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MeSH Review

Transplantation, Isogeneic

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Disease relevance of Transplantation, Isogeneic


High impact information on Transplantation, Isogeneic

  • OB was observed in WT tracheal allografts at 3 weeks (53 +/- 2% luminal occlusion vs. 17 +/- 1% for isografts, P < 0.05) with sites of obstructive lesion formation coinciding with areas of CD3(+) CD8(+) T cell-rich lymphocytic bronchitis [6].
  • Allografts collected at 28 d were found to have significant increases in both inducible NO synthase (iNOS) mRNA and protein as well as in intimal thickness when compared with isografts [7].
  • Liver injury, activation of survival signals, and hepatic microcirculation were compared in nontreated and interleukin-6 (IL-6)-treated steatotic isografts [8].
  • Isograft lactase activities in both experimental transplant models were significantly higher than host intestinal lactase up to 28 days of age, suggesting that luminal factors are important in modulating lactase activity during the first 4 wk of postnatal life [9].
  • Jejunal isografts from each transgenic pedigree studied contained a lower percentage of hGH positive enteroendocrine cells than in the comparably aged intact jejunum.(ABSTRACT TRUNCATED AT 400 WORDS)[10]

Chemical compound and disease context of Transplantation, Isogeneic


Biological context of Transplantation, Isogeneic


Anatomical context of Transplantation, Isogeneic

  • The isograft not only developed into a morphologically normal intestine but also expressed differentiation antigens required for normal lymphoid homing to gut without exposure to luminal contents or lymphocytes [21].
  • Reperfusion after transplantation induces significant sinusoidal endothelial cell necrapoptosis in steatotic Zucker rat liver isografts, which is prevented by in vitro IL-6 pretreatment [8].
  • Immunocytochemical analysis of isografts harvested 4-6 wk after implantation revealed that activation of the intact endogenous mouse L-FABP gene (fabpl) in differentiating enterocytes is perfectly recapitulated as these cells are translocated along the crypt-to-villus axis [10].
  • Stimulation of lobulo-alveolar development in the mammary gland grafts by inclusion of a pituitary isograft under the renal capsule as a source of prolactin resulted in normal alveolar development in both Egfr-/- and wild-type transplants [22].
  • Long-term isografts of cultured fetal mouse pancreatic islets. The oncogenic effects of streptozotocin and the prevention of diabetic renal complications [23].

Associations of Transplantation, Isogeneic with chemical compounds

  • Three kinds of heterotopic transplants were performed for a total of 90: (1) Lewis rats received Lewis rat isografts, (2) Lewis rats received Brown Norway rat allografts, and (3) Lewis rats received cyclosporin A-treated allografts (15 mg/kg/day) [24].
  • Protein synthesis rates (nmol lysine/LV/hr) and total LV RNA and LV 18S RNA content were significantly greater in the balloon-loaded hearts when compared with the unloaded isografts and returned to levels similar to those measured in the in situ hearts [25].
  • Markedly enlarged pituitary isografts in mice contain high concentrations of estrogen receptors and low concentrations, if any, of progestin receptor [26].
  • Pregnancy-dependent TPDMT-4 mammary tumors, characterized by requiring estrogen, progesterone, and pituitary hormones for growth, grew continuously in female DDD mice carrying pituitary isografts [27].
  • TPDMT-4 mammary tumors, characterized by growth during pregnancy and regression after delivery, show continued growth in female DDD mice carrying pituitary isografts ectopically or a s.c. 17 beta-estradiol-plus-progesterone pellet [28].

Gene context of Transplantation, Isogeneic

  • This suggests that high concentrations of TNF-alpha can stimulate endothelial VCAM-1 expression, but these concentrations are apparently not achieved in cardiac isografts [29].
  • We report that the expression of VCAM-1 on isograft endothelia that was induced with anti-CD3 MAb was blocked by simultaneous treatment with either pentoxifylline, soluble tumor necrosis factor (TNF) receptor (TNFR-Fc), anti-IL4 MAb, or soluble IL4R, but not by anti-IFN-gamma MAb [29].
  • Transforming growth factor-beta, TNF-alpha, endothelin-1, and insulin-like growth factor-1 expression were increased 1.5-fold to 5.0-fold (p < or = 0.04 for each) in the allografts compared with the isografts at Weeks 2 through 6 [30].
  • The isografts expressed more epidermal growth factor than allografts (p < 0.001) [30].
  • MCP-1/JE production and macrophage infiltration was greater in allografts than isografts [31].

