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Chemical Compound Review

aspartic acid     2-aminobutanedioic acid

Synonyms: H-DL-Asp-OH, PubChem8074, PubChem12370, AGN-PC-006I4D, NSC-3973, ...
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Disease relevance of L-aspartate


Psychiatry related information on L-aspartate


High impact information on L-aspartate


Chemical compound and disease context of L-aspartate


Biological context of L-aspartate


Anatomical context of L-aspartate


Associations of L-aspartate with other chemical compounds


Gene context of L-aspartate


Analytical, diagnostic and therapeutic context of L-aspartate

  • Initial rates of Na(+)-dependent L-glutamic and D-aspartic acid uptake were determined at various substrate concentrations using a fast sampling, rapid filtration apparatus, and the resulting data were analyzed by nonlinear computer fitting to various transport models [34].
  • Continuous on-line derivatization and selective separation of D-aspartic acid by a capillary electrophoresis system with a continuous sample introduction interface [35].
  • External reflection FTIR studies revealed very weak bands attributable to DL-aspartic acid in surface regions devoid of visible crystals, in agreement with the neutron reflectivity studies [26].
  • Specific interaction was detected between tRNA and its cognate L-amino acid by circular dichroism (CD) and fluorescence spectroscopy; fluorescence spectral change with saturation was observed when tRNAAsp was titrated only with L-aspartic acid, but not with D-aspartic acid, L- and D-glutamic acids [36].
  • Morphine and D-aspartic acid, when combined at their nonanalgesic doses, led to significant analgesia [37].


