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MeSH Review

Obesity, Morbid

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Disease relevance of Obesity, Morbid


Psychiatry related information on Obesity, Morbid

  • Sixteen patients who underwent gastric stapling procedure for morbid obesity were assessed pre- and post-operatively on several psychosocial dimensions using a number of self-report questionnaires including the Eating Disorders Inventory, Locus of Control, and Millon's Clinical Multi-Axial Inventory [6].

High impact information on Obesity, Morbid


Chemical compound and disease context of Obesity, Morbid


Biological context of Obesity, Morbid


Anatomical context of Obesity, Morbid


Gene context of Obesity, Morbid

  • Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity [27].
  • In summary, our results do not support a major role of the human OBR gene in the development of morbid obesity in our population [28].
  • Genetically obese rodents with mutations of leptin or the leptin receptor are defective in leptin signaling and develop morbid obesity and diabetes [29].
  • A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity [30].
  • Lepr(db-dmpg) had a deletion in the extracellular domain of LEPR: Lepr(db-rlpy) exhibited a large DNA deletion, leading to a complete lack of LEPR: All three mutations led to morbid obesity and diabetes [31].

Analytical, diagnostic and therapeutic context of Obesity, Morbid


  1. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. Clément, K., Vaisse, C., Manning, B.S., Basdevant, A., Guy-Grand, B., Ruiz, J., Silver, K.D., Shuldiner, A.R., Froguel, P., Strosberg, A.D. N. Engl. J. Med. (1995) [Pubmed]
  2. Hepatic free fatty acids in alcoholic liver disease and morbid obesity. Mavrelis, P.G., Ammon, H.V., Gleysteen, J.J., Komorowski, R.A., Charaf, U.K. Hepatology (1983) [Pubmed]
  3. Hepatic effects of jejunoileal bypass for morbid obesity. Holzbach, R.T. Am. J. Clin. Nutr. (1977) [Pubmed]
  4. Alteration of the leptin network in late morbid obesity induced in mice by brain infection with canine distemper virus. Bernard, A., Cohen, R., Khuth, S.T., Vedrine, B., Verlaeten, O., Akaoka, H., Giraudon, P., Belin, M.F. J. Virol. (1999) [Pubmed]
  5. Growth hormone-binding protein directly depends on serum leptin levels in adults with different nutritional status. Llopis, M.A., Granada, M.L., Cuatrecasas, G., Formiguera, X., Sánchez-Planell, L., Sanmartí, A., Alastrué, A., Rull, M., Corominas, A., Foz, M. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  6. A prospective study of psychosocial aspects of gastric stapling surgery. Chandarana, P.C., Conlon, P., Holliday, R.L., Deslippe, T., Field, V.A. Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Université d'Ottawa. (1990) [Pubmed]
  7. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., Froguel, P. J. Clin. Invest. (2000) [Pubmed]
  8. Leptin receptor gene variation and obesity: lack of association in a white British male population. Gotoda, T., Manning, B.S., Goldstone, A.P., Imrie, H., Evans, A.L., Strosberg, A.D., McKeigue, P.M., Scott, J., Aitman, T.J. Hum. Mol. Genet. (1997) [Pubmed]
  9. Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Ma, L., Tataranni, P.A., Hanson, R.L., Infante, A.M., Kobes, S., Bogardus, C., Baier, L.J. Diabetes (2005) [Pubmed]
  10. SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. Duan, C., Li, M., Rui, L. J. Biol. Chem. (2004) [Pubmed]
  11. SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Eberlé, D., Clément, K., Meyre, D., Sahbatou, M., Vaxillaire, M., Le Gall, A., Ferré, P., Basdevant, A., Froguel, P., Foufelle, F. Diabetes (2004) [Pubmed]
  12. Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity? Mingrone, G., Manco, M., Calvani, M., Castagneto, M., Naon, D., Zorzano, A. Diabetologia (2005) [Pubmed]
  13. Gallstone formation prophylaxis after gastric restrictive procedures for weight loss: a randomized double-blind placebo-controlled trial. Miller, K., Hell, E., Lang, B., Lengauer, E. Ann. Surg. (2003) [Pubmed]
  14. The effect of rapid weight loss due to jejunoileal bypass on total cholesterol and high-density lipoprotein. Dobrea, G.M., Wieland, R.G., Johnson, M.W. Am. J. Clin. Nutr. (1981) [Pubmed]
