Disease relevance of Vitamin B 12 Deficiency

• In mild megaloblastic anemia, secondary either to folic acid of vitamin B12 deficiency, and in severe iron deficiency anemia, the erythrocyte membrane protein pattern was normal [1].
• Vitamin B12 deficiency and multiple sclerosis [2].
• Optic neuropathy in vitamin B12 deficiency [3].
• Three patients with autoimmune hemolytic anemia had macrocytosis (MCV greater than 110 fl) without folate or vitamin B12 deficiency [4].
• Other major late effects included posttransfusion viral hepatitis, eight patients; CNS toxicity, two patients; endocrine impairment, 14 patients; vitamin B12 deficiency, two patients; esophageal stricture, one patient; urinary tract problems, two patients; and musculoskeletal defects, three patients [5].

Psychiatry related information on Vitamin B 12 Deficiency

• There were no cases of dementia due to normal-pressure hydrocephalus, subdural hematoma, hypothyroidism, vitamin B12 deficiency, or neurosyphilis [6].
• Catatonia and other psychiatric symptoms with vitamin B12 deficiency [7].
• OBJECTIVE: The main hypothesis was that subtle vitamin B12 deficiencies occur more commonly in senile dementia of Alzheimer type (SDAT) that in healthy elderly individuals, and may be revealed by elevated total serum homocysteine (tHcy) [8].
• Complications of vitamin B12 deficiency are myriad, ranging from lethargy and weight loss to dementia [9].
• Peripheral neuropathy was the most common condition associated with vitamin B12 deficiency and affective disorder with folate deficiency [10].

High impact information on Vitamin B 12 Deficiency

• Shaky-leg syndrome and vitamin B12 deficiency [11].
• Oral or parenteral therapy for vitamin B12 deficiency [12].
• Optic neuropathy in vitamin B12 deficiency [13].
• During the recovery period from the effects of nitrous oxide the pattern of correction of the dU-suppression test changed from that of vitamin-B12 deficiency to folate deficiency [14].
• The abnormality revealed by the dU suppression tests was identical with that found in vitamin-B12 deficiency, but the patients' serum-B12 concentrations were normal [15].

Chemical compound and disease context of Vitamin B 12 Deficiency

• Folate supplementation and the risk of masking vitamin B12 deficiency [16].
• Urinary methylmalonic acid to detect vitamin B12 deficiency [17].
• Benefits are expected through the improvement of folate and homocysteine status, but there is also a risk of masking or precipitating clinical manifestations related to vitamin B12 deficiency with increasing exposure to folic acid [18].
• Letter: Ascorbic acid and vitamin B12 deficiency [19].
• Oral or parenteral therapy for vitamin B12 deficiency [20].

Biological context of Vitamin B 12 Deficiency

• Images in clinical medicine. Vitamin B12 deficiency [21].
• The neurology of vitamin B12 deficiency. Metabolic mechanisms [22].
• To elucidate the biochemical basis of megaloblastic hematopoiesis, the cellular content and metabolism of deoxyribonucleoside triphosphates (dNTPs) were investigated using the bone marrow cells from nine patients with untreated vitamin B12 deficiency and one with folic acid deficiency [23].
• Altered homeostasis of CoA has been observed in diverse disease states including starvation, diabetes, alcoholism, Reye syndrome (RS), medium-chain acyl CoA dehydrogenase deficiency, vitamin B12 deficiency, and certain tumors [24].
• Iron and folate deficiency each suppressed Hb A2 levels in beta-thalassemia heterozygotes; however, vitamin B12 deficiency did not alter the percentage of Hb A2 in thalassemia [25].

Anatomical context of Vitamin B 12 Deficiency

• Mean reticulocyte size was disproportionately larger than normal in patients presenting with folate or vitamin B12 deficiency [26].
• Indoles were measured in cerebrospinal fluid (CSF) from control patients, from patients suffering from folate deficiency, and from patients with vitamin B12 deficiency [27].
• The authors describe two patients with organic psychosis who had vitamin B12 deficiency and no hematologic or spinal cord abnormalities [28].
• Since the terminal ileum exclusively absorbs vitamin B12, removal of ileum from the gastrointestinal trace for use in lower urinary tract reconstruction may predispose patients to vitamin B12 deficiency [29].
• Because vitamin B-12 deficiency perturbs folate metabolism, we determined the effects of nitrous oxide inactivation of methionine synthase on the compartmentation of folate metabolism in rat pancreas [30].

Gene context of Vitamin B 12 Deficiency

• This protein was rarely detected in normal serum but appeared when normal subjects were treated with recombinant erythropoietin and disappeared after full treatment of patients with megaloblastic anemia due to vitamin B12 deficiency [31].
• CONCLUSION: MTHFR 677 TT individuals are more liable to hyperhomocysteinemia under vitamin B12 deficiency than the other two genotypes [32].
• Hepatic citrate synthase activity has been shown to be increased 2- to 3-fold in vitamin B12 deficiency [33].
• Multiple sclerosis associated with vitamin B12 deficiency [34].
• Coma and axonal degeneration in vitamin B12 deficiency [35].

Analytical, diagnostic and therapeutic context of Vitamin B 12 Deficiency

• MEASUREMENTS: Serum levels of vitamin B12, folate, methylmalonic acid, and total homocysteine measured before and after treatment in participants with vitamin B12 deficiency [36].
• OBJECTIVE: To examine the development of chemical and clinical vitamin B12 deficiency after total gastrectomy, and to evaluate the efficacy of supplemental oral B12 administration [37].
• PATIENTS AND METHODS: We performed a prospective cohort study involving 138 patients who had anemia and vitamin B12 deficiency [38].
• Any patient who had a low vitamin B12 serum level (less than 200 pg./ml.) underwent a Schilling test to confirm malabsorptive vitamin B12 deficiency [29].
• PURPOSE: We assessed the risk of tissue cobalamin (vitamin B12) deficiency in patients after various types of urinary diversion [39].

References