Gyetko,
Strassheim,
Frederix,
Almholt,
Nan,
Danø,
Kuhn,
Lund,
Berk,
Abraham,
Idell,
Collen,
Bezerra,
Day,
Katar,
Silence,
Park,
Ploug,
Shetty,
Rømer,
Lilla,
Christensen,
Dong,
Werb,
Li,
Lugea,
- Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Bugge, T.H., Flick, M.J., Daugherty, C.C., Degen, J.L. Genes Dev. (1995)
- Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. Liu, Z., Li, N., Diaz, L.A., Shipley, M., Senior, R.M., Werb, Z. J. Clin. Invest. (2005)
- Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice. Lugea, A., Nan, L., French, S.W., Bezerra, J.A., Gukovskaya, A.S., Pandol, S.J. Gastroenterology (2006)
- Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Ploplis, V.A., Carmeliet, P., Vazirzadeh, S., Van Vlaenderen, I., Moons, L., Plow, E.F., Collen, D. Circulation (1995)
- Drug dependence, synaptic plasticity, and tissue plasminogen activator. Yamada, K., Nagai, T., Nabeshima, T. J. Pharmacol. Sci. (2005)
- Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Dong, Z., Kumar, R., Yang, X., Fidler, I.J. Cell (1997)
- Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice. Coleman, J.L., Gebbia, J.A., Piesman, J., Degen, J.L., Bugge, T.H., Benach, J.L. Cell (1997)
- Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. Bugge, T.H., Kombrinck, K.W., Flick, M.J., Daugherty, C.C., Danton, M.J., Degen, J.L. Cell (1996)
- Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA. Sharon, R., Abramovitz, R., Miskin, R. Brain Res. Mol. Brain Res. (2002)
- The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system. Swaisgood, C.M., French, E.L., Noga, C., Simon, R.H., Ploplis, V.A. Am. J. Pathol. (2000)
- Plasminogen activators promote excitotoxicity-induced retinal damage. Mali, R.S., Cheng, M., Chintala, S.K. FASEB J. (2005)
- Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging. Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D.J., Saito, H. Am. J. Pathol. (2002)
- NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. Nishikawa, M., Stapleton, P.P., Freeman, T.A., Gaughan, J.P., Matsuda, T., Daly, J.M. J. Am. Coll. Surg. (2004)
- Reduced transplant arteriosclerosis in plasminogen-deficient mice. Moons, L., Shi, C., Ploplis, V., Plow, E., Haber, E., Collen, D., Carmeliet, P. J. Clin. Invest. (1998)
- The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice. Cheng, Q., Zhao, Y., Lawson, W.E., Polosukhin, V.V., Johnson, J.E., Blackwell, T.S., Gailani, D. Blood (2005)
- Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo. Suelves, M., López-Alemany, R., Lluís, F., Aniorte, G., Serrano, E., Parra, M., Carmeliet, P., Muñoz-Cánoves, P. Blood (2002)
- Regulation of gelatinase activity in mice with targeted inactivation of components of the plasminogen/plasmin system. Lijnen, H.R., Silence, J., Lemmens, G., Frederix, L., Collen, D. Thromb. Haemost. (1998)
- Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. Lund, L.R., Green, K.A., Stoop, A.A., Ploug, M., Almholt, K., Lilla, J., Nielsen, B.S., Christensen, I.J., Craik, C.S., Werb, Z., Danø, K., Rømer, J. EMBO J. (2006)
- Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus. Pawlak, R., Rao, B.S., Melchor, J.P., Chattarji, S., McEwen, B., Strickland, S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Plasminogen Activator Inhibitor Type-1-Deficient Mice Have an Enhanced IFN-{gamma} Response to Lipopolysaccharide and Staphylococcal Enterotoxin B. Renckens, R., Pater, J.M., Poll, T. J. Immunol. (2006)
- A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. Heinemann, F.S., Korza, G., Ozols, J. J. Biol. Chem. (2003)
- Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice. Wahlberg, P., Bodén, I., Paulsson, J., Lund, L.R., Liu, K., Ny, T. Endocrinology (2007)
- Genetic polymorphism of murine tissue plasminogen activator associated with antiphospholipid syndrome. Shirai, J., Ida, A., Jiang, Y., Sanokawa-Akakura, R., Miura, Y., Yan, K., Hamano, Y., Hirose, S., Shirai, T. Genes Immun. (1999)
- Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). Lee, C.G., Homer, R.J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J.M., Gotwals, P., Noble, P., Chen, Q., Senior, R.M., Elias, J.A. J. Exp. Med. (2001)
- Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation. Tarui, T., Akakura, N., Majumdar, M., Andronicos, N., Takagi, J., Mazar, A.P., Bdeir, K., Kuo, A., Yarovoi, S.V., Cines, D.B., Takada, Y. Thromb. Haemost. (2006)
- Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice. Mueller, B.M., Yu, Y.B., Laug, W.E. Proc. Natl. Acad. Sci. U.S.A. (1995)
- The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin. Osterwalder, T., Cinelli, P., Baici, A., Pennella, A., Krueger, S.R., Schrimpf, S.P., Meins, M., Sonderegger, P. J. Biol. Chem. (1998)
- Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation. Abraham, E., Gyetko, M.R., Kuhn, K., Arcaroli, J., Strassheim, D., Park, J.S., Shetty, S., Idell, S. J. Immunol. (2003)
- Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain. Stack, M.S., Gray, R.D., Pizzo, S.V. Cancer Res. (1993)
- Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen. Lijnen, H.R., Carmeliet, P., Bouché, A., Moons, L., Ploplis, V.A., Plow, E.F., Collen, D. Blood (1996)
- Plasminogen directs the pleiotropic effects of uPA in liver injury and repair. Currier, A.R., Sabla, G., Locaputo, S., Melin-Aldana, H., Degen, J.L., Bezerra, J.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Plasminogen/plasmin regulates alpha-enolase expression through the MEK/ERK pathway. Sousa, L.P., Silva, B.M., Brasil, B.S., Nogueira, S.V., Ferreira, P.C., Kroon, E.G., Kato, K., Bonjardim, C.A. Biochem. Biophys. Res. Commun. (2005)
- Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species. Min, K.J., Jou, I., Joe, E. Biochem. Biophys. Res. Commun. (2003)
- The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. Bajou, K., Masson, V., Gerard, R.D., Schmitt, P.M., Albert, V., Praus, M., Lund, L.R., Frandsen, T.L., Brunner, N., Dano, K., Fusenig, N.E., Weidle, U., Carmeliet, G., Loskutoff, D., Collen, D., Carmeliet, P., Foidart, J.M., Noël, A. J. Cell Biol. (2001)
- Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression. Bolon, I., Zhou, H.M., Charron, Y., Wohlwend, A., Vassalli, J.D. Am. J. Pathol. (2004)
- Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein. Jones, A.L., Hulett, M.D., Altin, J.G., Hogg, P., Parish, C.R. J. Biol. Chem. (2004)
- Plasminogen Activators and Inhibitors in the Corneas of Mice Infected with Pseudomonas aeruginosa. Berk, R.S., Katar, M., Dong, Z., Day, D.E. Invest. Ophthalmol. Vis. Sci. (2001)
- Matrix metalloproteinase deficiencies do not impair cell-associated fibrinolytic activity. Ugwu, F., Lemmens, G., Collen, D., Lijnen, H.R. Thromb. Res. (2001)