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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor.

Lymphatic vessels develop from specialized venous endothelial cells. Using knockout mice, we found that fasting-induced adipose factor (Fiaf) is required for functional partitioning of postnatal intestinal lymphatic and blood vessels. In wild-type animals, levels of intestinal Fiaf expression rise during the first postnatal day and peak at day 2, which coincides with the onset of the lymphatico-venous partitioning abnormality in Fiaf-/- mutants on a mixed 129/SvJ:C57BL/6 genetic background. Fiaf deficiency is not associated with disruption of the blood vasculature or with lymphatic endothelial recruitment of smooth muscle cells. We identified Prox1, a critical regulator of lymphangiogenesis, as a downstream target for Fiaf signaling in the intestinal lymphatic endothelium. This organ-specific lymphovascular abnormality can be rescued by allowing embryonic Fiaf-/- intestinal isografts to develop in Fiaf+/+ recipients.[1]

References

  1. Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor. B??ckhed, F., Crawford, P.A., O'donnell, D., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
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