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Chemical Compound Review

Propanedial     propanedial

Synonyms: MALONALDEHYDE, CHEMBL446036, CCRIS 5168, NCI-C54842, AG-F-87888, ...
 
 
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Disease relevance of malonaldehyde

 

Psychiatry related information on malonaldehyde

 

High impact information on malonaldehyde

  • Macrophages possess a receptor that binds low-density lipoproteins (LDL) containing lysine residues modified by acetylation (Ac LDL), acetoacetylation (AcAc LDL) or malondialdehyde treatment [11].
  • One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde [12].
  • The results are consistent with the cross-linking of bacterial DNA by malonaldehyde leading to mutagenesis expressed through the error-prone repair system [2].
  • The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC [13].
  • Those EO- autoantibodies that bound to oxidized phospholipids (e.g., EO6) inhibited the binding and degradation of CuOx-LDL by mouse peritoneal macrophages up to 91%, whereas other IgM EO- autoantibodies, selected for binding to malondialdehyde (MDA)-LDL, had no influence on binding of either CuOx-LDL or MDA-LDL by macrophages [14].
 

Chemical compound and disease context of malonaldehyde

 

Biological context of malonaldehyde

 

Anatomical context of malonaldehyde

 

Associations of malonaldehyde with other chemical compounds

 

Gene context of malonaldehyde

  • Extensively oxidized LDL and LDL modified by exposure to fatty acid peroxidation products were efficient competitors for the uptake of labeled oxidized LDL by SR-AI/II-deficient Kupffer cells, while acetyl LDL and malondialdehyde-modified LDL were relatively poor competitors [34].
  • However, no significant decrease in superoxide dismutase activity or significant increase in malondialdehyde levels was observed in iron dextran-treated rats [35].
  • Levels of malondialdehyde, a marker of ROS generation and oxidant stress, were elevated in UCP2(- /-) livers at every examined time point [36].
  • Plasma extracellular glutathione peroxidase enzymatic activity was also decreased, whereas the lipid peroxidation products malondialdehyde and 4-hydroxy-2(E)-nonenal were increased in kidneys and blood plasma of cystic mice [37].
  • Genetic ablation of iNOS gene conferred to mice a significant resistance to TNBS induced lethality and colonic damage, and notably reduced nitrotyrosine formation and concentrations of malondialdehyde; it did not, however, affect neutrophil infiltration and intestinal ICAM-1 expression in the injured tissue [38].
 

Analytical, diagnostic and therapeutic context of malonaldehyde

References

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  21. Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis. Zingarelli, B., Szabó, C., Salzman, A.L. Gastroenterology (1999) [Pubmed]
  22. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Hagen, T.M., Liu, J., Lykkesfeldt, J., Wehr, C.M., Ingersoll, R.T., Vinarsky, V., Bartholomew, J.C., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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  25. Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment. Schwarzer, E., Turrini, F., Ulliers, D., Giribaldi, G., Ginsburg, H., Arese, P. J. Exp. Med. (1992) [Pubmed]
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  28. Iron chelation as a possible mechanism for aspirin-induced malondialdehyde production by mouse liver microsomes and mitochondria. Schwarz, K.B., Arey, B.J., Tolman, K., Mahanty, S. J. Clin. Invest. (1988) [Pubmed]
  29. Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. Neale, T.J., Ojha, P.P., Exner, M., Poczewski, H., Rüger, B., Witztum, J.L., Davis, P., Kerjaschki, D. J. Clin. Invest. (1994) [Pubmed]
  30. Effects of verapamil on the acute toxicity of doxorubicin in vivo. Sridhar, R., Dwivedi, C., Anderson, J., Baker, P.B., Sharma, H.M., Desai, P., Engineer, F.N. J. Natl. Cancer Inst. (1992) [Pubmed]
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  32. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. Houglum, K., Filip, M., Witztum, J.L., Chojkier, M. J. Clin. Invest. (1990) [Pubmed]
  33. Enhancement of platelet function by superoxide anion. Handin, R.I., Karabin, R., Boxer, G.J. J. Clin. Invest. (1977) [Pubmed]
  34. Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene. Ling, W., Lougheed, M., Suzuki, H., Buchan, A., Kodama, T., Steinbrecher, U.P. J. Clin. Invest. (1997) [Pubmed]
  35. Effects of iron loading on free radical scavenging enzymes and lipid peroxidation in rat liver. Fletcher, L.M., Roberts, F.D., Irving, M.G., Powell, L.W., Halliday, J.W. Gastroenterology (1989) [Pubmed]
  36. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Horimoto, M., Fülöp, P., Derdák, Z., Wands, J.R., Baffy, G. Hepatology (2004) [Pubmed]
  37. Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease. Maser, R.L., Vassmer, D., Magenheimer, B.S., Calvet, J.P. J. Am. Soc. Nephrol. (2002) [Pubmed]
  38. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Zingarelli, B., Szabó, C., Salzman, A.L. Gut (1999) [Pubmed]
  39. Oxygen radicals generated at reflow induce peroxidation of membrane lipids in reperfused hearts. Ambrosio, G., Flaherty, J.T., Duilio, C., Tritto, I., Santoro, G., Elia, P.P., Condorelli, M., Chiariello, M. J. Clin. Invest. (1991) [Pubmed]
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