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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas.

Tyr-3-Octreotide is a synthetic derivative of somatostatin and a somatostatin-receptor analogue. The iodine-123-labelled compound localizes somatostatin-receptor-positive tumours. In this paper two patients are reported in whom somatostatin receptors were demonstrated in vitro. In a 60-year-old female with an islet cell carcinoma of the pancreas, multiple liver metastases and previously unrecognized bone metastases in the right acetabulum could be diagnosed as the reason for a persistent hypoglycaemia. In a 60-year-old male an islet cell carcinoma of the pancreas was localized with 123I-Tyr-3-octreotide. The somatostatin receptors were demonstrated in vitro and the tumour was successfully treated with somatostatin. These studies demonstrate that 123I-Tyr-3-octreotide offers the possibility of localizing somatostatin-receptor-positive tumours and their metastases. Moreover the method makes it possible to determine the receptor status of a tumour in vivo.[1]

References

  1. Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas. Becker, W., Marienhagen, J., Scheubel, R., Saptogino, A., Bakker, W.H., Breeman, W.A., Wolf, F. European journal of nuclear medicine. (1991) [Pubmed]
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