  15. Vitamin A deficiency in a newborn resulting from maternal hypovitaminosis A after biliopancreatic diversion for the treatment of morbid obesity. Huerta, S., Rogers, L.M., Li, Z., Heber, D., Liu, C., Livingston, E.H. Am. J. Clin. Nutr. (2002) [Pubmed]
  16. Endogenous ethanol production and hepatic disease following jejunoileal bypass for morbid obesity. Mezey, E., Imbembo, A.L., Potter, J.J., Rent, K.C., Lombardo, R., Holt, P.R. Am. J. Clin. Nutr. (1975) [Pubmed]
  17. A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q. Clément, K., Dina, C., Basdevant, A., Chastang, N., Pelloux, V., Lahlou, N., Berlan, M., Langin, D., Guy-Grand, B., Froguel, P. Diabetes (1999) [Pubmed]
  18. Peroxisome proliferator-activated receptor gamma gene locus is related to body mass index and lipid values in healthy nonobese subjects. Knoblauch, H., Busjahn, A., Müller-Myhsok, B., Faulhaber, H.D., Schuster, H., Uhlmann, R., Luft, F.C. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  19. Change in vascular adhesion protein-1 and metabolic phenotypes after vertical banded gastroplasty for morbid obesity. Li, H.Y., Lee, W.J., Chen, M.J., Chuang, L.M. Obes. Res. (2005) [Pubmed]
  20. Body composition and source of weight loss after bariatric surgery. Gahtan, V., Goode, S.E., Kurto, H.Z., Schocken, D.D., Powers, P., Rosemurgy, A.S. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (1997) [Pubmed]
  21. Changes in leptin, plasminogen activator factor and oxidative stress in morbidly obese patients following open and laparoscopic Swedish adjustable gastric banding. Uzun, H., Zengin, K., Taskin, M., Aydin, S., Simsek, G., Dariyerli, N. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2004) [Pubmed]
  22. Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity. Alessi, M.C., Bastelica, D., Morange, P., Berthet, B., Leduc, I., Verdier, M., Geel, O., Juhan-Vague, I. Diabetes (2000) [Pubmed]
  23. Gastric acid secretion and vitamin B12 absorption after vertical Roux-en-Y gastric bypass for morbid obesity. Smith, C.D., Herkes, S.B., Behrns, K.E., Fairbanks, V.F., Kelly, K.A., Sarr, M.G. Ann. Surg. (1993) [Pubmed]
  24. Ammonium acid urate calculi: a reevaluation of risk factors. Soble, J.J., Hamilton, B.D., Streem, S.B. J. Urol. (1999) [Pubmed]
  25. Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity. Chacón, M.R., Richart, C., Gómez, J.M., Megía, A., Vilarrasa, N., Fernández-Real, J.M., García-España, A., Miranda, M., Masdevall, C., Ricard, W., Caubet, E., Soler, J., Vendrell, J. Cytokine (2006) [Pubmed]
  26. Gastric acid and serum gastrin secretion before and after bypass of the small intestine for morbid obesity. Coutsoftides, T., Baranowski, J., Himal, H.S. Surgery, gynecology & obstetrics. (1976) [Pubmed]
  27. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Vasseur, F., Helbecque, N., Lobbens, S., Vasseur-Delannoy, V., Dina, C., Clément, K., Boutin, P., Kadowaki, T., Scherer, P.E., Froguel, P. Diabetologia (2005) [Pubmed]
  28. Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families. Francke, S., Clement, K., Dina, C., Inoue, H., Behn, P., Vatin, V., Basdevant, A., Guy-Grand, B., Permutt, M.A., Froguel, P., Hager, J. Hum. Genet. (1997) [Pubmed]
  29. Modulation of circulating leptin levels by its soluble receptor. Huang, L., Wang, Z., Li, C. J. Biol. Chem. (2001) [Pubmed]
  30. A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. Mergen, M., Mergen, H., Ozata, M., Oner, R., Oner, C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  31. New leptin receptor mutations in mice: Lepr(db-rtnd), Lepr(db-dmpg) and Lepr(db-rlpy). Kim, J.H., Taylor, P.N., Young, D., Karst, S.Y., Nishina, P.M., Naggert, J.K. J. Nutr. (2003) [Pubmed]
  32. Is mediastinitis a preventable complication? A 10-year review. Baskett, R.J., MacDougall, C.E., Ross, D.B. Ann. Thorac. Surg. (1999) [Pubmed]
  33. Sex hormone levels and intestinal absorption of estradiol and D-norgestrel in women following bypass surgery for morbid obesity. Andersen, A.N., Lebech, P.E., Sørensen, T.I., Borggaard, B. International journal of obesity. (1982) [Pubmed]
  34. Postoperative chest percussion with postural drainage in obese patients following gastric stapling. Torrington, K.G., Sorenson, D.E., Sherwood, L.M. Chest (1984) [Pubmed]
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