Analytical, diagnostic and therapeutic context of Transplantation, Isogeneic


  1. Effects of methanol extraction residue and therapeutic irradiation against established isografts and simulated local recurrence of mammary carcinomas. Yron, I., Cohen, D., Robinson, E., Haber, M., Weiss, D.W. Cancer Res. (1975) [Pubmed]
  2. Accelerated rejection of Fas ligand-expressing heart grafts. Takeuchi, T., Ueki, T., Nishimatsu, H., Kajiwara, T., Ishida, T., Jishage, K., Ueda, O., Suzuki, H., Li, B., Moriyama, N., Kitamura, T. J. Immunol. (1999) [Pubmed]
  3. Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Nakano, M., Yasunami, Y., Maki, T., Kodama, S., Ikehara, Y., Nakamura, T., Tanaka, M., Ikeda, S. Transplantation (2000) [Pubmed]
  4. Rejection of spontaneously accepted rat liver allografts with recipientinterleukin-2 treatment or donor irradiation. Tu, Y., Arima, T., Flye, M.W. Transplantation (1997) [Pubmed]
  5. Post-transplant hypertension in the rat: effects of captopril and native nephrectomy. Coffman, T.M., Himmelstein, S., Best, C., Klotman, P.E. Kidney Int. (1989) [Pubmed]
  6. Recipient iNOS but not eNOS deficiency reduces luminal narrowing in tracheal allografts. Minamoto, K., Pinsky, D.J. J. Exp. Med. (2002) [Pubmed]
  7. Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis. Shears, L.L., Kawaharada, N., Tzeng, E., Billiar, T.R., Watkins, S.C., Kovesdi, I., Lizonova, A., Pham, S.M. J. Clin. Invest. (1997) [Pubmed]
  8. In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Sun, Z., Klein, A.S., Radaeva, S., Hong, F., El-Assal, O., Pan, H.N., Jaruga, B., Batkai, S., Hoshino, S., Tian, Z., Kunos, G., Diehl, A.M., Gao, B. Gastroenterology (2003) [Pubmed]
  9. Ontogenic timing mechanism initiates the expression of rat intestinal sucrase activity. Yeh, K.Y., Holt, P.R. Gastroenterology (1986) [Pubmed]
  10. Epithelial cell differentiation in normal and transgenic mouse intestinal isografts. Rubin, D.C., Roth, K.A., Birkenmeier, E.H., Gordon, J.I. J. Cell Biol. (1991) [Pubmed]
  11. Graft protective effects of heme oxygenase 1 in mouse tracheal transplant-related obliterative bronchiolitis. Visner, G.A., Lu, F., Zhou, H., Latham, C., Agarwal, A., Zander, D.S. Transplantation (2003) [Pubmed]
  12. Successful treatment of diabetes in NOD mice with advanced disease by islet isografts following immunoregulation with Linomide (quinoline-3-carboxamide). Slavin, S., Weiss, L., Xia, W., Gross, D.J. Cell transplantation. (1996) [Pubmed]
  13. Hypertrophy of vascularized bone isograft in rats treated with cyclosporine A. Tsubone, T., Shigetomi, M., Ihara, K., Ikeda, K., Merida, L., Ohno, T., Sugiyama, T., Kawai, S. Calcif. Tissue Int. (2003) [Pubmed]
  14. Structure and function of orthotopic small bowel allografts in rats treated with cyclosporine. Lee, K.K., Schraut, W.H. Am. J. Surg. (1986) [Pubmed]
  15. Influence of sex steroids and prolactin on haloperidol-induced catalepsy. Nicoletti, F., Ferrara, N., Patti, F., Viglianesi, M., Rampello, L., Bianchi, A., Reggio, A., Scapagnini, U. Brain Res. (1983) [Pubmed]
  16. Inhibited growth in vivo of a mouse pregnancy-dependent mammary tumor (TPDMT-4) by an antiestrogen, 2alpha, 3alpha-epithio-5alpha-androstan-17beta-ol (10275-S). Matsuzawa, A., Yamamoto, T. Cancer Res. (1976) [Pubmed]
  17. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Furukawa, Y., Libby, P., Stinn, J.L., Becker, G., Mitchell, R.N. Am. J. Pathol. (2002) [Pubmed]
