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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Lymphangiogenesis


High impact information on Lymphangiogenesis


Biological context of Lymphangiogenesis


Anatomical context of Lymphangiogenesis


Associations of Lymphangiogenesis with chemical compounds


Gene context of Lymphangiogenesis


Analytical, diagnostic and therapeutic context of Lymphangiogenesis


  1. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Skobe, M., Hawighorst, T., Jackson, D.G., Prevo, R., Janes, L., Velasco, P., Riccardi, L., Alitalo, K., Claffey, K., Detmar, M. Nat. Med. (2001) [Pubmed]
  2. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Mäkinen, T., Jussila, L., Veikkola, T., Karpanen, T., Kettunen, M.I., Pulkkanen, K.J., Kauppinen, R., Jackson, D.G., Kubo, H., Nishikawa, S., Ylä-Herttuala, S., Alitalo, K. Nat. Med. (2001) [Pubmed]
  3. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. Hirakawa, S., Kodama, S., Kunstfeld, R., Kajiya, K., Brown, L.F., Detmar, M. J. Exp. Med. (2005) [Pubmed]
  4. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. Byzova, T.V., Goldman, C.K., Jankau, J., Chen, J., Cabrera, G., Achen, M.G., Stacker, S.A., Carnevale, K.A., Siemionow, M., Deitcher, S.R., DiCorleto, P.E. Blood (2002) [Pubmed]
  5. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Karkkainen, M.J., Haiko, P., Sainio, K., Partanen, J., Taipale, J., Petrova, T.V., Jeltsch, M., Jackson, D.G., Talikka, M., Rauvala, H., Betsholtz, C., Alitalo, K. Nat. Immunol. (2004) [Pubmed]
  6. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. Cursiefen, C., Chen, L., Borges, L.P., Jackson, D., Cao, J., Radziejewski, C., D'Amore, P.A., Dana, M.R., Wiegand, S.J., Streilein, J.W. J. Clin. Invest. (2004) [Pubmed]
  7. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. He, Y., Kozaki, K., Karpanen, T., Koshikawa, K., Yla-Herttuala, S., Takahashi, T., Alitalo, K. J. Natl. Cancer Inst. (2002) [Pubmed]
  8. Hepatocyte growth factor promotes lymphatic vessel formation and function. Kajiya, K., Hirakawa, S., Ma, B., Drinnenberg, I., Detmar, M. EMBO J. (2005) [Pubmed]
  9. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Cho, C.H., Sung, H.K., Kim, K.T., Cheon, H.G., Oh, G.T., Hong, H.J., Yoo, O.J., Koh, G.Y. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Baldwin, M.E., Halford, M.M., Roufail, S., Williams, R.A., Hibbs, M.L., Grail, D., Kubo, H., Stacker, S.A., Achen, M.G. Mol. Cell. Biol. (2005) [Pubmed]
  11. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Su, J.L., Shih, J.Y., Yen, M.L., Jeng, Y.M., Chang, C.C., Hsieh, C.Y., Wei, L.H., Yang, P.C., Kuo, M.L. Cancer Res. (2004) [Pubmed]
  12. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Shibuya, M., Claesson-Welsh, L. Exp. Cell Res. (2006) [Pubmed]
  13. Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Cursiefen, C., Cao, J., Chen, L., Liu, Y., Maruyama, K., Jackson, D., Kruse, F.E., Wiegand, S.J., Dana, M.R., Streilein, J.W. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  14. Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels. Religa, P., Cao, R., Bjorndahl, M., Zhou, Z., Zhu, Z., Cao, Y. Blood (2005) [Pubmed]
  15. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. Vlahakis, N.E., Young, B.A., Atakilit, A., Sheppard, D. J. Biol. Chem. (2005) [Pubmed]
  16. Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Tille, J.C., Wang, X., Lipson, K.E., McMahon, G., Ferrara, N., Zhu, Z., Hicklin, D.J., Sleeman, J.P., Eriksson, U., Alitalo, K., Pepper, M.S. Exp. Cell Res. (2003) [Pubmed]
  17. Basic fibroblast growth factor-mediated lymphangiogenesis of lymphatic endothelial cells isolated from dog thoracic ducts: effects of heparin. Tan, Y. Jpn. J. Physiol. (1998) [Pubmed]
  18. Influence of angiostatin and thalidomide on lymphangiogenesis. Shao, X.J., Chi, X.Y. Lymphology. (2005) [Pubmed]
  19. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. Nagy, J.A., Vasile, E., Feng, D., Sundberg, C., Brown, L.F., Detmar, M.J., Lawitts, J.A., Benjamin, L., Tan, X., Manseau, E.J., Dvorak, A.M., Dvorak, H.F. J. Exp. Med. (2002) [Pubmed]
  20. Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia. Lymboussaki, A., Olofsson, B., Eriksson, U., Alitalo, K. Circ. Res. (1999) [Pubmed]
  21. Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3. Matsumura, K., Hirashima, M., Ogawa, M., Kubo, H., Hisatsune, H., Kondo, N., Nishikawa, S., Chiba, T., Nishikawa, S. Blood (2003) [Pubmed]
  22. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Karpanen, T., Egeblad, M., Karkkainen, M.J., Kubo, H., Ylä-Herttuala, S., Jäättelä, M., Alitalo, K. Cancer Res. (2001) [Pubmed]
  23. Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma. Skobe, M., Brown, L.F., Tognazzi, K., Ganju, R.K., Dezube, B.J., Alitalo, K., Detmar, M. J. Invest. Dermatol. (1999) [Pubmed]
  24. Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA. Weich, H.A., Bando, H., Brokelmann, M., Baumann, P., Toi, M., Barleon, B., Alitalo, K., Sipos, B., Sleeman, J. J. Immunol. Methods (2004) [Pubmed]
  25. Control of vascular cell differentiation by homeobox transcription factors. Gorski, D.H., Walsh, K. Trends Cardiovasc. Med. (2003) [Pubmed]
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