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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Gastric bypass for treating severe obesity.

Gastric bypass (RY- GBP) has a very small gastric pouch with a 1-cm diameter Roux-Y gastrojejunostomy. RY- GBP is associated with early satiety and an aversion to sweets secondary to dumping syndrome symptoms and has a significantly better weight loss than various gastroplasty procedures, including the vertical banded gastroplasty. However, it may be associated with vitamin B-12 deficiency and iron deficiency anemia in menstruating females, preventable with prophylactic oral iron and vitamin B-12. With an 80% 5 y follow-up, RY- GBP patients lose two-thirds of their excess weight within 2 y, 60% at 5 y, and greater than 50% at 9 y. The RY- GBP can be beaten by nibbling "junk foods" (potato or corn chips). Conversion to a malabsorptive procedure may cause severe malnutrition and fat-soluble vitamin deficiencies and should be used only for "superobese" patients who fail a standard RY- GBP and have severe comorbidity. RY- GBP is the most effective procedure for morbid obesity, especially in patients addicted to "sweets."[1]


  1. Gastric bypass for treating severe obesity. Sugerman, H.J., Kellum, J.M., Engle, K.M., Wolfe, L., Starkey, J.V., Birkenhauer, R., Fletcher, P., Sawyer, M.J. Am. J. Clin. Nutr. (1992) [Pubmed]
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