Gene Review:
MRE11A - MRE11 meiotic recombination 11 homolog A...
Homo sapiens
Synonyms:
ATLD, Double-strand break repair protein MRE11A, HNGS1, MRE11, MRE11 homolog 1, ...
- Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes. Allen-Brady, K., Camp, N.J. BMC Cancer (2005)
- The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Stewart, G.S., Maser, R.S., Stankovic, T., Bressan, D.A., Kaplan, M.I., Jaspers, N.G., Raams, A., Byrd, P.J., Petrini, J.H., Taylor, A.M. Cell (1999)
- Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder. Fernet, M., Gribaa, M., Salih, M.A., Seidahmed, M.Z., Hall, J., Koenig, M. Hum. Mol. Genet. (2005)
- Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks. Takemura, H., Rao, V.A., Sordet, O., Furuta, T., Miao, Z.H., Meng, L., Zhang, H., Pommier, Y. J. Biol. Chem. (2006)
- Human Cytomegalovirus Disrupts both Ataxia Telangiectasia Mutated Protein (ATM)- and ATM-Rad3-Related Kinase-Mediated DNA Damage Responses during Lytic Infection. Luo, M.H., Rosenke, K., Czornak, K., Fortunato, E.A. J. Virol. (2007)
- Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. Jacobsen, E., Beach, T., Shen, Y., Li, R., Chang, Y. Brain Res. Mol. Brain Res. (2004)
- The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Falck, J., Petrini, J.H., Williams, B.R., Lukas, J., Bartek, J. Nat. Genet. (2002)
- The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Lobachev, K.S., Gordenin, D.A., Resnick, M.A. Cell (2002)
- An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele. Maser, R.S., Zinkel, R., Petrini, J.H. Nat. Genet. (2001)
- Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Hopfner, K.P., Karcher, A., Craig, L., Woo, T.T., Carney, J.P., Tainer, J.A. Cell (2001)
- Inactivation of Mre11 does not affect VSG gene duplication mediated by homologous recombination in Trypanosoma brucei. Robinson, N.P., McCulloch, R., Conway, C., Browitt, A., Barry, J.D. J. Biol. Chem. (2002)
- Translocation of MRE11 from the nucleus to the cytoplasm as a mechanism of radiosensitization by heat. Zhu, W.G., Seno, J.D., Beck, B.D., Dynlacht, J.R. Radiat. Res. (2001)
- Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Zhu, X.D., Küster, B., Mann, M., Petrini, J.H., de Lange, T. Nat. Genet. (2000)
- ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. Stiff, T., Walker, S.A., Cerosaletti, K., Goodarzi, A.A., Petermann, E., Concannon, P., O'driscoll, M., Jeggo, P.A. EMBO J. (2006)
- Mre11 deficiency in Arabidopsis is associated with chromosomal instability in somatic cells and Spo11-dependent genome fragmentation during meiosis. Puizina, J., Siroky, J., Mokros, P., Schweizer, D., Riha, K. Plant Cell (2004)
- Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions. Chamankhah, M., Wei, Y.F., Xiao, W. Gene (1998)
- Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Giannini, G., Rinaldi, C., Ristori, E., Ambrosini, M.I., Cerignoli, F., Viel, A., Bidoli, E., Berni, S., D'Amati, G., Scambia, G., Frati, L., Screpanti, I., Gulino, A. Oncogene (2004)
- Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Goedecke, W., Eijpe, M., Offenberg, H.H., van Aalderen, M., Heyting, C. Nat. Genet. (1999)
- MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Larson, E.D., Cummings, W.J., Bednarski, D.W., Maizels, N. Mol. Cell (2005)
- Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks. Robison, J.G., Elliott, J., Dixon, K., Oakley, G.G. J. Biol. Chem. (2004)
- DNA damage foci at dysfunctional telomeres. Takai, H., Smogorzewska, A., de Lange, T. Curr. Biol. (2003)
- Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism. Yuan, S.S., Chang, H.L., Hou, M.F., Chan, T.F., Kao, Y.H., Wu, Y.C., Su, J.H. Toxicology (2002)
- Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells. Yuan, S.S., Su, J.H., Hou, M.F., Yang, F.W., Zhao, S., Lee, E.Y. DNA Repair (Amst.) (2002)
- Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Boisvert, F.M., Déry, U., Masson, J.Y., Richard, S. Genes Dev. (2005)
- The Mre11 complex is required for ATM activation and the G2/M checkpoint. Carson, C.T., Schwartz, R.A., Stracker, T.H., Lilley, C.E., Lee, D.V., Weitzman, M.D. EMBO J. (2003)
- Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. Cheng, W.H., von Kobbe, C., Opresko, P.L., Arthur, L.M., Komatsu, K., Seidman, M.M., Carney, J.P., Bohr, V.A. J. Biol. Chem. (2004)
- NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Kobayashi, J., Tauchi, H., Sakamoto, S., Nakamura, A., Morishima, K., Matsuura, S., Kobayashi, T., Tamai, K., Tanimoto, K., Komatsu, K. Curr. Biol. (2002)
- Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication? Pichierri, P., Franchitto, A. Bioessays (2004)
- Protein kinase CK2 interacts with Chk2 and phosphorylates Mre11 on serine 649. Kim, S.T. Biochem. Biophys. Res. Commun. (2005)
- MDC1 is required for the intra-S-phase DNA damage checkpoint. Goldberg, M., Stucki, M., Falck, J., D'Amours, D., Rahman, D., Pappin, D., Bartek, J., Jackson, S.P. Nature (2003)
- The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage. Dong, Z., Zhong, Q., Chen, P.L. J. Biol. Chem. (1999)
- MRE11/RAD50/NBS1: complex activities. Assenmacher, N., Hopfner, K.P. Chromosoma (2004)
- DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin. Limoli, C.L., Laposa, R., Cleaver, J.E. Mutat. Res. (2002)
- ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. Trenz, K., Smith, E., Smith, S., Costanzo, V. EMBO J. (2006)
- MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. Delia, D., Piane, M., Buscemi, G., Savio, C., Palmeri, S., Lulli, P., Carlessi, L., Fontanella, E., Chessa, L. Hum. Mol. Genet. (2004)
- MRE11 expression is impaired in gastric cancer with microsatellite instability. Ottini, L., Falchetti, M., Saieva, C., De Marco, M., Masala, G., Zanna, I., Paglierani, M., Giannini, G., Gulino, A., Nesi, G., Mariani Costantini, R., Palli, D. Carcinogenesis (2004)
- The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells. Li, L., Sharipo, A., Chaves-Olarte, E., Masucci, M.G., Levitsky, V., Thelestam, M., Frisan, T. Cell. Microbiol. (2002)
- Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1 degrees C and its effect on DNA repair. Xu, M., Myerson, R.J., Straube, W.L., Moros, E.G., Lagroye, I., Wang, L.L., Lee, J.T., Roti Roti, J.L. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (2002)