Disease relevance of Gastric Bypass

• Seven morbidly obese (body mass index = 45.8 +/- 2.5, mean +/- SE) patients, including four with non-insulin-dependent diabetes mellitus (NIDDM), underwent gastric bypass surgery for treatment of their obesity [1].
• Vitamin B12 deficiency after gastric bypass surgery for obesity [2].
• SUMMARY BACKGROUND DATA: Gastric bypass can be performed safely and provides acceptable weight loss, but concerns remain about possible long-term complications such as vitamin B12 malabsorption [3].
• CONCLUSIONS: After vertical Roux-en-Y gastric bypass for morbid obesity, acid secretion is virtually absent and food-bound vitamin B12 is maldigested and subsequently malabsorbed [3].
• The gastric bypass favorably affected non-insulin-dependent diabetes (NIDDM), hypertension, physical and role functioning, and several measures of mental health [4].

Psychiatry related information on Gastric Bypass

• This case presents a patient with thiamine deficiency after gastric bypass, although unusual in itself, further complicating the case was the initial diagnosis of acute psychosis that was scheduled for electroconvulsive therapy [5].

High impact information on Gastric Bypass

• Both free [Ca2+] and total calcium [Ca] increased 40% from mean values of 1.12 and 5.05 mmol/L at gastric bypass to 1.86 and 8.60 mmol/L after gallstone formation (P less than 0.05) [6].
• We studied 25 morbidly obese patients-12 with type 2 diabetes, 5 with impaired glucose tolerance, and 8 with normal glucose tolerance (NGT)-before and after a biliopancreatic diversion (BPD) with Roux-en-Y gastric bypass (RYGBP) [7].
• The present studies were designed to determine rates of EGP and the activities of G6Pase and GK in obese patients scheduled for gastric bypass surgery [8].
• RESULTS: Compared with lean and obese controls, patients following Roux-en-Y gastric bypass (RYGB) had increased postprandial plasma PYY and GLP-1 favoring enhanced satiety [9].
• METHODS: Basal and pentagastrin-stimulated peak acid outputs from the proximal gastric pouch were measured in ten patients after vertical Roux-en-Y gastric bypass using a perfused orogastric tube technique [3].

Chemical compound and disease context of Gastric Bypass

• Mild elevation of fasting plasma glucose is a strong risk factor for postoperative complications in gastric bypass patients [10].
• These data provide biochemical support for the clinical association of obesity and cholesterol gallstone formation and are evidence against the possibility that gastric bypass is a lithogenic operation [11].
• Accordingly, a double-blind prospective trial of prophylactic cefazolin was carried out in 53 consecutive patients who underwent gastric bypass surgery for morbid obesity [12].
• Excellent weight result after Roux-en-Y gastric bypass in spite of gastro-gastric fistula [13].
• BACKGROUND: Portal vein thrombosis is rare following Roux-en-Y gastric bypass (RYGBP) [14].

Biological context of Gastric Bypass

• Haloperidol pharmacokinetics following gastric bypass surgery [15].
• Vertical banded gastroplasty and gastric bypass operations may be dramatically effective in improving blood pressure, insulin sensitivity and glucose tolerance [16].
• The study was designed to examine the effect of erythromycin on small bowel motility in a placebo-controlled trial of post gastric bypass patients utilizing a standardized nuclear medicine test [17].
• Gastric emptying of two test meals, consisting of ground beef and water and ground beef with 25 percent dextrose was measured with a scintigraphic technique in patients after gastric bypass surgery and in control subjects [18].
• Insulin resistance, leptin and TNF-alpha system in morbidly obese women after gastric bypass [19].

Anatomical context of Gastric Bypass

• Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans [20].
• PATIENTS AND INTERVENTIONS: Complete blood cell count and serum levels of iron, total iron binding capacity, ferritin, vitamin B12, and folate were determined preoperatively and at 6-month intervals postoperatively in 56 menstruating women who had Roux-en-Y gastric bypass [21].
• Therefore, we believe that the mother's gastric bypass had caused a decrease in available intrinsic factor, resulting in subclinical vitamin B12 deficiency and decreased breast milk B12 [22].

Associations of Gastric Bypass with chemical compounds

• The Greenville gastric bypass. Progress report at 3 years [23].
• Utilization of intravenously administered D-methionine was measured by morbidly obese subjects fed parenterally after elective gastric bypass surgery [24].
• Before gastric bypass, serum albumin was low in 11% of cases, alkaline phosphatase was high in 14% of cases, AST was high in 11% of cases, and total bilirubin was high in 1% of cases [25].
• Salicylsalicylic acid (salsalate) is an effective antirheumatic drug that bypasses gastric absorption and also avoids cyclooxygenase inhibition [26].
• We conclude that oral MV prophylaxis is useful in preventing folate and B-12 deficiency after gastric bypass [27].

Gene context of Gastric Bypass

• CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects [28].
• We examined fasting plasma insulin, acylation-stimulating protein (ASP), leptin, adiponectin, ghrelin, and metabolic/cardiovascular risk profile before and 15 +/- 6 months after isolated Roux-en-Y gastric bypass surgery in 50 morbidly obese subjects [29].
• Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects [29].
• GIP, a gactor in the enteroinsulin axis, decreases and may play a role in the correction of DM-II after gastric bypass [30].
• Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass [31].

Analytical, diagnostic and therapeutic context of Gastric Bypass

• Gastroplasty (GP) or gastric bypass with exclusion of 90% of the distal stomach (GBP) have largely replaced small bowel bypass in the surgical management of morbid obesity [32].
• Amylin/insulin secretory ratios were determined in nine morbidly obese subjects consenting to portal venous catheterization at the time of gastric bypass surgery [33].
• In contrast to bariatric malabsorption techniques, like jejunoileal bypass and gastric bypass, cyclosporine pharmacokinetics do not appear to be influenced by gastric banding [34].
• The authors describe a morbidly obese patient in whom developed an unusual type of Richter hernia after a laparoscopic isolated Roux-en-Y gastric bypass at a 10-mm trocar site [35].
• Here we report our management of intractable postoperative reflux with a Belsey Mark IV fundoplication performed one year after a successful Roux-en-y gastric bypass operation [36].

References