The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Endothelium, Lymphatic

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Endothelium, Lymphatic


High impact information on Endothelium, Lymphatic


Biological context of Endothelium, Lymphatic


Anatomical context of Endothelium, Lymphatic


Associations of Endothelium, Lymphatic with chemical compounds


Gene context of Endothelium, Lymphatic

  • No ligand has been identified for Flt4, whose expression becomes restricted during development to the lymphatic endothelium [23].
  • Recently, monoclonal antibodies against the human vascular endothelial growth factor receptor VEGFR-3 were shown to provide a specific antigenic marker for lymphatic endothelium in various normal tissues [24].
  • Background: Lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) is a selective marker for lymphatic endothelium and a homolog of CD44, the hyaluronan (HA) receptor [25].
  • Human D6 is a non-signaling seven-transmembrane receptor expressed on lymphatic endothelium interacting with most inflammatory CC-chemokines resulting in their rapid internalization [26].
  • Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family, comprising at least five cytokines specifically involved in the regulation of vascular and/or lymphatic endothelium differentiation [27].

Analytical, diagnostic and therapeutic context of Endothelium, Lymphatic


  1. Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter. Sugaya, M., Watanabe, T., Yang, A., Starost, M.F., Kobayashi, H., Atkins, A.M., Borris, D.L., Hanan, E.A., Schimel, D., Bryant, M.A., Roberts, N., Skobe, M., Staskus, K.A., Kaldis, P., Blauvelt, A. Blood (2005) [Pubmed]
  2. Mannose receptor (MR) and common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 direct the binding of cancer cells to the lymph vessel endothelium. Irjala, H., Alanen, K., Grénman, R., Heikkilä, P., Joensuu, H., Jalkanen, S. Cancer Res. (2003) [Pubmed]
  3. Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. Kyzas, P.A., Geleff, S., Batistatou, A., Agnantis, N.J., Stefanou, D. J. Pathol. (2005) [Pubmed]
  4. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. Timoshenko, A.V., Chakraborty, C., Wagner, G.F., Lala, P.K. Br. J. Cancer (2006) [Pubmed]
  5. Lymphatic metastasis and nm23H1 genetic instability in Chinese colon cancer patients. Su, Z.H., Li, J.C. World J. Gastroenterol. (2004) [Pubmed]
  6. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Stacker, S.A., Caesar, C., Baldwin, M.E., Thornton, G.E., Williams, R.A., Prevo, R., Jackson, D.G., Nishikawa, S., Kubo, H., Achen, M.G. Nat. Med. (2001) [Pubmed]
  7. Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium. Irjala, H., Johansson, E.L., Grenman, R., Alanen, K., Salmi, M., Jalkanen, S. J. Exp. Med. (2001) [Pubmed]
  8. Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells. Liu, Z.Y., Ganju, R.K., Wang, J.F., Ona, M.A., Hatch, W.C., Zheng, T., Avraham, S., Gill, P., Groopman, J.E. J. Clin. Invest. (1997) [Pubmed]
  9. Hepatocyte growth factor promotes lymphatic vessel formation and function. Kajiya, K., Hirakawa, S., Ma, B., Drinnenberg, I., Detmar, M. EMBO J. (2005) [Pubmed]
  10. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. Schacht, V., Ramirez, M.I., Hong, Y.K., Hirakawa, S., Feng, D., Harvey, N., Williams, M., Dvorak, A.M., Dvorak, H.F., Oliver, G., Detmar, M. EMBO J. (2003) [Pubmed]
  11. Visualization of lymphatic vessels through NF-kappaB activity. Saban, M.R., Mémet, S., Jackson, D.G., Ash, J., Roig, A.A., Israël, A., Saban, R. Blood (2004) [Pubmed]
