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Chemical Compound Review:

Tyr(3)-sms 10-(4-aminobutyl)-19-[(2- amino-3-phenyl...

Synonyms: AC1L3XFS, Sdz-204-090, Sms-204-090, AR-1B9971, Sdz 204-090, ...

Krenning, E.P. et al., Faglia, G. et al., Pantev, T. et al., Bomanji, J. et al., Mackie, E.J. et al., et al.

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Disease relevance of Tyr-3-octreotide

We compared an 123I-labeled somatostatin analog Tyr-3-octreotide (TOCT) and 123I-labeled metaiodobenzylguanidine (MIBG) scintigraphy in seven patients with histologically proven metastatic carcinoid tumors [1].

High impact information on Tyr-3-octreotide

Thus radioiodinated tyr-3-octreotide can label somatostatin receptors in endocrine-related tumours in vivo and can therefore be used for tumour localisation [2].
In the present study, the distribution of somatostatin receptors during embryonic bone formation has been investigated using the stable radioiodinated somatostatin analogue, SDZ 204-090 [3].
Tyr-3-Octreotide is a synthetic derivative of somatostatin and a somatostatin-receptor analogue [4].
The ontogeny of somatostatin receptor binding was studied in developing rat retina using the iodinated derivative of the somatostatin analog, SMS 204-090 [5].
The IC50 values (2.5-112 nM versus 0.02-69 nM) were different for the octreotide and Tyr-3-octreotide indicating that octreotide was the better competitor as Tyr-3-octreotide for 123I-Tyr-3-octreotide binding sites [6].

Anatomical context of Tyr-3-octreotide

The somatostatin receptors on rat pancreatic acinar membranes were demonstrated by use of a radioiodinated (125I-) analogue of somatostatin (SMS 204-090 or [Tyr3]SMS) [7].

Associations of Tyr-3-octreotide with other chemical compounds

The recent availability of a Tyr3-substituted octreotide (SDZ 204-090) for radioiodination has allowed somatostatin (SRIH) receptor binding to be studied in vivo, and receptor-positive tumors of different origins to be visualized with a gamma-camera [8].

Analytical, diagnostic and therapeutic context of Tyr-3-octreotide

123I-labelled tyr-3-octreotide (tyr-3-SMS 201-995, a synthetic derivative of somatostatin) was used to localise such tumours in vivo with a gamma-camera [2].

References

A scintigraphic comparison of iodine-123-metaiodobenzylguanidine and an iodine-labeled somatostatin analog (Tyr-3-octreotide) in metastatic carcinoid tumors. Bomanji, J., Mather, S., Moyes, J., Ellison, D., Grossman, A., Britton, K.E., Besser, G.M. J. Nucl. Med. (1992) [Pubmed]
Localisation of endocrine-related tumours with radioiodinated analogue of somatostatin. Krenning, E.P., Bakker, W.H., Breeman, W.A., Koper, J.W., Kooij, P.P., Ausema, L., Lameris, J.S., Reubi, J.C., Lamberts, S.W. Lancet (1989) [Pubmed]
Somatostatin receptors are restricted to a subpopulation of osteoblast-like cells during endochondral bone formation. Mackie, E.J., Trechsel, U., Bruns, C. Development (1990) [Pubmed]
Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas. Becker, W., Marienhagen, J., Scheubel, R., Saptogino, A., Bakker, W.H., Breeman, W.A., Wolf, F. European journal of nuclear medicine. (1991) [Pubmed]
Developmental expression of somatostatin receptors in the rat retina. Ferriero, D.M. Brain Res. Dev. Brain Res. (1992) [Pubmed]
Evaluation of somatostatin receptors in human cancer. Pantev, T., Virgolini, I., Neuhold, N., Angelberger, P., Luger, A., Sinzinger, H. Wien. Klin. Wochenschr. (1991) [Pubmed]
Molecular characterization of the solubilized receptor of somatostatin from rat pancreatic acinar membranes. Knuhtsen, S., Esteve, J.P., Bernadet, B., Vaysse, N., Susini, C. Biochem. J. (1988) [Pubmed]
In vivo detection of somatostatin receptors in patients with functionless pituitary adenomas by means of a radioiodinated analog of somatostatin ([123I]SDZ 204-090). Faglia, G., Bazzoni, N., Spada, A., Arosio, M., Ambrosi, B., Spinelli, F., Sara, R., Bonino, C., Lunghi, F. J. Clin. Endocrinol. Metab. (1991) [Pubmed]

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