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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

MCT-1 Protein Interacts with the Cap Complex and Modulates Messenger RNA Translational Profiles.

MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we established that MCT-1 protein interacts with the cap complex through its PUA domain and recruits the density-regulated protein (DENR/ DRP), containing the SUI1 translation initiation domain. Through the use of microarray analysis on polysome-associated mRNAs, we showed that up-regulation of MCT-1 was able to modulate the translation profiles of BCL2L2, TFDP1, MRE11A, cyclin D1, and E2F1 mRNAs, despite equivalent levels of mRNAs in the cytoplasm. Our data establish a role for MCT-1 in translational regulation, and support a linkage between translational control and oncogenesis. (Cancer Res 2006; 66(18): 8994-9001).[1]

References

  1. MCT-1 Protein Interacts with the Cap Complex and Modulates Messenger RNA Translational Profiles. Reinert, L.S., Shi, B., Nandi, S., Mazan-Mamczarz, K., Vitolo, M., Bachman, K.E., He, H., Gartenhaus, R.B. Cancer Res. (2006) [Pubmed]
 
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