  12. Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Hirakawa, S., Hong, Y.K., Harvey, N., Schacht, V., Matsuda, K., Libermann, T., Detmar, M. Am. J. Pathol. (2003) [Pubmed]
  13. CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Salmi, M., Koskinen, K., Henttinen, T., Elima, K., Jalkanen, S. Blood (2004) [Pubmed]
  14. Adhesion, transendothelial migration, and reverse transmigration of in vitro cultured dendritic cells. D'Amico, G., Bianchi, G., Bernasconi, S., Bersani, L., Piemonti, L., Sozzani, S., Mantovani, A., Allavena, P. Blood (1998) [Pubmed]
  15. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Schacht, V., Dadras, S.S., Johnson, L.A., Jackson, D.G., Hong, Y.K., Detmar, M. Am. J. Pathol. (2005) [Pubmed]
  16. A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis. Burman, A., Haworth, O., Hardie, D.L., Amft, E.N., Siewert, C., Jackson, D.G., Salmon, M., Buckley, C.D. J. Immunol. (2005) [Pubmed]
  17. Prognostic value of lymphatic and blood vessel invasion in neuroendocrine tumors of the lung. Schmid, K., Birner, P., Gravenhorst, V., End, A., Geleff, S. Am. J. Surg. Pathol. (2005) [Pubmed]
  18. Histogenesis of Kaposi's sarcoma and angiosarcoma of the face and the scalp. Holden, C.A. J. Invest. Dermatol. (1989) [Pubmed]
  19. Control of oxidative stress in microcirculation of spontaneously hypertensive rats. DeLano, F.A., Balete, R., Schmid-Schönbein, G.W. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  20. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Kahn, H.J., Bailey, D., Marks, A. Mod. Pathol. (2002) [Pubmed]
  21. Distribution of cell surface charges on mesothelium and lymphatic endothelium. Leak, L.V. Microvasc. Res. (1986) [Pubmed]
  22. Demonstration of the intralobular lymphatics in the guinea pig pancreas by an enzyme-histochemical method. Ji, R.C., Kato, S. J. Anat. (1997) [Pubmed]
  23. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. Lee, J., Gray, A., Yuan, J., Luoh, S.M., Avraham, H., Wood, W.I. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  24. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Valtola, R., Salven, P., Heikkilä, P., Taipale, J., Joensuu, H., Rehn, M., Pihlajaniemi, T., Weich, H., deWaal, R., Alitalo, K. Am. J. Pathol. (1999) [Pubmed]
  25. Expression of Lymphatic Vascular Endothelial Hyaluronan Receptor-1 (LYVE-1) in the Human Placenta. Gu, B., Alexander, J.S., Gu, Y., Zhang, Y., Lewis, D.F., Wang, Y. Lymphatic research and biology. (2006) [Pubmed]
  26. beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. Galliera, E., Jala, V.R., Trent, J.O., Bonecchi, R., Signorelli, P., Lefkowitz, R.J., Mantovani, A., Locati, M., Haribabu, B. J. Biol. Chem. (2004) [Pubmed]
  27. Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability. Odorisio, T., Schietroma, C., Zaccaria, M.L., Cianfarani, F., Tiveron, C., Tatangelo, L., Failla, C.M., Zambruno, G. J. Cell. Sci. (2002) [Pubmed]
  28. Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors. Rubbia-Brandt, L., Terris, B., Giostra, E., Dousset, B., Morel, P., Pepper, M.S. Clin. Cancer Res. (2004) [Pubmed]
  29. Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer. Birner, P., Schindl, M., Obermair, A., Breitenecker, G., Kowalski, H., Oberhuber, G. Int. J. Cancer (2001) [Pubmed]
  30. Thrombomodulin as a marker of vascular and lymphatic tumours. Appleton, M.A., Attanoos, R.L., Jasani, B. Histopathology (1996) [Pubmed]
  31. Prostaglandin I2 synthase in the lymphatic endothelium of rat liver as revealed by preembedding immunoelectron microscopy. Ito, Y., Magari, S., Sakanaka, M. Lymphology. (1989) [Pubmed]
WikiGenes - Universities