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Gene Review

EIF1  -  eukaryotic translation initiation factor 1

Homo sapiens

Synonyms: A121, EIF-1, EIF1A, Eukaryotic translation initiation factor 1, ISO1, ...
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Disease relevance of EIF1


Psychiatry related information on EIF1


High impact information on EIF1

  • Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA [7].
  • Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms [8].
  • Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing [9].
  • The cleavage of 18S rRNA in helices 23b, 24a, and 44 by hydroxyl radicals generated from Fe(II) tethered to seven positions on the surface of eIF1 places eIF1 on the interface surface of the platform of the 40S subunit in the proximity of the ribosomal P-site [9].
  • We also show that like IF3, eIF1 can influence initiator tRNA selection, which occurs at the stage of ribosomal subunit joining after eIF5-induced hydrolysis of eIF2-bound GTP [10].

Biological context of EIF1


Anatomical context of EIF1


Associations of EIF1 with chemical compounds


Physical interactions of EIF1


Enzymatic interactions of EIF1


Regulatory relationships of EIF1


Other interactions of EIF1


Analytical, diagnostic and therapeutic context of EIF1

  • While most clones represent individual genes sequence analysis revealed that four of the 17 cDNAs are nearly identical with the eukaryotic translation initiation factor (eIF)-4gamma recently assigned on 3q [29].
  • In a Western blot of A121 cell extracts separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, 125I-labeled polymerized galaptin bound [corrected] to a unique cellular protein having a molecular mass of 110 kDa [20].
  • In DU-145 xenografts, ISO-1 significantly decreased tumor volume and tumor angiogenesis [30].
  • The therapeutic importance of the MIF inhibition by ISO-1 is demonstrated by the significant protection from sepsis, induced by cecal ligation and puncture in a clinically relevant time frame [16].
  • The SH-1 melanoma, A549 lung adenocarcinoma, and A121 ovarian carcinoma xenografts responded well to the i.p. administration of analogue with obvious tumor regressions, long-term tumor growth suppressions, and a significant proportion (up to 40%) of apparent cures (i.e., lack of tumor regrowth) [31].


