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MeSH Review

Obesity, Morbid

 
 
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Disease relevance of Obesity, Morbid

 

Psychiatry related information on Obesity, Morbid

  • Sixteen patients who underwent gastric stapling procedure for morbid obesity were assessed pre- and post-operatively on several psychosocial dimensions using a number of self-report questionnaires including the Eating Disorders Inventory, Locus of Control, and Millon's Clinical Multi-Axial Inventory [6].
 

High impact information on Obesity, Morbid

 

Chemical compound and disease context of Obesity, Morbid

 

Biological context of Obesity, Morbid

 

Anatomical context of Obesity, Morbid

 

Gene context of Obesity, Morbid

  • Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity [27].
  • In summary, our results do not support a major role of the human OBR gene in the development of morbid obesity in our population [28].
  • Genetically obese rodents with mutations of leptin or the leptin receptor are defective in leptin signaling and develop morbid obesity and diabetes [29].
  • A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity [30].
  • Lepr(db-dmpg) had a deletion in the extracellular domain of LEPR: Lepr(db-rlpy) exhibited a large DNA deletion, leading to a complete lack of LEPR: All three mutations led to morbid obesity and diabetes [31].
 

Analytical, diagnostic and therapeutic context of Obesity, Morbid

References

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  18. Peroxisome proliferator-activated receptor gamma gene locus is related to body mass index and lipid values in healthy nonobese subjects. Knoblauch, H., Busjahn, A., Müller-Myhsok, B., Faulhaber, H.D., Schuster, H., Uhlmann, R., Luft, F.C. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  19. Change in vascular adhesion protein-1 and metabolic phenotypes after vertical banded gastroplasty for morbid obesity. Li, H.Y., Lee, W.J., Chen, M.J., Chuang, L.M. Obes. Res. (2005) [Pubmed]
  20. Body composition and source of weight loss after bariatric surgery. Gahtan, V., Goode, S.E., Kurto, H.Z., Schocken, D.D., Powers, P., Rosemurgy, A.S. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (1997) [Pubmed]
  21. Changes in leptin, plasminogen activator factor and oxidative stress in morbidly obese patients following open and laparoscopic Swedish adjustable gastric banding. Uzun, H., Zengin, K., Taskin, M., Aydin, S., Simsek, G., Dariyerli, N. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2004) [Pubmed]
  22. Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity. Alessi, M.C., Bastelica, D., Morange, P., Berthet, B., Leduc, I., Verdier, M., Geel, O., Juhan-Vague, I. Diabetes (2000) [Pubmed]
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  24. Ammonium acid urate calculi: a reevaluation of risk factors. Soble, J.J., Hamilton, B.D., Streem, S.B. J. Urol. (1999) [Pubmed]
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  27. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Vasseur, F., Helbecque, N., Lobbens, S., Vasseur-Delannoy, V., Dina, C., Clément, K., Boutin, P., Kadowaki, T., Scherer, P.E., Froguel, P. Diabetologia (2005) [Pubmed]
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  30. A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. Mergen, M., Mergen, H., Ozata, M., Oner, R., Oner, C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  31. New leptin receptor mutations in mice: Lepr(db-rtnd), Lepr(db-dmpg) and Lepr(db-rlpy). Kim, J.H., Taylor, P.N., Young, D., Karst, S.Y., Nishina, P.M., Naggert, J.K. J. Nutr. (2003) [Pubmed]
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  34. Postoperative chest percussion with postural drainage in obese patients following gastric stapling. Torrington, K.G., Sorenson, D.E., Sherwood, L.M. Chest (1984) [Pubmed]
 
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