  18. Vascular smooth muscle alpha-actin expression as an indicator of parenchymal cell reprogramming in cardiac allografts. Subramanian, S.V., Orosz, C.G., Strauch, A.R. Transplantation (1998) [Pubmed]
  19. Alloantigen-dependent endothelial phenotype and lymphokine mRNA expression in rejecting murine cardiac allografts. Morgan, C.J., Pelletier, R.P., Hernandez, C.J., Teske, D.L., Huang, E., Ohye, R., Orosz, C.G., Ferguson, R.M. Transplantation (1993) [Pubmed]
  20. Expression of cell adhesion molecules from the L2/HNK-1 family in cerebellar isografts in mice. Poltorak, M., Freed, W.J., Schachner, M. Brain Res. (1989) [Pubmed]
  21. Murine isograft studies of gut immunity: recirculation and homing of mononuclear cells. Okuyama, S., Rubin, D., Streeter, P.R., Peters, M. Gastroenterology (1997) [Pubmed]
  22. Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Wiesen, J.F., Young, P., Werb, Z., Cunha, G.R. Development (1999) [Pubmed]
  23. Long-term isografts of cultured fetal mouse pancreatic islets. The oncogenic effects of streptozotocin and the prevention of diabetic renal complications. Mandel, T.E., Hoffman, L., Carter, W.M. Am. J. Pathol. (1981) [Pubmed]
  24. Early detection of cardiac allograft rejection with proton nuclear magnetic resonance. Sasaguri, S., LaRaia, P.J., Fabri, B.M., Fallon, J.T., Ayelsworth, C.A., D'Ambra, M.N., Newell, J.B., Brady, T.J., Buckley, M.J. Circulation (1985) [Pubmed]
  25. Isovolumic loading prevents atrophy of the heterotopically transplanted rat heart. Klein, I., Hong, C., Schreiber, S.S. Circ. Res. (1991) [Pubmed]
  26. High estrogen and low progestin receptor levels in outgrowths of hypophyseal isografts. Sluyser, M., Boot, L.M., Röpcke, G. Cancer Res. (1978) [Pubmed]
  27. Antitumor effect of two oral steroids, mepitiostane and fluoxymesterone, on a pregnancy-dependent mouse mammary tumor (TPDMT-4). Matsuzawa, A., Yamamoto, T. Cancer Res. (1977) [Pubmed]
  28. Antitumor effect of the antiestrogen, tamoxifen, ona pregnancy-dependent mouse mammary tumor (TPDMT-4). Matsuzawa, A., Mizuno, Y., Yamamoto, T. Cancer Res. (1981) [Pubmed]
  29. Regulation of endothelial VCAM-1 expression in murine cardiac grafts. Roles for TNF and IL4. Bergese, S., Pelletier, R., Vallera, D., Widmer, M., Orosz, C. Am. J. Pathol. (1995) [Pubmed]
  30. Growth factor upregulation during obliterative bronchiolitis in the mouse model. Aris, R.M., Walsh, S., Chalermskulrat, W., Hathwar, V., Neuringer, I.P. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  31. Early and late chemokine production correlates with cellular recruitment in cardiac allograft vasculopathy. Yun, J.J., Fischbein, M.P., Laks, H., Fishbein, M.C., Espejo, M.L., Ebrahimi, K., Irie, Y., Berliner, J., Ardehali, A. Transplantation (2000) [Pubmed]
  32. Effects of islet isografts on hemodynamic and vascular filtration changes in diabetic rats. Pugliese, G., Tilton, R.G., Chang, K., Speedy, A., Province, M., Eades, D.M., Lacy, P.E., Kilo, C., Williamson, J.R. Diabetes (1990) [Pubmed]
  33. Syngeneic transplantation of cryopreserved fetal mouse proislets. Hegre, O.D., Simeonovic, C.J., Lafferty, K.J. Diabetes (1984) [Pubmed]
  34. Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts. Li, X., Faustman, D. Transplantation (1993) [Pubmed]
  35. Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts. Fairchild, R.L., VanBuskirk, A.M., Kondo, T., Wakely, M.E., Orosz, C.G. Transplantation (1997) [Pubmed]
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