  1. Aslfm, the D-Aspartate Ligase Responsible for the Addition of D-Aspartic Acid onto the Peptidoglycan Precursor of Enterococcus faecium. Bellais, S., Arthur, M., Dubost, L., Hugonnet, J.E., Gutmann, L., van Heijenoort, J., Legrand, R., Brouard, J.P., Rice, L., Mainardi, J.L. J. Biol. Chem. (2006) [Pubmed]
  2. Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase. Aghaiypour, K., Wlodawer, A., Lubkowski, J. Biochemistry (2001) [Pubmed]
  3. Aggravation by morphine and D-aspartic acid of pyelonephritis induced by i.v. inoculation of Staphylococcus aureus in rats. Koyuncuoğlu, H., Güngör, M., Anğ, O., Inanç, D., Anğ-Küçüker, M., Sağduyu, H., Uysal, V. Infection (1988) [Pubmed]
  4. Structure of the O-polysaccharide of Proteus mirabilis O38 containing 2-acetamidoethyl phosphate and N-linked D-aspartic acid. Kondakova, A.N., Senchenkova, S.N., Gremyakov, A.I., Shashkov, A.S., Knirel, Y.A., Fudala, R., Kaca, W. Carbohydr. Res. (2003) [Pubmed]
  5. Stimulation of growth of Mycobacterium lepraemurium in cell-free liquid medium by DL-aspartic acid. Nakamura, M. Int. J. Lepr. Other Mycobact. Dis. (1982) [Pubmed]
  6. Intensification and attenuation of morphine dependence by D-aspartic acid and PLG. Koyuncuoğlu, H., Güngör, M., Sağduyu, H., Aricioğlu, F. Pharmacol. Biochem. Behav. (1990) [Pubmed]
  7. Free D-aspartate and D-alanine in normal and Alzheimer brain. Fisher, G.H., D'Aniello, A., Vetere, A., Padula, L., Cusano, G.P., Man, E.H. Brain Res. Bull. (1991) [Pubmed]
  8. Synergistic anti-human immunodeficiency virus type 1 effect of hydroxamate compounds with 2',3'-dideoxyinosine in infected resting human lymphocytes. Malley, S.D., Grange, J.M., Hamedi-Sangsari, F., Vila, J.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100 degrees C. Boehm, M.F., Bada, J.L. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  10. Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins. McFadden, P.N., Clarke, S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  11. d-Aspartic acid: An endogenous amino acid with an important neuroendocrine role. D'Aniello, A. Brain Res. Brain Res. Rev. (2007) [Pubmed]
  12. Heterotropic effects of dipolar amino acids on the activity of the anionic amino acid transport system X-AG in rabbit jejunal brush-border membrane vesicles. Maenz, D.D., Chenu, C., Berteloot, A. J. Biol. Chem. (1993) [Pubmed]
  13. Antagonistic effect of L-aspartic acid on decrease in body weight, and food and fluid intake, and naloxone reversible rectal temperature depression caused by D-aspartic acid. Koyuncuoglu, H., Berkman, K., Wildmann, J., Matthaei, H. Polish journal of pharmacology and pharmacy. (1982) [Pubmed]
  14. Antimycotic activity of some amino acids against dermatophytes. Pandey, D.K., Chandra, H., Tripathi, N.N., Dixit, S.N. Arzneimittel-Forschung. (1984) [Pubmed]
  15. Evaluation of D-amino acid levels in rat by gas chromatography-selected ion monitoring mass spectrometry: no evidence for subacute toxicity of orally fed D-proline and D-aspartic acid. Schieber, A., Brückner, H., Rupp-Classen, M., Specht, W., Nowitzki-Grimm, S., Classen, H.G. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  16. Age-dependent accumulation of protein residues which can be hydrolyzed to D-aspartic acid in human erythrocytes. Brunauer, L.S., Clarke, S. J. Biol. Chem. (1986) [Pubmed]
  17. Substrate translocation kinetics of excitatory amino acid carrier 1 probed with laser-pulse photolysis of a new photolabile precursor of D-aspartic acid. Grewer, C., Madani Mobarekeh, S.A., Watzke, N., Rauen, T., Schaper, K. Biochemistry (2001) [Pubmed]
  18. Purification, characterization, and localization of aspartoacylase from bovine brain. Kaul, R., Casanova, J., Johnson, A.B., Tang, P., Matalon, R. J. Neurochem. (1991) [Pubmed]
  19. Secretion of D-aspartic acid by the rat testis and its role in endocrinology of the testis and spermatogenesis. D'Aniello, A., Di Fiore, M.M., D'Aniello, G., Colin, F.E., Lewis, G., Setchell, B.P. FEBS Lett. (1998) [Pubmed]
  20. Age-related changes in the D-aspartic acid content of the teeth of the senescence-accelerated mouse. Ohtani, S., Yamamoto, T., Sugimoto, H., Sashima, M., Satoh, M. Arch. Oral Biol. (2000) [Pubmed]
  21. ATP release, adenosine formation, and modulation of dynorphin and glutamic acid release by adenosine analogues in rat hippocampal mossy fiber synaptosomes. Terrian, D.M., Hernandez, P.G., Rea, M.A., Peters, R.I. J. Neurochem. (1989) [Pubmed]
  22. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. Hosoya, K., Sugawara, M., Asaba, H., Terasaki, T. J. Neurochem. (1999) [Pubmed]
  23. A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice. Errico, F., Pirro, M.T., Affuso, A., Spinelli, P., De Felice, M., D'Aniello, A., Di Lauro, R. Gene (2006) [Pubmed]
  24. Racemization of aspartic acid in the extracellular matrix proteins of primary and secondary dentin. Saleh, N., Deutsch, D., Gil-Av, E. Calcif. Tissue Int. (1993) [Pubmed]
  25. Confirmation of D-aspartic acid in the novel dipeptide beta-aspartylglycine isolated from tissue extract of Aplysia kurodai. Sato, M., Yamaguchi, T., Kanno, N., Sato, Y. Biochem. J. (1989) [Pubmed]
  26. Neutron reflectivity and external reflection FTIR studies of DL-aspartic acid crystallization beneath nylon 6 spread films. Jamieson, M.J., Cooper, S.J., Miller, A.F., Holt, S.A. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  27. d-Aspartic acid and nitric oxide as regulators of androgen production in boar testis. Lamanna, C., Assisi, L., Vittoria, A., Botte, V., Di Fiore, M.M. Theriogenology (2007) [Pubmed]
  28. Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. D'Aniello, A., Di Cosmo, A., Di Cristo, C., Annunziato, L., Petrucelli, L., Fisher, G. Life Sci. (1996) [Pubmed]
  29. D-aspartic acid in purified myelin and myelin basic protein. Fisher, G.H., Garcia, N.M., Payan, I.L., Cadilla-Perezrios, R., Sheremata, W.A., Man, E.H. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  30. Protein carboxyl methyltransferase from cow eye lens. McFadden, P.N., Horwitz, J., Clarke, S. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  31. Endogenous testicular D-aspartic acid regulates gonadal aromatase activity in boar. Lamanna, C., Assisi, L., Botte, V., Di Fiore, M.M. J. Endocrinol. Invest. (2006) [Pubmed]
  32. Alteration in the D-amino acid content of the rat pineal gland under anesthesia. Hamase, K., Homma, H., Takigawa, Y., Imai, K. Amino Acids (1999) [Pubmed]
  33. Vasopressin release by D-aspartic acid, morphine and prolyl-leucyl-glycinamide (PLG) in DI Brattleboro rats. Koyuncuoğlu, H., Berkman, K., Hatipoğlu, I., Sabuncu, H. Pharmacol. Biochem. Behav. (1984) [Pubmed]
  34. pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles. Maenz, D.D., Chenu, C., Breton, S., Berteloot, A. J. Biol. Chem. (1992) [Pubmed]
  35. Continuous on-line derivatization and selective separation of D-aspartic acid by a capillary electrophoresis system with a continuous sample introduction interface. Fan, L., Cheng, Y., Chen, H., Liu, L., Chen, X., Hu, Z. Electrophoresis (2004) [Pubmed]
  36. Specific interaction between tRNA and its cognate amino acid as detected by circular dichroism and fluorescence spectroscopy. Watanabe, K., Miura, K. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  37. Antinociceptive effect of D-aspartic acid in mice. Onat, F., Toker, F., Aslan, N., Oktay, S., Berkman, K. Pharmacol. Biochem. Behav. (1995) [Pubmed]
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