Disease relevance of Dumping Syndrome

• METHODS: Ten patients were studied with chronic fat malabsorption, calcium oxalate stones, and hyperoxaluria thought to be caused by jejunoileal bypass (1) and Roux-en-Y gastric bypass surgery for obesity (4), dumping syndrome secondary to gastrectomy (2), celiac sprue (1), chronic pancreatitis (1), and ulcerative colitis in remission (1) [1].
• We recommend that all patients with dumping syndrome undergo glucose tolerance tests and plasma insulin determinations to ascertain whether they have reactive hypoglycemia [2].
• The results show that the hypovolemia in dumping syndrome is associated with a significant decrease in ANP activity [3].
• The use of Sandostatin in acute oesophageal variceal bleeding, pancreatic pseudocysts, gastrointestinal and pancreatic external fistulae, short bowel syndrome, dumping syndrome and AIDS-related refractory hypersecretory diarrhea has provided encouraging results [4].
• The realisation that serotonin plays a role not only in the carcinoid syndrome but also in migraine, nociception, dumping syndrome, vascular disease and hypertension, has led to an enormous amount of activity in search of serotonin antagonists [5].

High impact information on Dumping Syndrome

• The observation of greatly increased postprandial plasma GLP-1 7-36 levels in patients with postgastrectomy dumping syndrome suggests that it may mediate the hyperinsulinaemia and reactive hypoglycaemia of this disorder [6].
• Low dose acarbose without symptoms of malabsorption in the dumping syndrome [7].
• Twelve patients with the dumping syndrome took on one occasion oral hypertonic glucose and on another a similar glucose drink to which pectin was added [8].
• Neurotensin and the dumping syndrome [9].
• BAY g 5421, a glycoside-hydrolase inhibitor, produced symptomatic improvement in ten patients with the dumping syndrome [10].

Chemical compound and disease context of Dumping Syndrome

• The early dumping syndrome and propranolol [11].
• Efficacy of octreotide acetate in treatment of severe postgastrectomy dumping syndrome [12].
• In addition, erythromycin administration induced a significant plasma fall at 15 (p < 0.05) and 30 (p < 0.01) min and a significant increase in pulse rate at 15 and 30 min (p < 0.01) after consumption of the hypertonic glucose solution, whereas three subjects experienced symptoms suggesting dumping syndrome [13].
• Dumping syndrome and the regulation of peptide YY with verapamil [14].
• In order to study any relationship between postprandial norepinephrine, the enteroinsular axis, and plasma glucose, twelve patients with dumping syndrome and nine controls were studied [15].

Biological context of Dumping Syndrome

• Gastric emptying was significantly faster and the fall in plasma volume significantly greater in those patients who experienced symptoms after the ingestion of hypertonic glucose than in those who did not, clearly demonstrating that the dumping syndrome is associated with an increased rate of gastric emptying [16].

Gene context of Dumping Syndrome

• Significant release of neurotensin occurred in seven patients while three patients had release of VIP, further implicating these two peptides as part of the pathophysiologic spectrum of the "dumping syndrome."[17]
• Neurotensin, vasoactive intestinal peptide, and Roux-en-Y gastrojejunostomy. Their role in the dumping syndrome [17].
• The present study evaluates the acute and chronic use of a long-acting somatostatin analog, octreotide acetate, in the treatment of patients with severe postgastrectomy dumping syndrome [12].
• Plasma peptide YY (PYY) in dumping syndrome [18].
• Infant dumping syndrome after gastroesophageal reflux surgery [19].

Analytical, diagnostic and therapeutic context of Dumping Syndrome

• The effect of long acting somatostatin analogue, SMS 201-995, on postprandial dumping syndrome was studied in eight patients with Billroth II gastric resection [20].
• Acarbose attenuates hypoglycemia from dumping syndrome in an elderly man with gastrectomy [21].
• An oral glucose tolerance test confirmed the diagnosis of dumping syndrome [22].

References