  1. The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis. Lian, Z., Pan, J., Liu, J., Zhang, S., Zhu, M., Arbuthnot, P., Kew, M., Feitelson, M.A. Oncogene (1999) [Pubmed]
  2. RNA helicase activity associated with the human p68 protein. Hirling, H., Scheffner, M., Restle, T., Stahl, H. Nature (1989) [Pubmed]
  3. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Gradi, A., Svitkin, Y.V., Imataka, H., Sonenberg, N. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. Davies, M.V., Furtado, M., Hershey, J.W., Thimmappaya, B., Kaufman, R.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Molecular mechanisms of translation initiation in eukaryotes. Pestova, T.V., Kolupaeva, V.G., Lomakin, I.B., Pilipenko, E.V., Shatsky, I.N., Agol, V.I., Hellen, C.U. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Double-stranded RNA-dependent protein kinase (PKR) is a stress-responsive kinase that induces NFkappaB-mediated resistance against mercury cytotoxicity. Frémont, M., Vaeyens, F., Herst, C.V., De Meirleir, K.L., Englebienne, P. Life Sci. (2006) [Pubmed]
  7. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Gingras, A.C., Raught, B., Sonenberg, N. Annu. Rev. Biochem. (1999) [Pubmed]
  8. Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Kahvejian, A., Svitkin, Y.V., Sukarieh, R., M'Boutchou, M.N., Sonenberg, N. Genes Dev. (2005) [Pubmed]
  9. Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. Lomakin, I.B., Kolupaeva, V.G., Marintchev, A., Wagner, G., Pestova, T.V. Genes Dev. (2003) [Pubmed]
  10. The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH. Lomakin, I.B., Shirokikh, N.E., Yusupov, M.M., Hellen, C.U., Pestova, T.V. EMBO J. (2006) [Pubmed]
  11. Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). Sheikh, M.S., Fernandez-Salas, E., Yu, M., Hussain, A., Dinman, J.D., Peltz, S.W., Huang, Y., Fornace, A.J. J. Biol. Chem. (1999) [Pubmed]
  12. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. Raught, B., Gingras, A.C., Gygi, S.P., Imataka, H., Morino, S., Gradi, A., Aebersold, R., Sonenberg, N. EMBO J. (2000) [Pubmed]
  13. Cleavage of eukaryotic translation initiation factor 4G by exogenously added hybrid proteins containing poliovirus 2Apro in HeLa cells: effects on gene expression. Novoa, I., Carrasco, L. Mol. Cell. Biol. (1999) [Pubmed]
  14. Human ovarian carcinoma beta-N-acetylglucosaminidase isoenzymes and their role in extracellular matrix degradation. Woynarowska, B., Wikiel, H., Bernacki, R.J. Cancer Res. (1989) [Pubmed]
  15. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells. Raught, B., Gingras, A.C., James, A., Medina, D., Sonenberg, N., Rosen, J.M. Cancer Res. (1996) [Pubmed]
  16. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. Al-Abed, Y., Dabideen, D., Aljabari, B., Valster, A., Messmer, D., Ochani, M., Tanovic, M., Ochani, K., Bacher, M., Nicoletti, F., Metz, C., Pavlov, V.A., Miller, E.J., Tracey, K.J. J. Biol. Chem. (2005) [Pubmed]
  17. Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Kazemi, S., Papadopoulou, S., Li, S., Su, Q., Wang, S., Yoshimura, A., Matlashewski, G., Dever, T.E., Koromilas, A.E. Mol. Cell. Biol. (2004) [Pubmed]
  18. 2-Aminopurine selectively inhibits splicing of tumor necrosis factor alpha mRNA. Jarrous, N., Osman, F., Kaempfer, R. Mol. Cell. Biol. (1996) [Pubmed]
  19. Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap. McKendrick, L., Thompson, E., Ferreira, J., Morley, S.J., Lewis, J.D. Mol. Cell. Biol. (2001) [Pubmed]
  20. Galaptin-mediated adhesion of human ovarian carcinoma A121 cells and detection of cellular galaptin-binding glycoproteins. Skrincosky, D.M., Allen, H.J., Bernacki, R.J. Cancer Res. (1993) [Pubmed]
  21. The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities. Park, M.H. J. Biol. Chem. (1989) [Pubmed]
  22. A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Yang, H.S., Cho, M.H., Zakowicz, H., Hegamyer, G., Sonenberg, N., Colburn, N.H. Mol. Cell. Biol. (2004) [Pubmed]
  23. Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation. Wakiyama, M., Imataka, H., Sonenberg, N. Curr. Biol. (2000) [Pubmed]
  24. The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2. Cassady, K.A., Gross, M., Roizman, B. J. Virol. (1998) [Pubmed]
  25. Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Kumar, K.U., Srivastava, S.P., Kaufman, R.J. Mol. Cell. Biol. (1999) [Pubmed]
  26. DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Levy-Strumpf, N., Deiss, L.P., Berissi, H., Kimchi, A. Mol. Cell. Biol. (1997) [Pubmed]
  27. Promyelocytic leukaemia-immunoreactive neuronal intranuclear rodlets in the human brain. Woulfe, J.M., Prichett-Pejic, W., Rippstein, P., Munoz, D.G. Neuropathol. Appl. Neurobiol. (2007) [Pubmed]
  28. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Brush, M.H., Weiser, D.C., Shenolikar, S. Mol. Cell. Biol. (2003) [Pubmed]
  29. Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma. Brass, N., Heckel, D., Sahin, U., Pfreundschuh, M., Sybrecht, G.W., Meese, E. Hum. Mol. Genet. (1997) [Pubmed]
  30. Inhibition of Macrophage Migration Inhibitory Factor or Its Receptor (CD74) Attenuates Growth and Invasion of DU-145 Prostate Cancer Cells. Meyer-Siegler, K.L., Iczkowski, K.A., Leng, L., Bucala, R., Vera, P.L. J. Immunol. (2006) [Pubmed]
  31. Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. Bernacki, R.J., Oberman, E.J., Seweryniak, K.E., Atwood, A., Bergeron, R.J., Porter, C.W. Clin. Cancer Res. (1995) [Pubmed]
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