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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Experimental calcification of HEMA-based hydrogels in the presence of albumin and a comparison to the in vivo calcification.

The precipitation patterns and characteristics of calcium phosphate (CaP) phases deposited on HEMA-based hydrogels upon incubation in simulated body fluid (SBF-2) containing a protein (human serum albumin) have been investigated in relation to the calcification in an organic-free medium (SBF-1) and to that occurring after subcutaneous implantation in rats. In SBF-2, the deposits occurred exclusively as a peripheral layer on the surface of the hydrogels and consisted mainly of "precipitated hydroxyapatite", a species deficient in calcium and hydroxyl ions, similarly to the deposits formed on the implanted hydrogels, where the deposited layer was thicker. In SBF-1, the deposits were mainly of brushite type. There was no evidence that albumin penetrated the interstices of hydrogels. As the X-ray diffraction patterns of the CaP deposits generated in SBF-2 showed a similar nature with those formed on the implanted hydrogel, it was concluded that the calcification in SBF-2 can mimic to a reliable extent the calcification process taking place in a biological environment.[1]

References

  1. Experimental calcification of HEMA-based hydrogels in the presence of albumin and a comparison to the in vivo calcification. Zainuddin, Z., Hill, D.J., Chirila, T.V., Whittaker, A.K., Kemp, A. Biomacromolecules (2006) [Pubmed]
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